sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 1.000 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.673 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.607 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.607 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.605 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.603 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.597 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.588 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.587 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.583 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.582 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.580 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.577 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.577 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.575 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.573 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.573 | |
| 1w76 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.571 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.571 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.570 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.569 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.566 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.565 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.564 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.563 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.562 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.560 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.552 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.547 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.547 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.544 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.543 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.540 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.538 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.537 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.537 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.536 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.534 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.520 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.519 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.517 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.505 | |
| 4a16 | H34 | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.479 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.476 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.468 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.465 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.462 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.462 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.461 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.459 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.455 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.454 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.454 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.454 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.450 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.450 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.449 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.448 | |
| 3frk | TQP | QdtB | / | 0.448 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.447 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.447 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.443 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.443 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.442 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.442 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.442 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.441 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3d64 | NAD | Adenosylhomocysteinase | / | 0.440 |