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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4elg52JDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4elg52JDihydrofolate reductase/1.000
4ele31IDihydrofolate reductase/0.688
3fl8RARDihydrofolate reductase/0.641
4elb34SDihydrofolate reductase/0.580
4elf35IDihydrofolate reductase/0.577
4elb34RDihydrofolate reductase/0.566
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.565
2qk8MTXDihydrofolate reductase/0.533
4elh53IDihydrofolate reductase/0.530
3och2MXDihydrofolate reductase1.5.1.30.525
4dfrMTXDihydrofolate reductase1.5.1.30.520
1draMTXDihydrofolate reductase1.5.1.30.518
1jolFFODihydrofolate reductase1.5.1.30.517
1tdrMTXDihydrofolate reductase1.5.1.30.506
2drcMTXDihydrofolate reductase1.5.1.30.500
1ddsMTXDihydrofolate reductase1.5.1.30.497
1drbMTXDihydrofolate reductase1.5.1.30.497
1dhjMTXDihydrofolate reductase1.5.1.30.496
1diuBDMDihydrofolate reductase1.5.1.30.496
1ddrMTXDihydrofolate reductase1.5.1.30.487
1dyjDDFDihydrofolate reductase1.5.1.30.483
3drcMTXDihydrofolate reductase1.5.1.30.483
4xe606UDihydrofolate reductase1.5.1.30.482
4cd2FOLDihydrofolate reductase1.5.1.30.480
1rb3MTXDihydrofolate reductase1.5.1.30.478
1rf7DHFDihydrofolate reductase1.5.1.30.476
3eigMTXDihydrofolate reductase1.5.1.30.470
1rc4DDFDihydrofolate reductase1.5.1.30.467
1re7FOLDihydrofolate reductase1.5.1.30.467
1disBDMDihydrofolate reductase1.5.1.30.464
5hi6MTXDihydrofolate reductase/0.463
1uydPU8Heat shock protein HSP 90-alpha/0.453
2hm9TRRDihydrofolate reductase1.5.1.30.453
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.453
4r20AERCytochrome P450 family 17 polypeptide 2/0.453
3a1l2CCCytochrome P450/0.452
4r21STRCytochrome P450 family 17 polypeptide 2/0.452
3fl9TOPDihydrofolate reductase/0.450
3ia4MTXDihydrofolate reductase/0.448
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
2z3uCRRCytochrome P450/0.446
3inxJZCHeat shock protein HSP 90-alpha/0.444
3sa27DRDihydrofolate reductase/0.443
1pkfEPDEpothilone C/D epoxidase1.140.442
4fgg0U5Dihydrofolate reductase1.5.1.30.441
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.441
1zhzERGOxysterol-binding protein homolog 4/0.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440