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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.11.000
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.495
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.455
4l9i8PRRhodopsin kinase/0.453
3a8wATPProtein kinase C iota type2.7.11.130.452
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.450
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.449
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441