Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ek816KCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ek816KCyclin-dependent kinase 22.7.11.221.000
3sw719KCyclin-dependent kinase 22.7.11.220.632
2w05FRTCyclin-dependent kinase 22.7.11.220.628
2r3iSCFCyclin-dependent kinase 22.7.11.220.621
4fks46KCyclin-dependent kinase 22.7.11.220.619
3sw418KCyclin-dependent kinase 22.7.11.220.603
2r3p3SCCyclin-dependent kinase 22.7.11.220.594
2c6iDT1Cyclin-dependent kinase 22.7.11.220.592
4acm7YGCyclin-dependent kinase 22.7.11.220.589
1oirHDYCyclin-dependent kinase 22.7.11.220.587
4fkq42KCyclin-dependent kinase 22.7.11.220.586
1oitHDTCyclin-dependent kinase 22.7.11.220.583
2xmyCDKCyclin-dependent kinase 22.7.11.220.577
1pxmCK5Cyclin-dependent kinase 22.7.11.220.575
2r3jSCJCyclin-dependent kinase 22.7.11.220.575
3rpv26ZCyclin-dependent kinase 22.7.11.220.575
3rni21ZCyclin-dependent kinase 22.7.11.220.574
2r64740Cyclin-dependent kinase 22.7.11.220.573
1y91CT9Cyclin-dependent kinase 22.7.11.220.572
2r3r6SCCyclin-dependent kinase 22.7.11.220.572
3lfqA28Cyclin-dependent kinase 22.7.11.220.572
2a0cCK9Cyclin-dependent kinase 22.7.11.220.571
3qtxX43Cyclin-dependent kinase 22.7.11.220.571
4fkv61KCyclin-dependent kinase 22.7.11.220.565
2c6o4SPCyclin-dependent kinase 22.7.11.220.564
3qqhX0ACyclin-dependent kinase 22.7.11.220.562
3rk909ZCyclin-dependent kinase 22.7.11.220.561
1pxkCK3Cyclin-dependent kinase 22.7.11.220.560
3lfnA27Cyclin-dependent kinase 22.7.11.220.560
3pj8404Cyclin-dependent kinase 22.7.11.220.560
3r1yX76Cyclin-dependent kinase 22.7.11.220.559
3sqq99ZCyclin-dependent kinase 22.7.11.220.559
3unk0BYCyclin-dependent kinase 22.7.11.220.559
1h1s4SPCyclin-dependent kinase 22.7.11.220.558
4fkr45KCyclin-dependent kinase 22.7.11.220.558
2w06FRVCyclin-dependent kinase 22.7.11.220.557
3qu0X40Cyclin-dependent kinase 22.7.11.220.556
3iggEFQCyclin-dependent kinase 22.7.11.220.554
3s2pPMUCyclin-dependent kinase 22.7.11.220.554
2uznC96Cyclin-dependent kinase 22.7.11.220.553
2r3o2SCCyclin-dependent kinase 22.7.11.220.552
2vv9IM9Cyclin-dependent kinase 22.7.11.220.552
2w1hL0FCyclin-dependent kinase 22.7.11.220.552
4bgh3I6Cyclin-dependent kinase 22.7.11.220.552
3qtzX42Cyclin-dependent kinase 22.7.11.220.551
1ykr628Cyclin-dependent kinase 22.7.11.220.549
3ezrEZRCyclin-dependent kinase 22.7.11.220.549
4fko20KCyclin-dependent kinase 22.7.11.220.549
2x1nX1NCyclin-dependent kinase 22.7.11.220.548
1ke6LS2Cyclin-dependent kinase 22.7.11.220.545
2a4lRRCCyclin-dependent kinase 22.7.11.220.545
1ke7LS3Cyclin-dependent kinase 22.7.11.220.544
1pxlCK4Cyclin-dependent kinase 22.7.11.220.544
2r3mSCXCyclin-dependent kinase 22.7.11.220.544
3r1sX73Cyclin-dependent kinase 22.7.11.220.544
2r3lSCWCyclin-dependent kinase 22.7.11.220.543
1gih1PUCyclin-dependent kinase 22.7.11.220.542
3le62BZCyclin-dependent kinase 22.7.11.220.540
3qxoX65Cyclin-dependent kinase 22.7.11.220.540
1w0xOLOCyclin-dependent kinase 22.7.11.220.538
2btrU73Cyclin-dependent kinase 22.7.11.220.537
3py0SU9Cyclin-dependent kinase 22.7.11.220.537
1e1xNW1Cyclin-dependent kinase 22.7.11.220.536
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.536
1pxpCK8Cyclin-dependent kinase 22.7.11.220.535
1urwI1PCyclin-dependent kinase 22.7.11.220.535
2r3q5SCCyclin-dependent kinase 22.7.11.220.535
3r9dX6BCyclin-dependent kinase 22.7.11.220.535
4fkt48KCyclin-dependent kinase 22.7.11.220.534
3ezvEZVCyclin-dependent kinase 22.7.11.220.533
3pxyJWSCyclin-dependent kinase 22.7.11.220.532
3r7yZ04Cyclin-dependent kinase 22.7.11.220.532
3r71X86Cyclin-dependent kinase 22.7.11.220.531
3rjc06ZCyclin-dependent kinase 22.7.11.220.530
3r8lZ30Cyclin-dependent kinase 22.7.11.220.529
3rm618ZCyclin-dependent kinase 22.7.11.220.529
1oguST8Cyclin-dependent kinase 22.7.11.220.528
2c6tDT5Cyclin-dependent kinase 22.7.11.220.528
4fkw62KCyclin-dependent kinase 22.7.11.220.528
1h0w207Cyclin-dependent kinase 22.7.11.220.527
1p2a5BNCyclin-dependent kinase 22.7.11.220.527
3r73X87Cyclin-dependent kinase 22.7.11.220.527
3rk708ZCyclin-dependent kinase 22.7.11.220.527
3rmf20ZCyclin-dependent kinase 22.7.11.220.527
2r3kSCQCyclin-dependent kinase 22.7.11.220.526
1h0vUN4Cyclin-dependent kinase 22.7.11.220.525
2uzoC62Cyclin-dependent kinase 22.7.11.220.525
4fkpLS5Cyclin-dependent kinase 22.7.11.220.525
2j9mPY8Cyclin-dependent kinase 22.7.11.220.524
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.523
3rm719ZCyclin-dependent kinase 22.7.11.220.523
1g5sI17Cyclin-dependent kinase 22.7.11.220.521
4ek610KCyclin-dependent kinase 22.7.11.220.521
4eor4SPCyclin-dependent kinase 22.7.11.220.521
2c5yMTWCyclin-dependent kinase 22.7.11.220.519
3qtuX44Cyclin-dependent kinase 22.7.11.220.519
3ral04ZCyclin-dependent kinase 22.7.11.220.519
2c6kDT2Cyclin-dependent kinase 22.7.11.220.518
2b52D42Cyclin-dependent kinase 22.7.11.220.517
3r7iX9ICyclin-dependent kinase 22.7.11.220.517
2bheBRYCyclin-dependent kinase 22.7.11.220.515
3rak03ZCyclin-dependent kinase 22.7.11.220.515
1v1k3FPCyclin-dependent kinase 22.7.11.220.514
2iw84SPCyclin-dependent kinase 22.7.11.220.514
3qqkX02Cyclin-dependent kinase 22.7.11.220.514
4eok4SPCyclin-dependent kinase 22.7.11.220.514
4lyn1YGCyclin-dependent kinase 22.7.11.220.513
1h1r6CPCyclin-dependent kinase 22.7.11.220.512
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.512
3qqfX07Cyclin-dependent kinase 22.7.11.220.512
3r6xX84Cyclin-dependent kinase 22.7.11.220.512
3s1h56ZCyclin-dependent kinase 22.7.11.220.511
4erwSTUCyclin-dependent kinase 22.7.11.220.511
1pyePM1Cyclin-dependent kinase 22.7.11.220.510
3r8vZ62Cyclin-dependent kinase 22.7.11.220.510
1gii1PUCyclin-dependent kinase 22.7.11.220.509
1vyzN5BCyclin-dependent kinase 22.7.11.220.509
3r7eX88Cyclin-dependent kinase 22.7.11.220.509
3r7uX96Cyclin-dependent kinase 22.7.11.220.509
3r9hZ67Cyclin-dependent kinase 22.7.11.220.509
3roy22ZCyclin-dependent kinase 22.7.11.220.509
3qzhX69Cyclin-dependent kinase 22.7.11.220.508
3r8pZ46Cyclin-dependent kinase 22.7.11.220.507
3raiX85Cyclin-dependent kinase 22.7.11.220.507
1ke9LS5Cyclin-dependent kinase 22.7.11.220.506
2wpa889Cyclin-dependent kinase 22.7.11.220.506
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.505
3qxpX64Cyclin-dependent kinase 22.7.11.220.505
2w17I19Cyclin-dependent kinase 22.7.11.220.504
3unj0BXCyclin-dependent kinase 22.7.11.220.504
1di8DTQCyclin-dependent kinase 22.7.11.220.503
3r83Z14Cyclin-dependent kinase 22.7.11.220.503
1y8yCT7Cyclin-dependent kinase 22.7.11.220.502
3qruX19Cyclin-dependent kinase 22.7.11.220.502
3s0o50ZCyclin-dependent kinase 22.7.11.220.502
3ti1B49Cyclin-dependent kinase 22.7.11.220.502
1ke5LS1Cyclin-dependent kinase 22.7.11.220.501
1unlRRCCyclin-dependent-like kinase 52.7.11.10.501
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.501
1oiuN76Cyclin-dependent kinase 22.7.11.220.500
1oi9N20Cyclin-dependent kinase 22.7.11.220.499
2btsU32Cyclin-dependent kinase 22.7.11.220.499
3fz1B98Cyclin-dependent kinase 22.7.11.220.499
3r1qX75Cyclin-dependent kinase 22.7.11.220.499
3r7vZ02Cyclin-dependent kinase 22.7.11.220.499
3lfsA07Cyclin-dependent kinase 22.7.11.220.498
3qzfX66Cyclin-dependent kinase 22.7.11.220.498
1oiyN41Cyclin-dependent kinase 22.7.11.220.497
2b55D31Cyclin-dependent kinase 22.7.11.220.497
2bhhRYUCyclin-dependent kinase 22.7.11.220.497
2duv371Cyclin-dependent kinase 22.7.11.220.497
3qwjX6ACyclin-dependent kinase 22.7.11.220.496
3r9oZ71Cyclin-dependent kinase 22.7.11.220.496
4fkg4CKCyclin-dependent kinase 22.7.11.220.496
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.495
1ckpPVBCyclin-dependent kinase 22.7.11.220.494
2c6lDT4Cyclin-dependent kinase 22.7.11.220.494
1pxoCK7Cyclin-dependent kinase 22.7.11.220.493
3qqlX03Cyclin-dependent kinase 22.7.11.220.493
3rk507ZCyclin-dependent kinase 22.7.11.220.493
4fx360KCyclin-dependent kinase 22.7.11.220.492
1fvv107Cyclin-dependent kinase 22.7.11.220.491
1oiqHDUCyclin-dependent kinase 22.7.11.220.491
3ddqRRCCyclin-dependent kinase 22.7.11.220.491
3qzgX67Cyclin-dependent kinase 22.7.11.220.491
3s00Z60Cyclin-dependent kinase 22.7.11.220.491
2uzbC75Cyclin-dependent kinase 22.7.11.220.489
2xnbY8LCyclin-dependent kinase 22.7.11.220.489
3qtqX35Cyclin-dependent kinase 22.7.11.220.488
3ddpRC8Cyclin-dependent kinase 22.7.11.220.487
4fklCK2Cyclin-dependent kinase 22.7.11.220.487
2vthLZ2Cyclin-dependent kinase 22.7.11.220.486
2b53D23Cyclin-dependent kinase 22.7.11.220.485
3r28XA0Cyclin-dependent kinase 22.7.11.220.485
3r9nZ68Cyclin-dependent kinase 22.7.11.220.485
3rahO1ZCyclin-dependent kinase 22.7.11.220.485
2ds11CDCyclin-dependent kinase 22.7.11.220.484
3rpo24ZCyclin-dependent kinase 22.7.11.220.484
1b39ATPCyclin-dependent kinase 22.7.11.220.483
1fvt106Cyclin-dependent kinase 22.7.11.220.483
2wihP48Cyclin-dependent kinase 22.7.11.220.483
4eon1ROCyclin-dependent kinase 22.7.11.220.483
3qrtX14Cyclin-dependent kinase 22.7.11.220.482
4kd11QKCyclin-dependent kinase 22.7.11.220.482
3rkb12ZCyclin-dependent kinase 22.7.11.220.481
3wblPDYCyclin-dependent kinase 22.7.11.220.481
4bcmT7ZCyclin-dependent kinase 22.7.11.220.481
1dm2HMDCyclin-dependent kinase 22.7.11.220.480
4ez30S0Cyclin-dependent kinase 22.7.11.220.480
1w8cN69Cyclin-dependent kinase 22.7.11.220.478
2uzlC94Cyclin-dependent kinase 22.7.11.220.478
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.478
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.478
2r3gSC9Cyclin-dependent kinase 22.7.11.220.477
1h1q2A6Cyclin-dependent kinase 22.7.11.220.476
1vyw292Cyclin-dependent kinase 22.7.11.220.476
2iw94SPCyclin-dependent kinase 22.7.11.220.475
1pkdUCNCyclin-dependent kinase 22.7.11.220.474
3nynSGVG protein-coupled receptor kinase 62.7.11.160.474
1v0pPVBCell division control protein 2 homolog2.7.11.220.473
2fvdLIACyclin-dependent kinase 22.7.11.220.473
2pvlP55Casein kinase II subunit alpha2.7.11.10.473
3qwkX62Cyclin-dependent kinase 22.7.11.220.472
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.472
2uzeC95Cyclin-dependent kinase 22.7.11.220.469
4bcpT3CCyclin-dependent kinase 22.7.11.220.469
3ig7EFPCyclin-dependent kinase 22.7.11.220.468
3sheI85MAP kinase-activated protein kinase 32.7.11.10.468
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.468
1gij2PUCyclin-dependent kinase 22.7.11.220.467
1ke8LS4Cyclin-dependent kinase 22.7.11.220.467
2vtrLZBCyclin-dependent kinase 22.7.11.220.467
2vttLZDCyclin-dependent kinase 22.7.11.220.467
2c6mDT5Cyclin-dependent kinase 22.7.11.220.466
3ql8X01Cyclin-dependent kinase 22.7.11.220.466
4eomATPCyclin-dependent kinase 22.7.11.220.466
2r3fSC8Cyclin-dependent kinase 22.7.11.220.465
2wxvWXVCyclin-dependent kinase 22.7.11.220.465
3qqgX06Cyclin-dependent kinase 22.7.11.220.464
3rpy27ZCyclin-dependent kinase 22.7.11.220.464
1xjdSTUProtein kinase C theta type2.7.11.130.463
2pvhP19Casein kinase II subunit alpha2.7.11.10.463
3dogNNNCyclin-dependent kinase 22.7.11.220.463
1e9hINRCyclin-dependent kinase 22.7.11.220.462
3ggfGVDSerine/threonine-protein kinase 26/0.462
3qtrX36Cyclin-dependent kinase 22.7.11.220.462
3r8zZ63Cyclin-dependent kinase 22.7.11.220.462
1eh4IC1Casein kinase I homolog 12.7.11.10.461
4fki09KCyclin-dependent kinase 22.7.11.220.461
1h1pCMGCyclin-dependent kinase 22.7.11.220.460
2b54D05Cyclin-dependent kinase 22.7.11.220.460
2pvnP63Casein kinase II subunit alpha2.7.11.10.460
2vtsLZCCyclin-dependent kinase 22.7.11.220.460
3be9P04Casein kinase II subunit alpha2.7.11.10.460
3qx2X63Cyclin-dependent kinase 22.7.11.220.460
3qziX72Cyclin-dependent kinase 22.7.11.220.459
3tiz3TICyclin-dependent kinase 22.7.11.220.459
1v0oINRCell division control protein 2 homolog2.7.11.220.458
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.458
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.458
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.458
5dr6SKEAurora kinase A2.7.11.10.458
3my5RFZCyclin-dependent kinase 22.7.11.220.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
2bkzSBCCyclin-dependent kinase 22.7.11.220.455
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.455
2exmZIPCyclin-dependent kinase 22.7.11.220.454
2i40BLZCyclin-dependent kinase 22.7.11.220.454
2vu3LZECyclin-dependent kinase 22.7.11.220.454
4dgnLU2Casein kinase II subunit alpha2.7.11.10.453
1b38ATPCyclin-dependent kinase 22.7.11.220.452
1hckATPCyclin-dependent kinase 22.7.11.220.452
4bcoT6QCyclin-dependent kinase 22.7.11.220.452
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.448
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.448
3uli1N3Cyclin-dependent kinase 22.7.11.220.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
2b7aIZATyrosine-protein kinase JAK2/0.447
2c5nCK8Cyclin-dependent kinase 22.7.11.220.447
2c69CT8Cyclin-dependent kinase 22.7.11.220.447
2vtqLZACyclin-dependent kinase 22.7.11.220.447
1r78FMDCyclin-dependent kinase 22.7.11.220.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.446
3r8uZ31Cyclin-dependent kinase 22.7.11.220.446
4qmpDKISerine/threonine-protein kinase 242.7.11.10.446
3nux3NVCyclin-dependent kinase 62.7.11.220.445
4cfnJYMCyclin-dependent kinase 22.7.11.220.445
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.445
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.443
3pe2E1BCasein kinase II subunit alpha2.7.11.10.443
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.443
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.442
2dwbANPAurora kinase A2.7.11.10.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3rpr25ZCyclin-dependent kinase 22.7.11.220.440