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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4emyPLPAminotransferase class I and II

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4emyPLPAminotransferase class I and II/1.000
4rkdKETAminotransferase/0.574
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.546
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.531
1x28PGUAspartate aminotransferase2.6.1.10.508
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.501
1arhPPDAspartate aminotransferase2.6.1.10.497
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.491
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.482
4w5kPLPAspartate aminotransferase, mitochondrial/0.482
3elePLPAminotransferase/0.477
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.463
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.463
1argPPDAspartate aminotransferase2.6.1.10.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.455
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.453
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.453
2ay5IOPAromatic-amino-acid aminotransferase2.6.1.570.449
1ex75GPGuanylate kinase2.7.4.80.445
2anb5GPGuanylate kinase2.7.4.80.445
3gf4UPGUDP-galactopyranose mutase5.4.99.90.445
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.443
1gtrATPGlutamine--tRNA ligase6.1.1.180.442
1s4oGDPGlycolipid 2-alpha-mannosyltransferase/0.441