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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/1.000
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.578
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.549
4esoNAPPutative oxidoreductase/0.546
4b79NADProbable short-chain dehydrogenase/0.542
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.537
4j7xNAPSepiapterin reductase1.1.1.1530.519
1g6kNADGlucose 1-dehydrogenase1.1.1.470.516
4nbwNADShort-chain dehydrogenase/reductase SDR/0.515
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.511
1ae1NAPTropinone reductase 1/0.510
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.509
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.508
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.508
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.506
4j7uNAPSepiapterin reductase1.1.1.1530.506
3toxNAPPutative oxidoreductase/0.504
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.503
1geeNADGlucose 1-dehydrogenase1.1.1.470.502
4hwkNAPSepiapterin reductase1.1.1.1530.502
4bmvNAPShort-chain dehydrogenase/0.501
1ipeNDPTropinone reductase 21.1.1.2360.499
4qecNAPElxO/0.499
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.498
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.498
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.497
1w4zNAPPutative ketoacyl reductase1.3.10.496
1xkqNDPUncharacterized protein/0.496
3ai2NDPNADPH-sorbose reductase/0.495
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.494
3w8dNAD3-hydroxybutyrate dehydrogenase/0.493
1x7hNDPPutative ketoacyl reductase1.3.10.492
5idwNAPShort-chain dehydrogenase/reductase SDR/0.490
3l77NJPShort-chain alcohol dehydrogenase/0.489
1xg5NAPDehydrogenase/reductase SDR family member 11/0.488
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.488
1rwbNADGlucose 1-dehydrogenase1.1.1.470.487
1oaaNAPSepiapterin reductase1.1.1.1530.485
3vdqNAD3-hydroxybutyrate dehydrogenase/0.484
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.483
3gy0NAPNAD(P)-dependent oxidoreductase/0.483
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.482
3bmoNAPPteridine reductase/0.481
5jlaNADPutative short-chain dehydrogenase/reductase/0.481
1gcoNADGlucose 1-dehydrogenase1.1.1.470.480
3qrwNDPPutative ketoacyl reductase1.3.10.480
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.479
3f1kNAPUncharacterized oxidoreductase YciK10.478
3p19NDPPutative blue fluorescent protein/0.478
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.477
4dc1NDPPutative ketoacyl reductase1.3.10.477
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.476
3ai3NDPNADPH-sorbose reductase/0.475
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.475
1n5dNDPCarbonyl reductase [NADPH] 1/0.473
3sjuNDPKeto reductase/0.470
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.470
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.470
1x7gNAPPutative ketoacyl reductase1.3.10.469
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.469
3w8eNAD3-hydroxybutyrate dehydrogenase/0.469
3wdsNADNADH-dependent quinuclidinone reductase/0.469
2bd0NAPSepiapterin reductase/0.468
3tn7NJPShort-chain alcohol dehydrogenase/0.468
3w8fNAD3-hydroxybutyrate dehydrogenase/0.467
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.466
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.466
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.465
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.465
4yaiNAIC alpha-dehydrogenase/0.465
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.464
1snyNAPLD36273p/0.462
3lqfNADGalactitol dehydrogenase/0.462
3s55NADPutative short-chain dehydrogenase/reductase/0.462
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.461
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
1wntNAPL-xylulose reductase1.1.1.100.460
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.460
3ak4NADNADH-dependent quinuclidinone reductase/0.459
3d3wNAPL-xylulose reductase1.1.1.100.459
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.457
4qedNAPElxO/0.457
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.456
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.454
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
2yutNAPPutative short-chain oxidoreductase/0.453
4yagNAIC alpha-dehydrogenase/0.453
1pr9NAPL-xylulose reductase1.1.1.100.452
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.452
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
2dteNAIGlucose 1-dehydrogenase related protein/0.449
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.447
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.447
4fn4NADShort chain dehydrogenase/0.447
2yy7NADL-threonine dehydrogenase/0.446
5lc1NADL-threonine 3-dehydrogenase/0.446
2bfoNDPPteridine reductase 11.5.1.330.445
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
1sbyNADAlcohol dehydrogenase1.1.1.10.444
4b8wNAPGDP-L-fucose synthase1.1.1.2710.444
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.443
1kevNDPNADP-dependent isopropanol dehydrogenase1.1.1.800.441
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.441
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.440