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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dnaFADProbable glutathione reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dnaFADProbable glutathione reductase/1.000
2jk6FADTrypanothione reductase/0.654
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.604
4la1FADThioredoxin glutathione reductase/0.602
1febFADTrypanothione reductase1.8.1.120.598
1tytFADTrypanothione reductase1.8.1.120.585
2hqmFADGlutathione reductase1.8.1.70.584
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.581
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.579
1fecFADTrypanothione reductase1.8.1.120.577
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.577
1greFADGlutathione reductase, mitochondrial1.8.1.70.576
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.576
2r9zFADGlutathione amide reductase/0.571
1grgFADGlutathione reductase, mitochondrial1.8.1.70.563
1grhFADGlutathione reductase, mitochondrial1.8.1.70.563
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.562
4nevFADTrypanothione reductase/0.562
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.560
1gerFADGlutathione reductase1.8.1.70.551
3grsFADGlutathione reductase, mitochondrial1.8.1.70.546
1bzlFADTrypanothione reductase1.8.1.120.538
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.537
1typFADTrypanothione reductase1.8.1.120.536
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.534
2v6oFADThioredoxin glutathione reductase/0.533
2wbaFADTrypanothione reductase1.8.1.120.533
1gxfFADTrypanothione reductase1.8.1.120.522
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.513
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.507
4j56FADThioredoxin reductase 21.8.1.90.507
4j57FADThioredoxin reductase 21.8.1.90.507
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.503
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.502
2wp5FADTrypanothione reductase/0.499
3ladFADDihydrolipoyl dehydrogenase/0.495
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.493
1graFADGlutathione reductase, mitochondrial1.8.1.70.493
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.492
4eqwFADCoenzyme A disulfide reductase/0.486
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.484
1yqzFADCoenzyme A disulfide reductase/0.480
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.470
2eq9FADDihydrolipoyl dehydrogenase/0.468
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.466
1zx9FADMercuric reductase1.16.1.10.466
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.465
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.463
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
3ntaFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.462
2eq6FADDihydrolipoyl dehydrogenase/0.458
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.455
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.455
5er0FADUncharacterized NAD(FAD)-dependent dehydrogenase/0.451
4gavFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.450
2wowFADTrypanothione reductase/0.449
4eqsFADCoenzyme A disulfide reductase/0.449
2eq8FADDihydrolipoyl dehydrogenase/0.445
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.443
2yquFADDihydrolipoyl dehydrogenase/0.442
2a8xFADDihydrolipoyl dehydrogenase1.8.1.40.441
2w0hFADTrypanothione reductase/0.441
3ntdFADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.441