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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ele31IDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ele31IDihydrofolate reductase/1.000
3fl8RARDihydrofolate reductase/0.730
4elf35IDihydrofolate reductase/0.692
4elg52JDihydrofolate reductase/0.648
4elb34SDihydrofolate reductase/0.598
4elb34RDihydrofolate reductase/0.568
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.543
4elh53IDihydrofolate reductase/0.538
2qk8MTXDihydrofolate reductase/0.523
1drbMTXDihydrofolate reductase1.5.1.30.508
3och2MXDihydrofolate reductase1.5.1.30.504
1jolFFODihydrofolate reductase1.5.1.30.499
1diuBDMDihydrofolate reductase1.5.1.30.495
1draMTXDihydrofolate reductase1.5.1.30.487
4dfrMTXDihydrofolate reductase1.5.1.30.485
1ddsMTXDihydrofolate reductase1.5.1.30.479
1dhjMTXDihydrofolate reductase1.5.1.30.478
1ddrMTXDihydrofolate reductase1.5.1.30.477
2drcMTXDihydrofolate reductase1.5.1.30.474
3fl9TOPDihydrofolate reductase/0.470
1rc4DDFDihydrofolate reductase1.5.1.30.465
1tdrMTXDihydrofolate reductase1.5.1.30.465
1rb3MTXDihydrofolate reductase1.5.1.30.462
1rf7DHFDihydrofolate reductase1.5.1.30.460
3drcMTXDihydrofolate reductase1.5.1.30.458
1disBDMDihydrofolate reductase1.5.1.30.454
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
1re7FOLDihydrofolate reductase1.5.1.30.450
4j6bPLOCytochrome P450 monooxygenase/0.442
4xe606UDihydrofolate reductase1.5.1.30.441