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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.31.000
1ju6LYAThymidylate synthase2.1.1.450.526
1jujLYAThymidylate synthase2.1.1.450.507
4ez8DHFThymidylate synthase2.1.1.450.501
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.479
1tduCB3Thymidylate synthase/0.469
1hvyD16Thymidylate synthase2.1.1.450.466
1jutLYDThymidylate synthase/0.466
1ci7CB3Thymidylate synthase2.1.1.450.461
1jtqLY3Thymidylate synthase/0.454
2tscCB3Thymidylate synthase/0.453
1bq1CB3Thymidylate synthase/0.447
1dnaCB3Thymidylate synthase/0.447
1kceCB3Thymidylate synthase/0.446
4eb4D16Thymidylate synthase2.1.1.450.441
2aazCB3Thymidylate synthase2.1.1.450.440
3bgxMEFThymidylate synthase/0.440