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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/1.000
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.685
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.661
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.658
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.657
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.641
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.629
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.621
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.616
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.610
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.607
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.604
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.594
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.592
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.591
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.585
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.573
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.567
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.555
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.552
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.514
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.504
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
3v94WYQPhosphodiesterase/0.462
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441