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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ehzJAKTyrosine-protein kinase JAK1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ehzJAKTyrosine-protein kinase JAK1/1.000
4fk60UJTyrosine-protein kinase JAK1/0.592
4i5cC5ITyrosine-protein kinase JAK1/0.588
4e6d0NUTyrosine-protein kinase JAK2/0.580
4e4n0NLTyrosine-protein kinase JAK1/0.572
4e5w0NTTyrosine-protein kinase JAK1/0.564
4ji91M3Tyrosine-protein kinase JAK2/0.557
4hge15VTyrosine-protein kinase JAK2/0.546
4e4l0NHTyrosine-protein kinase JAK1/0.542
2vv9IM9Cyclin-dependent kinase 22.7.11.220.536
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.535
4aqc88ATyrosine-protein kinase JAK2/0.535
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.529
4e6q0NVTyrosine-protein kinase JAK2/0.528
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.527
4ei40Q2Tyrosine-protein kinase JAK1/0.523
4f081RSTyrosine-protein kinase JAK2/0.523
4ivb1J5Tyrosine-protein kinase JAK1/0.517
1ykr628Cyclin-dependent kinase 22.7.11.220.515
3eyhIZATyrosine-protein kinase JAK1/0.511
3iok1P6Tyrosine-protein kinase JAK2/0.510
4ivd15TTyrosine-protein kinase JAK1/0.507
4fv6E57Mitogen-activated protein kinase 12.7.11.240.506
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.506
3zh8C58Protein kinase C iota type2.7.11.130.505
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.505
3rak03ZCyclin-dependent kinase 22.7.11.220.503
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.502
4ivc1J6Tyrosine-protein kinase JAK1/0.502
4k771Q4Tyrosine-protein kinase JAK1/0.502
1e1xNW1Cyclin-dependent kinase 22.7.11.220.501
5dt0SKEAurora kinase A2.7.11.10.499
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.497
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.497
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.497
3zep1NXTyrosine-protein kinase JAK32.7.10.20.495
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.494
2hckQUETyrosine-protein kinase HCK2.7.10.20.491
3i60E86Mitogen-activated protein kinase 12.7.11.240.491
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.491
5e92ANPTGF-beta receptor type-22.7.11.300.490
4c62XWWTyrosine-protein kinase JAK2/0.489
1p2a5BNCyclin-dependent kinase 22.7.11.220.486
4bbfO19Tyrosine-protein kinase JAK2/0.486
4hvi19STyrosine-protein kinase JAK32.7.10.20.486
3at4CCKCasein kinase II subunit alpha2.7.11.10.485
1urwI1PCyclin-dependent kinase 22.7.11.220.484
3lpbNVBTyrosine-protein kinase JAK2/0.483
1h0w207Cyclin-dependent kinase 22.7.11.220.482
1yvj4STTyrosine-protein kinase JAK32.7.10.20.482
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.482
1oitHDTCyclin-dependent kinase 22.7.11.220.480
2b7aIZATyrosine-protein kinase JAK2/0.480
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.479
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.479
4erwSTUCyclin-dependent kinase 22.7.11.220.478
1w8cN69Cyclin-dependent kinase 22.7.11.220.477
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.477
4dt9GMPAPH(2'')-Id/0.477
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
2r3iSCFCyclin-dependent kinase 22.7.11.220.476
2vu3LZECyclin-dependent kinase 22.7.11.220.476
3eb0DRKUncharacterized protein/0.476
3r83Z14Cyclin-dependent kinase 22.7.11.220.476
4fv9E71Mitogen-activated protein kinase 12.7.11.240.476
3ggfGVDSerine/threonine-protein kinase 26/0.475
3rk708ZCyclin-dependent kinase 22.7.11.220.475
4o0wADNAurora kinase A2.7.11.10.475
5e8ySTUTGF-beta receptor type-22.7.11.300.475
2vthLZ2Cyclin-dependent kinase 22.7.11.220.474
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.474
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.474
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.474
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.473
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.473
3rahO1ZCyclin-dependent kinase 22.7.11.220.473
4fod0UVALK tyrosine kinase receptor2.7.10.10.473
4gmy0X5Tyrosine-protein kinase JAK2/0.473
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.473
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4nifANPMitogen-activated protein kinase 12.7.11.240.472
2fvdLIACyclin-dependent kinase 22.7.11.220.471
3qtuX44Cyclin-dependent kinase 22.7.11.220.471
1bxqPP8Penicillopepsin-13.4.23.200.470
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.470
2ojj82AMitogen-activated protein kinase 12.7.11.240.470
2w17I19Cyclin-dependent kinase 22.7.11.220.470
5dr9SKEAurora kinase A2.7.11.10.470
2c6iDT1Cyclin-dependent kinase 22.7.11.220.469
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.469
3rvg17PTyrosine-protein kinase JAK2/0.469
4hvh19RTyrosine-protein kinase JAK32.7.10.20.469
1pxmCK5Cyclin-dependent kinase 22.7.11.220.468
2dwbANPAurora kinase A2.7.11.10.468
4o0uADNAurora kinase A2.7.11.10.467
1g5sI17Cyclin-dependent kinase 22.7.11.220.466
2xmyCDKCyclin-dependent kinase 22.7.11.220.466
3s1h56ZCyclin-dependent kinase 22.7.11.220.466
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4qnyANPMitogen activated protein kinase, putative/0.466
2y9qANPMitogen-activated protein kinase 12.7.11.240.465
3mtfA3FActivin receptor type-12.7.11.300.465
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.465
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.464
2j9mPY8Cyclin-dependent kinase 22.7.11.220.464
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4fkv61KCyclin-dependent kinase 22.7.11.220.464
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
1gih1PUCyclin-dependent kinase 22.7.11.220.463
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.463
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.463
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.463
2uzoC62Cyclin-dependent kinase 22.7.11.220.463
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.463
3r8vZ62Cyclin-dependent kinase 22.7.11.220.463
4c61LMMTyrosine-protein kinase JAK2/0.463
4dymIYZActivin receptor type-12.7.11.300.463
1eh4IC1Casein kinase I homolog 12.7.11.10.462
1h1r6CPCyclin-dependent kinase 22.7.11.220.462
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.462
4ek816KCyclin-dependent kinase 22.7.11.220.462
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.462
4y93746Tyrosine-protein kinase/0.462
1h1s4SPCyclin-dependent kinase 22.7.11.220.461
1rfuADPPyridoxal kinase2.7.1.350.461
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.461
3nieANPMitogen-activated protein kinase/0.460
3raiX85Cyclin-dependent kinase 22.7.11.220.460
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.460
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.460
1unlRRCCyclin-dependent-like kinase 52.7.11.10.459
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.459
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.459
3qxpX64Cyclin-dependent kinase 22.7.11.220.459
3s2pPMUCyclin-dependent kinase 22.7.11.220.459
3t8oATPRhodopsin kinase/0.459
4bgh3I6Cyclin-dependent kinase 22.7.11.220.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
4k6z1Q3Tyrosine-protein kinase JAK1/0.459
1y91CT9Cyclin-dependent kinase 22.7.11.220.458
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.458
3t113T1Gag-Pol polyprotein3.4.23.160.458
3tnwF18Cyclin-dependent kinase 22.7.11.220.458
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
5dpvSKEAurora kinase A2.7.11.10.458
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.457
2eufLQQCyclin-dependent kinase 62.7.11.220.457
2uzbC75Cyclin-dependent kinase 22.7.11.220.457
2yw2ATPPhosphoribosylamine--glycine ligase/0.457
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.457
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.456
2pvnP63Casein kinase II subunit alpha2.7.11.10.456
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.456
3ncz3NCRho-associated protein kinase 12.7.11.10.456
3rk507ZCyclin-dependent kinase 22.7.11.220.456
4btjATPTau-tubulin kinase 12.7.11.10.456
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.455
3r8lZ30Cyclin-dependent kinase 22.7.11.220.455
3sheI85MAP kinase-activated protein kinase 32.7.11.10.455
4nakPBQ2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic2.7.7.600.455
4q5hANPProtein kinase OspG2.70.455
1lbcCYZGlutamate receptor 2/0.454
1t7j478Gag-Pol polyprotein3.4.23.160.454
2qnqQN3Gag-Pol polyprotein3.4.23.160.454
2xa4AZ5Tyrosine-protein kinase JAK2/0.454
3le62BZCyclin-dependent kinase 22.7.11.220.454
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
3nynSGVG protein-coupled receptor kinase 62.7.11.160.454
3oibFDAPutative acyl-CoA dehydrogenase/0.454
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.454
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.454
3zdu38RCyclin-dependent kinase-like 32.7.11.220.454
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.454
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.454
4s34ANPMitogen-activated protein kinase 12.7.11.240.454
2j0m4STFocal adhesion kinase 12.7.10.20.453
2r3jSCJCyclin-dependent kinase 22.7.11.220.453
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3oom507Activin receptor type-12.7.11.300.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bgg844Activin receptor type-12.7.11.300.453
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.453
4n6hEJ4Delta-type opioid receptor/0.453
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.452
3a62STURibosomal protein S6 kinase beta-12.7.11.10.452
4eomATPCyclin-dependent kinase 22.7.11.220.452
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.452
4h3qANPMitogen-activated protein kinase 12.7.11.240.452
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.452
5cnnANPEpidermal growth factor receptor2.7.10.10.452
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.451
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.451
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.451
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.451
4fko20KCyclin-dependent kinase 22.7.11.220.451
4j5j478Gag-Pol polyprotein3.4.23.160.451
4lyn1YGCyclin-dependent kinase 22.7.11.220.451
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.451
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
1pxlCK4Cyclin-dependent kinase 22.7.11.220.450
3rpo24ZCyclin-dependent kinase 22.7.11.220.450
3w551FMMitogen-activated protein kinase 12.7.11.240.450
1ke6LS2Cyclin-dependent kinase 22.7.11.220.449
1m2pHNACasein kinase II subunit alpha2.7.11.10.449
1qmzATPCyclin-dependent kinase 22.7.11.220.449
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.449
3bc3OPTCathepsin L13.4.22.150.449
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.448
2r3o2SCCyclin-dependent kinase 22.7.11.220.448
3r73X87Cyclin-dependent kinase 22.7.11.220.448
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4hvg19QTyrosine-protein kinase JAK32.7.10.20.448
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.447
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.447
2f2uM77Rho-associated protein kinase 22.7.11.10.447
3iltTRUGlutamate receptor 2/0.447
3r9nZ68Cyclin-dependent kinase 22.7.11.220.447
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4aguD15Cyclin-dependent kinase-like 1/0.447
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.447
4k4p3TLGag-Pol polyprotein/0.447
4zseANPEpidermal growth factor receptor2.7.10.10.447
5cnoANPEpidermal growth factor receptor2.7.10.10.447
1k6vXN2Gag-Pol polyprotein3.4.23.160.446
1msmJE2Gag-Pol polyprotein3.4.23.160.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.446
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.446
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.446
2oapANPType II secretion system protein (GspE-2)/0.446
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.446
3lltANPProtein serine/threonine kinase-1/0.446
3qtrX36Cyclin-dependent kinase 22.7.11.220.446
3qyw6PBMitogen-activated protein kinase 12.7.11.240.446
3rm719ZCyclin-dependent kinase 22.7.11.220.446
4a6nFADTetX family tetracycline inactivation enzyme/0.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4fmqANPMitogen-activated protein kinase 12.7.11.240.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
2bheBRYCyclin-dependent kinase 22.7.11.220.445
2h96893Mitogen-activated protein kinase 82.7.11.240.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3a3gDLZLumazine protein/0.445
4eor4SPCyclin-dependent kinase 22.7.11.220.445
4hgt15GCasein kinase I isoform delta2.7.11.10.445
4iva1J5Tyrosine-protein kinase JAK2/0.445
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.445
1bdlIM1Gag-Pol polyprotein3.4.23.160.444
1bwsNDPGDP-L-fucose synthase/0.444
2gmjFADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial1.5.5.10.444
2p3b3TLV-1 PROTEASE protein/0.444
2p3b3TLV-1 protease/0.444
2r3r6SCCyclin-dependent kinase 22.7.11.220.444
2r64740Cyclin-dependent kinase 22.7.11.220.444
2vtsLZCCyclin-dependent kinase 22.7.11.220.444
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4fkr45KCyclin-dependent kinase 22.7.11.220.444
4jboWPHAurora kinase A2.7.11.10.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.443
1tj2FADBifunctional protein PutA1.5.5.20.443
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.443
3gu83GUDeath-associated protein kinase 12.7.11.10.443
3gxlQIGTGF-beta receptor type-12.7.11.300.443
3sw418KCyclin-dependent kinase 22.7.11.220.443
3vf80JETyrosine-protein kinase SYK2.7.10.20.443
4fklCK2Cyclin-dependent kinase 22.7.11.220.443
4nmbFADBifunctional protein PutA/0.443
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.443
1aq1STUCyclin-dependent kinase 22.7.11.220.442
1ke7LS3Cyclin-dependent kinase 22.7.11.220.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3d1z017Gag-Pol polyprotein3.4.23.160.442
3pcrGTPADP-ribosylation factor 6/0.442
3r1yX76Cyclin-dependent kinase 22.7.11.220.442
3uli1N3Cyclin-dependent kinase 22.7.11.220.442
4c58824Cyclin-G-associated kinase2.7.11.10.442
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.442
4fv8E63Mitogen-activated protein kinase 12.7.11.240.442
4ic7ANPMitogen-activated protein kinase 72.7.11.240.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
1pxpCK8Cyclin-dependent kinase 22.7.11.220.441
1xe55FEPlasmepsin-23.4.23.390.441
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
3litE15Protease/0.441
3rpv26ZCyclin-dependent kinase 22.7.11.220.441
3sw719KCyclin-dependent kinase 22.7.11.220.441
4c3pACPAurora kinase A2.7.11.10.441
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.441
4dgnLU2Casein kinase II subunit alpha2.7.11.10.441
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.441
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.441
4yaiNAIC alpha-dehydrogenase/0.441
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.440
1in5ADPHolliday junction ATP-dependent DNA helicase RuvB/0.440
2bl4NADLactaldehyde reductase1.1.1.770.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
3qtxX43Cyclin-dependent kinase 22.7.11.220.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440
4qmpDKISerine/threonine-protein kinase 242.7.11.10.440
5dr6SKEAurora kinase A2.7.11.10.440