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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e6d0NUTyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e6d0NUTyrosine-protein kinase JAK2/1.000
4i5cC5ITyrosine-protein kinase JAK1/0.611
4aqc88ATyrosine-protein kinase JAK2/0.600
4hge15VTyrosine-protein kinase JAK2/0.574
4e4n0NLTyrosine-protein kinase JAK1/0.570
4fv6E57Mitogen-activated protein kinase 12.7.11.240.561
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.556
3lpbNVBTyrosine-protein kinase JAK2/0.546
4f081RSTyrosine-protein kinase JAK2/0.538
4e6q0NVTyrosine-protein kinase JAK2/0.534
4ehzJAKTyrosine-protein kinase JAK1/0.534
4ivb1J5Tyrosine-protein kinase JAK1/0.534
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.531
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.525
4ji91M3Tyrosine-protein kinase JAK2/0.522
4e5w0NTTyrosine-protein kinase JAK1/0.514
3iok1P6Tyrosine-protein kinase JAK2/0.511
2vv9IM9Cyclin-dependent kinase 22.7.11.220.510
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.509
4hvi19STyrosine-protein kinase JAK32.7.10.20.509
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.505
5e8ySTUTGF-beta receptor type-22.7.11.300.500
3eyhIZATyrosine-protein kinase JAK1/0.499
2pvnP63Casein kinase II subunit alpha2.7.11.10.498
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.498
4fk60UJTyrosine-protein kinase JAK1/0.498
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.496
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.495
1yvj4STTyrosine-protein kinase JAK32.7.10.20.494
4ivc1J6Tyrosine-protein kinase JAK1/0.494
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.494
4o0wADNAurora kinase A2.7.11.10.493
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.492
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.490
3be9P04Casein kinase II subunit alpha2.7.11.10.488
1g5sI17Cyclin-dependent kinase 22.7.11.220.487
1ykr628Cyclin-dependent kinase 22.7.11.220.487
2cciATPCyclin-dependent kinase 22.7.11.220.486
4bbfO19Tyrosine-protein kinase JAK2/0.485
3s1h56ZCyclin-dependent kinase 22.7.11.220.484
4dt9GMPAPH(2'')-Id/0.484
4eooATPCyclin-dependent kinase 22.7.11.220.484
4qnyANPMitogen activated protein kinase, putative/0.484
4c61LMMTyrosine-protein kinase JAK2/0.483
2c6iDT1Cyclin-dependent kinase 22.7.11.220.482
3i60E86Mitogen-activated protein kinase 12.7.11.240.482
2pvhP19Casein kinase II subunit alpha2.7.11.10.481
4aguD15Cyclin-dependent kinase-like 1/0.481
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.480
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.478
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.478
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.478
1fvv107Cyclin-dependent kinase 22.7.11.220.477
2b7aIZATyrosine-protein kinase JAK2/0.477
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
4otiMI1Serine/threonine-protein kinase N1/0.477
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
3ncz3NCRho-associated protein kinase 12.7.11.10.476
2j0m4STFocal adhesion kinase 12.7.10.20.475
5dnrATPAurora kinase A2.7.11.10.475
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.474
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.474
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.471
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.470
4y93746Tyrosine-protein kinase/0.470
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.469
4y95746Tyrosine-protein kinase/0.469
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.468
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.467
2pvmP29Casein kinase II subunit alpha2.7.11.10.467
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.467
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.467
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.466
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
3a62STURibosomal protein S6 kinase beta-12.7.11.10.466
3eb0DRKUncharacterized protein/0.466
3rak03ZCyclin-dependent kinase 22.7.11.220.465
3rvg17PTyrosine-protein kinase JAK2/0.465
3zewSTUEphrin type-B receptor 42.7.10.10.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.463
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.463
4btjATPTau-tubulin kinase 12.7.11.10.463
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.463
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.463
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4btjADPTau-tubulin kinase 12.7.11.10.462
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.461
3zh8C58Protein kinase C iota type2.7.11.130.461
3zmmF9JTyrosine-protein kinase JAK2/0.460
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
3at4CCKCasein kinase II subunit alpha2.7.11.10.459
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.459
4jia1K3Tyrosine-protein kinase JAK2/0.459
2w05FRTCyclin-dependent kinase 22.7.11.220.458
2xa4AZ5Tyrosine-protein kinase JAK2/0.458
3nynSGVG protein-coupled receptor kinase 62.7.11.160.458
4anmWULCasein kinase II subunit alpha2.7.11.10.458
4h3qANPMitogen-activated protein kinase 12.7.11.240.458
2vu3LZECyclin-dependent kinase 22.7.11.220.457
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3ggu017Gag-Pol polyprotein3.4.23.160.456
5cvfATPCasein kinase II subunit alpha2.7.11.10.456
1dayGNPCasein kinase II subunit alpha2.7.11.10.455
2ijmADPFocal adhesion kinase 12.7.10.20.455
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4iva1J5Tyrosine-protein kinase JAK2/0.455
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.454
2x6dX6DAurora kinase A2.7.11.10.454
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3gubGUBDeath-associated protein kinase 12.7.11.10.453
3gxlQIGTGF-beta receptor type-12.7.11.300.453
4e4l0NHTyrosine-protein kinase JAK1/0.453
4ivd15TTyrosine-protein kinase JAK1/0.453
5av2KMPDeath-associated protein kinase 12.7.11.10.453
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4bgh3I6Cyclin-dependent kinase 22.7.11.220.452
4deeADPAurora kinase A2.7.11.10.452
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.452
4lrjANPUncharacterized protein/0.452
2vtsLZCCyclin-dependent kinase 22.7.11.220.451
3juhANPCasein kinase II subunit alpha2.7.11.10.451
3lltANPProtein serine/threonine kinase-1/0.451
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.451
1qmzATPCyclin-dependent kinase 22.7.11.220.450
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.450
4nifANPMitogen-activated protein kinase 12.7.11.240.450
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.449
1y91CT9Cyclin-dependent kinase 22.7.11.220.449
2c6lDT4Cyclin-dependent kinase 22.7.11.220.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.449
5dt0SKEAurora kinase A2.7.11.10.449
5e92ANPTGF-beta receptor type-22.7.11.300.449
1m2pHNACasein kinase II subunit alpha2.7.11.10.448
2yaaATPDeath-associated protein kinase 2/0.448
3le62BZCyclin-dependent kinase 22.7.11.220.448
4hvh19RTyrosine-protein kinase JAK32.7.10.20.448
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.447
3t8oATPRhodopsin kinase/0.447
3tnwF18Cyclin-dependent kinase 22.7.11.220.447
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.447
1gii1PUCyclin-dependent kinase 22.7.11.220.446
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
4erwSTUCyclin-dependent kinase 22.7.11.220.446
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.446
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1jklANPDeath-associated protein kinase 12.7.11.10.444
2eufLQQCyclin-dependent kinase 62.7.11.220.444
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.444
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.444
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
1daz0Q4Gag-Pol polyprotein3.4.23.160.443
1pxmCK5Cyclin-dependent kinase 22.7.11.220.443
1pxpCK8Cyclin-dependent kinase 22.7.11.220.443
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4j95ACPFibroblast growth factor receptor 2/0.443
1bygSTUTyrosine-protein kinase CSK/0.442
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.442
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.442
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.442
4o0uADNAurora kinase A2.7.11.10.442
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.441
2fvdLIACyclin-dependent kinase 22.7.11.220.441
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.441
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.441
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.441
1pxoCK7Cyclin-dependent kinase 22.7.11.220.440
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
5dr9SKEAurora kinase A2.7.11.10.440