scPDB - Distribution of Binding site Similarity values of 4erf entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4erf	0R3	E3 ubiquitin-protein ligase Mdm2	6.3.2

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4erf	0R3	E3 ubiquitin-protein ligase Mdm2	6.3.2	1.000
4jvr	1MT	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.556
4dij	BLF	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.517
4jwr	1MY	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.516
1rv1	IMZ	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.504
2cle	F6F	Tryptophan synthase alpha chain	/	0.472
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.471
4g7g	VFV	Lanosterol 14-alpha-demethylase	/	0.470
2rkv	ZBA	Trichothecene 3-O-acetyltransferase	/	0.468
5eb5	FAD	(R)-mandelonitrile lyase 1	4.1.2.10	0.466
4fjy	FJY	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.465
3vso	EK1	Peroxisome proliferator-activated receptor gamma	/	0.464
3b9l	AZZ	Serum albumin	/	0.462
3sp9	IL2	Peroxisome proliferator-activated receptor delta	/	0.461
2znp	K55	Peroxisome proliferator-activated receptor delta	/	0.460
2hwr	DRD	Peroxisome proliferator-activated receptor gamma	/	0.458
3r37	4CO	4-hydroxybenzoyl-CoA thioesterase	3.1.2.23	0.458
3vt7	VDX	Vitamin D3 receptor	/	0.458
3v9v	21L	Peroxisome proliferator-activated receptor gamma	/	0.457
4cdm	FO1	Deoxyribodipyrimidine photolyase	/	0.457
4kla	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.456
4g3j	VNT	Lanosterol 14-alpha-demethylase	/	0.455
1noo	CAH	Camphor 5-monooxygenase	1.14.15.1	0.454
1lsj	NAD	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	1.1.1.35	0.453
2w8y	486	Progesterone receptor	/	0.453
3d8v	UD1	Bifunctional protein GlmU	/	0.453
1qnf	FAD	Deoxyribodipyrimidine photo-lyase	4.1.99.3	0.452
2wyv	NAD	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.452
4ere	0R2	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.452
4hnc	0UT	Mandelate racemase	/	0.452
4j03	FVS	Bifunctional epoxide hydrolase 2	3.1.3.76	0.452
4z26	FAD	Putative GMC-type oxidoreductase R135	1	0.452
1k6v	XN2	Gag-Pol polyprotein	3.4.23.16	0.451
3cge	NDP	Coenzyme A disulfide reductase	/	0.451
3hl0	NAD	Maleylacetate reductase	/	0.451
3lj3	WYE	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.451
4amb	DUD	Putative glycosyl transferase	/	0.451
3uoz	FAD	2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase	1.14.13.160	0.450
4a8v	2AN	Major pollen allergen Bet v 1-J	/	0.450
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.449
3c0i	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.449
4a9i	P9I	Bromodomain-containing protein 2	/	0.449
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.449
4jsc	1OY	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.449
5irn	ADP	Nucleotide binding oligomerization domain containing 2	/	0.449
1qbg	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.448
1t88	CAM	Camphor 5-monooxygenase	1.14.15.1	0.448
4e4q	RRH	Peroxisome proliferator-activated receptor gamma	/	0.448
1v59	FAD	Dihydrolipoyl dehydrogenase, mitochondrial	1.8.1.4	0.447
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.447
1dhi	MTX	Dihydrofolate reductase	1.5.1.3	0.446
1dz4	CAM	Camphor 5-monooxygenase	1.14.15.1	0.446
1k6t	XN1	Gag-Pol polyprotein	3.4.23.16	0.446
1ydt	IQB	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.446
1h66	FAD	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.445
2po7	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.445
3fwj	CAM	Camphor 5-monooxygenase	1.14.15.1	0.445
4u03	GTP	Cyclic GMP-AMP synthase	/	0.445
2d29	FAD	Acyl-CoA dehydrogenase	/	0.444
2hdh	NAD	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	1.1.1.35	0.444
2hrc	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.444
2vn0	TDZ	Cytochrome P450 2C8	/	0.444
3r34	COA	4-hydroxybenzoyl-CoA thioesterase	3.1.2.23	0.444
4kky	CAM	Camphor 5-monooxygenase	1.14.15.1	0.444
6cp4	CAM	Camphor 5-monooxygenase	1.14.15.1	0.444
1bim	0QB	Renin	3.4.23.15	0.443
1k7f	IAV	Tryptophan synthase alpha chain	/	0.443
1t4e	DIZ	E3 ubiquitin-protein ligase Mdm2	6.3.2	0.443
1t85	CAM	Camphor 5-monooxygenase	1.14.15.1	0.443
2qd4	CHD	Ferrochelatase, mitochondrial	4.99.1.1	0.443
2zax	CAM	Camphor 5-monooxygenase	1.14.15.1	0.443
3cgd	NAD	Coenzyme A disulfide reductase	/	0.443
3gwf	FAD	Cyclohexanone monooxygenase	/	0.443
3nr4	PYV	Abscisic acid receptor PYL2	/	0.443
1t87	CAM	Camphor 5-monooxygenase	1.14.15.1	0.442
1xdd	AAY	Integrin alpha-L	/	0.442
3c0g	3AM	Peripheral plasma membrane protein CASK	2.7.11.1	0.442
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.442
3u8h	BHP	Phospholipase A2, membrane associated	/	0.442
4gdy	0X1	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.442
1ek2	CDU	Bifunctional epoxide hydrolase 2	/	0.441
2q66	ATP	Poly(A) polymerase	2.7.7.19	0.441
3be9	P04	Casein kinase II subunit alpha	2.7.11.1	0.441
3il1	B5D	Glutamate receptor 2	/	0.441
3mdv	CL6	Cholesterol 24-hydroxylase	/	0.441
3oqf	S51	Renin	3.4.23.15	0.441
4cp4	CAM	Camphor 5-monooxygenase	1.14.15.1	0.441
1eio	GCH	Gastrotropin	/	0.440
3ozd	4CT	S-methyl-5'-thioadenosine phosphorylase	/	0.440
4ei7	GDP	Plasmid replication protein RepX	/	0.440