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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dsuGDPGTPase KRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dsuGDPGTPase KRas/1.000
1uadGNPRas-related protein Ral-A/0.598
4dxaGSPRas-related protein Rap-1b/0.595
2cl6CAGGTPase HRas/0.570
4xvrGNPGTPase HRas/0.556
4dsoGSPGTPase KRas/0.551
1zc3GNPRas-related protein Ral-A/0.550
1zc4GNPRas-related protein Ral-A/0.548
2rggGNPGTPase HRas/0.540
4nyiGNPGTPase HRas/0.532
4lucGDPGTPase KRas/0.526
4ldjGDPGTPase KRas/0.521
4nyjGNPGTPase HRas/0.520
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.518
4uj3GNPRas-related protein Rab-11A/0.515
4q02GDPGTPase KRas/0.510
3oivGNPGTPase HRas/0.509
3v4fGNPGTPase HRas/0.508
3x1wGDPRas-related protein Rap-1b/0.505
1lfdGNPGTPase HRas/0.503
3tgpGNPGTPase HRas/0.502
3i3sGNPGTPase HRas/0.497
3rs5GNPGTPase HRas/0.497
3tsoGNPRas-related protein Rab-25/0.497
3kkqGDPRas-related protein M-Ras/0.495
4l8gGDPGTPase KRas/0.491
4l9sGDPGTPase HRas/0.489
2fe4GDPRas-related protein Rab-6B/0.488
4lv6GDPGTPase KRas/0.484
4uj5GNPRas-related protein Rab-11A/0.484
5b2zGNPGTPase HRas/0.484
4kvgGTPRas-related protein Rap-1A/0.482
5dhaGNPGTP-binding nuclear protein Ran/0.482
3qbtGNPRas-related protein Rab-8A/0.481
4q03GDPGTPase KRas/0.479
4epwGDPGTPase KRas/0.478
1g17GNPRas-related protein SEC4/0.477
3ddcGNPGTPase HRas/0.477
3w3zGTPGTP-binding nuclear protein Ran/0.476
1zbdGTPRas-related protein Rab-3A/0.475
4hdqGNPRas-related protein Rap-1b/0.475
1m7bGTPRho-related GTP-binding protein RhoE/0.474
1xtsGTPGTP-binding protein Rheb/0.474
4xvqGNPGTPase HRas/0.474
4ql3GDPGTPase KRas/0.473
4tq9GDPGTPase KRas/0.472
1kmqGNPTransforming protein RhoA/0.471
4qxaGTPRas-related protein Rab-9A/0.471
4epxGDPGTPase KRas/0.470
4dltGNPGTPase HRas/0.469
4k81GTPGTPase HRas/0.469
5c46GSPRas-related protein Rab-11A/0.468
1z0aGDPRas-related protein Rab-2A/0.467
2ce2GDPGTPase HRas/0.466
4lpkGDPGTPase KRas/0.466
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.465
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.465
3lbnGNPGTPase HRas/0.464
3oiuGNPGTPase HRas/0.464
5hpyGDPTransforming protein RhoA/0.463
3eg5GNPCell division control protein 42 homolog/0.461
1cxzGSPTransforming protein RhoA/0.460
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.460
3k9lGNPGTPase HRas/0.459
3bbpGTPRas-related protein Rab-6A/0.458
4dlwGNPGTPase HRas/0.458
3kucGDPRas-related protein Rap-1A/0.457
3mjhGTPRas-related protein Rab-5A/0.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
2zetGTPRas-related protein Rab-27B/0.455
1ibrGNPGTP-binding nuclear protein Ran/0.453
5jljGNPGTP-binding nuclear protein Ran/0.452
4lrwGDPGTPase KRas/0.451
4obeGDPGTPase KRas/0.450
1e96GTPRas-related C3 botulinum toxin substrate 1/0.449
1yzqGNPRas-related protein Rab-6A/0.449
3kkoGNPRas-related protein M-Ras/0.449
3oesGNPGTPase RhebL1/0.449
1a2bGSPTransforming protein RhoA/0.447
1tu3GNPRas-related protein Rab-5A/0.447
3nga3NGCasein kinase II subunit alpha2.7.11.10.447
1n6lGTPRas-related protein Rab-5A/0.443
3nbzGTPGTP-binding nuclear protein Ran/0.443
4qo9627Serine/threonine-protein kinase 242.7.11.10.443
4lhwGNPRas-related protein Rab-8A/0.442
4wa7GDPGTPase KRas/0.442
4rkfGNPRas-related protein Rab-3/0.441