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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4elh53IDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4elh53IDihydrofolate reductase/1.000
4elb34SDihydrofolate reductase/0.728
3fl8RARDihydrofolate reductase/0.623
4elf35IDihydrofolate reductase/0.617
4ele31IDihydrofolate reductase/0.599
4elb34RDihydrofolate reductase/0.592
4elg52JDihydrofolate reductase/0.555
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.527
2qk8MTXDihydrofolate reductase/0.526
1diuBDMDihydrofolate reductase1.5.1.30.522
1jolFFODihydrofolate reductase1.5.1.30.506
1disBDMDihydrofolate reductase1.5.1.30.497
3fl9TOPDihydrofolate reductase/0.477
3och2MXDihydrofolate reductase1.5.1.30.475
4cd2FOLDihydrofolate reductase1.5.1.30.472
1drbMTXDihydrofolate reductase1.5.1.30.471
1draMTXDihydrofolate reductase1.5.1.30.468
3syiFADSulfide-quinone reductase/0.467
4xe606UDihydrofolate reductase1.5.1.30.467
1tdrMTXDihydrofolate reductase1.5.1.30.465
2drcMTXDihydrofolate reductase1.5.1.30.462
3t2kFADSulfide-quinone reductase/0.461
4b7dQLECytochrome P450 monooxygenase PikC/0.461
1ddsMTXDihydrofolate reductase1.5.1.30.460
1rf7DHFDihydrofolate reductase1.5.1.30.460
1re7FOLDihydrofolate reductase1.5.1.30.455
4r21STRCytochrome P450 family 17 polypeptide 2/0.454
1rc4DDFDihydrofolate reductase1.5.1.30.453
4dfrMTXDihydrofolate reductase1.5.1.30.453
3eigMTXDihydrofolate reductase1.5.1.30.452
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
3q44D50M1 family aminopeptidase3.4.110.451
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.451
3t2zFADSulfide-quinone reductase/0.450
1rb3MTXDihydrofolate reductase1.5.1.30.448
1zhzERGOxysterol-binding protein homolog 4/0.447
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.447
3t14FADSulfide-quinone reductase/0.446
4ez8DHFThymidylate synthase2.1.1.450.445
4o701QKBromodomain-containing protein 4/0.445
1qmzATPCyclin-dependent kinase 22.7.11.220.444
3drcMTXDihydrofolate reductase1.5.1.30.444
4j6bPLOCytochrome P450 monooxygenase/0.443
2w9hTOPDihydrofolate reductase1.5.1.30.442
3sz0FADSulfide-quinone reductase/0.442
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
3l0lHC3Nuclear receptor ROR-gamma/0.441
3qwbNDPProbable quinone oxidoreductase1.6.5.50.441
3kpkFADSulfide-quinone reductase/0.440