scPDB - Distribution of Binding site Similarity values of 4dph entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	1.000
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.610
3qly	55V	Uncharacterized protein	/	0.591
3cse	N22	Uncharacterized protein	/	0.590
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.588
4dp3	MMV	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.585
1j3k	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.580
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.567
3eej	53R	Uncharacterized protein	/	0.561
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.556
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.552
4h98	14Q	Uncharacterized protein	/	0.549
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.546
3eel	53T	Uncharacterized protein	/	0.545
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.545
3eek	53S	Uncharacterized protein	/	0.544
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.543
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.542
3qlx	QLR	Uncharacterized protein	/	0.542
3eem	53V	Uncharacterized protein	/	0.540
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.532
3qlz	QLZ	Uncharacterized protein	/	0.532
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.531
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.529
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.527
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.524
2zza	FOL	Dihydrofolate reductase	/	0.519
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.517
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.515
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.509
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.509
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.506
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.504
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.501
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.498
3jwm	5WB	Dihydrofolate reductase	/	0.495
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.494
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.493
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.492
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.492
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.491
4p66	MTX	Dihydrofolate reductase	/	0.489
1hfr	MOT	Dihydrofolate reductase	1.5.1.3	0.486
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.486
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.485
4eil	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.485
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.485
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.484
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.484
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.484
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.482
4ky4	04J	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.482
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.482
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.481
4kak	06U	Dihydrofolate reductase	1.5.1.3	0.481
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.478
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.477
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.477
3ghw	GHW	Dihydrofolate reductase	1.5.1.3	0.477
3jw5	TOP	Dihydrofolate reductase	/	0.477
3rg9	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.477
1kms	LIH	Dihydrofolate reductase	1.5.1.3	0.473
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.472
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.472
3sni	546	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.472
3sa2	7DR	Dihydrofolate reductase	/	0.470
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.469
4keb	FOL	Dihydrofolate reductase	1.5.1.3	0.469
3ghv	GHC	Dihydrofolate reductase	1.5.1.3	0.468
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.468
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.468
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
3qg2	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.467
1soj	IBM	cGMP-inhibited 3',5'-cyclic phosphodiesterase B	3.1.4.17	0.466
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.466
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.466
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.466
1dyr	TOP	Dihydrofolate reductase	1.5.1.3	0.465
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.462
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.461
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.461
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.461
3tq9	MTX	Dihydrofolate reductase	/	0.461
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.460
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.460
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.459
4kjj	FOL	Dihydrofolate reductase	1.5.1.3	0.459
3gyf	51P	Dihydrofolate reductase	1.5.1.3	0.458
3sa1	6DR	Dihydrofolate reductase	/	0.458
3um8	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.458
1boz	PRD	Dihydrofolate reductase	1.5.1.3	0.457
3dat	MTX	Dihydrofolate reductase	/	0.457
4ddl	0JQ	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.457
1ohj	COP	Dihydrofolate reductase	1.5.1.3	0.456
2w3w	VG9	Dihydrofolate reductase	/	0.456
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.456
4ddr	MMV	Dihydrofolate reductase	1.5.1.3	0.456
2vn0	TDZ	Cytochrome P450 2C8	/	0.455
2w3m	FOL	Dihydrofolate reductase	1.5.1.3	0.455
3gi2	GHW	Dihydrofolate reductase	1.5.1.3	0.455
3fl8	RAR	Dihydrofolate reductase	/	0.454
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
4j7x	SAS	Sepiapterin reductase	1.1.1.153	0.453
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.453
5dc5	B3N	Histone deacetylase 8	3.5.1.98	0.453
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.451
1kmv	LII	Dihydrofolate reductase	1.5.1.3	0.451
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.451
3d3p	20A	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.450
3tqb	FOL	Dihydrofolate reductase	/	0.450
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	0.450
1u72	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.448
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.447
3hf6	LX0	Tryptophan 5-hydroxylase 1	1.14.16.4	0.447
3sn7	540	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	3.1.4.17	0.447
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.446
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.446
3g4i	D71	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.446
3itu	IBM	cGMP-dependent 3',5'-cyclic phosphodiesterase	3.1.4.17	0.446
3vtc	TK3	Vitamin D3 receptor	/	0.446
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.445
3nxr	D2D	Dihydrofolate reductase	1.5.1.3	0.445
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.444
1ly4	COQ	Dihydrofolate reductase	1.5.1.3	0.444
3u8h	BHP	Phospholipase A2, membrane associated	/	0.444
3vt7	VDX	Vitamin D3 receptor	/	0.444
4ib4	ERM	5-hydroxytryptamine receptor 2B	/	0.444
4j7u	YTZ	Sepiapterin reductase	1.1.1.153	0.444
4qa2	SHH	Histone deacetylase 8	3.5.1.98	0.443
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.442
3k47	D09	Dihydrofolate reductase	1.5.1.3	0.442
3srs	M23	Dihydrofolate reductase	1.5.1.3	0.442
4fjz	4FJ	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.442
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.441
2w6o	OA3	Biotin carboxylase	6.3.4.14	0.441
3o56	ZG1	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	3.1.4.53	0.441
4rbs	0RV	Metallo-beta-lactamase type 2	/	0.441
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.440