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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4elb34SDihydrofolate reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4elb34SDihydrofolate reductase/1.000
4elh53IDihydrofolate reductase/0.720
4ele31IDihydrofolate reductase/0.639
3fl8RARDihydrofolate reductase/0.637
4elb34RDihydrofolate reductase/0.592
4elg52JDihydrofolate reductase/0.589
4elf35IDihydrofolate reductase/0.587
2qk8MTXDihydrofolate reductase/0.549
1jolFFODihydrofolate reductase1.5.1.30.538
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.538
1diuBDMDihydrofolate reductase1.5.1.30.536
1drbMTXDihydrofolate reductase1.5.1.30.533
1draMTXDihydrofolate reductase1.5.1.30.531
1disBDMDihydrofolate reductase1.5.1.30.530
4dfrMTXDihydrofolate reductase1.5.1.30.524
2drcMTXDihydrofolate reductase1.5.1.30.523
3och2MXDihydrofolate reductase1.5.1.30.518
1rf7DHFDihydrofolate reductase1.5.1.30.513
1tdrMTXDihydrofolate reductase1.5.1.30.513
1ddsMTXDihydrofolate reductase1.5.1.30.511
1ddrMTXDihydrofolate reductase1.5.1.30.508
1rb3MTXDihydrofolate reductase1.5.1.30.504
1dyjDDFDihydrofolate reductase1.5.1.30.503
4cd2FOLDihydrofolate reductase1.5.1.30.503
1rc4DDFDihydrofolate reductase1.5.1.30.502
1dhjMTXDihydrofolate reductase1.5.1.30.499
3drcMTXDihydrofolate reductase1.5.1.30.498
3eigMTXDihydrofolate reductase1.5.1.30.497
4xe606UDihydrofolate reductase1.5.1.30.491
1re7FOLDihydrofolate reductase1.5.1.30.487
3fl9TOPDihydrofolate reductase/0.480
4qi9MTXDihydrofolate reductase/0.477
5hi6MTXDihydrofolate reductase/0.477
2hm9TRRDihydrofolate reductase1.5.1.30.469
4r20AERCytochrome P450 family 17 polypeptide 2/0.463
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
4x5jFOLDihydrofolate reductase1.5.1.30.462
3q44D50M1 family aminopeptidase3.4.110.459
1cd2FOLDihydrofolate reductase1.5.1.30.456
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.453
1dhfFOLDihydrofolate reductase1.5.1.30.451
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.451
1drfFOLDihydrofolate reductase1.5.1.30.450
3t2zFADSulfide-quinone reductase/0.449
4x5iFOLDihydrofolate reductase1.5.1.30.449
4h9814QUncharacterized protein/0.448
1jomFFODihydrofolate reductase1.5.1.30.447
3p99LNPLanosterol 14-alpha-demethylase/0.443
1rg7MTXDihydrofolate reductase1.5.1.30.442
4ej1FOLDihydrofolate reductase1.5.1.30.442
2zzaFOLDihydrofolate reductase/0.441
2dhfDZFDihydrofolate reductase1.5.1.30.440