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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eevL1XHepatocyte growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4eevL1XHepatocyte growth factor receptor2.7.10.11.000
3ctj320Hepatocyte growth factor receptor2.7.10.10.564
3ce31FNHepatocyte growth factor receptor2.7.10.10.532
4eyjN61Mitogen-activated protein kinase 132.7.11.240.455
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3eta351Insulin receptor2.7.10.10.449
2p4iMR9Angiopoietin-1 receptor2.7.10.10.446
4kaoKAOFocal adhesion kinase 12.7.10.20.446
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.441