sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4dvg | GSP | Rho family GTPase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4dvg | GSP | Rho family GTPase | / | 1.000 | |
| 4gzm | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.571 | |
| 2gcp | GSP | Rho-related GTP-binding protein RhoC | / | 0.552 | |
| 2fju | GSP | Ras-related C3 botulinum toxin substrate 1 | / | 0.540 | |
| 2w2x | GSP | Ras-related C3 botulinum toxin substrate 2 | / | 0.538 | |
| 1kmq | GNP | Transforming protein RhoA | / | 0.527 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.525 | |
| 1gwn | GTP | Rho-related GTP-binding protein RhoE | / | 0.522 | |
| 1xtr | GNP | GTP-binding protein Rheb | / | 0.522 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.518 | |
| 1a2b | GSP | Transforming protein RhoA | / | 0.507 | |
| 1cxz | GSP | Transforming protein RhoA | / | 0.506 | |
| 1m7b | GTP | Rho-related GTP-binding protein RhoE | / | 0.503 | |
| 3kz1 | GSP | Transforming protein RhoA | / | 0.503 | |
| 4js0 | GNP | Cell division control protein 42 homolog | / | 0.500 | |
| 1xts | GTP | GTP-binding protein Rheb | / | 0.490 | |
| 3a58 | GNP | GTP-binding protein RHO1 | / | 0.490 | |
| 3oes | GNP | GTPase RhebL1 | / | 0.487 | |
| 2gil | GTP | Ras-related protein Rab-6A | / | 0.486 | |
| 4e03 | ADP | Plasmid partitioning protein ParF | / | 0.486 | |
| 4dzz | ADP | Plasmid partitioning protein ParF | / | 0.483 | |
| 3sbd | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.481 | |
| 1zc4 | GNP | Ras-related protein Ral-A | / | 0.480 | |
| 2cls | GTP | Rho-related GTP-binding protein Rho6 | / | 0.480 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.477 | |
| 3eg5 | GNP | Cell division control protein 42 homolog | / | 0.473 | |
| 1s1c | GNP | Transforming protein RhoA | / | 0.472 | |
| 4cym | GCP | Ras-related protein Rab-32 | / | 0.465 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.463 | |
| 1yzq | GNP | Ras-related protein Rab-6A | / | 0.459 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.458 | |
| 5dha | GNP | GTP-binding nuclear protein Ran | / | 0.458 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.455 | |
| 3a6p | GTP | GTP-binding nuclear protein Ran | / | 0.453 | |
| 4qxa | GTP | Ras-related protein Rab-9A | / | 0.453 | |
| 4mit | GTP | Rho-related protein racC | / | 0.452 | |
| 3th5 | GNP | Ras-related C3 botulinum toxin substrate 1 | / | 0.450 | |
| 3tkl | GTP | Ras-related protein Rab-1A | / | 0.449 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.447 | |
| 3tnf | GNP | Ras-related protein Rab-8A | / | 0.446 | |
| 3ref | GDP | Rho family GTPase | / | 0.445 | |
| 4nyi | GNP | GTPase HRas | / | 0.445 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.444 | |
| 2qme | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.444 | |
| 4dlt | GNP | GTPase HRas | / | 0.444 | |
| 1zbd | GTP | Ras-related protein Rab-3A | / | 0.443 | |
| 3law | GNP | Ras-related protein Rab-7a | / | 0.443 | |
| 3rab | GNP | Ras-related protein Rab-3A | / | 0.443 | |
| 1ibr | GNP | GTP-binding nuclear protein Ran | / | 0.442 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.442 | |
| 4kvg | GTP | Ras-related protein Rap-1A | / | 0.441 |