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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dlwGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dlwGNPGTPase HRas/1.000
3v4fGNPGTPase HRas/0.753
4dltGNPGTPase HRas/0.724
3rs0GNPGTPase HRas/0.722
3rslGNPGTPase HRas/0.719
4dlvGNPGTPase HRas/0.713
3lbnGNPGTPase HRas/0.710
4dlxGNPGTPase HRas/0.704
3rs5GNPGTPase HRas/0.702
2rgcGNPGTPase HRas/0.700
2rgeGNPGTPase HRas/0.685
3ddcGNPGTPase HRas/0.678
4dlzGNPGTPase HRas/0.675
2rgbGNPGTPase HRas/0.670
3lbhGNPGTPase HRas/0.663
3rs7GNPGTPase HRas/0.654
3oivGNPGTPase HRas/0.646
3i3sGNPGTPase HRas/0.645
4lhwGNPRas-related protein Rab-8A/0.634
3oiuGNPGTPase HRas/0.633
4rkfGNPRas-related protein Rab-3/0.632
2c5lGTPGTPase HRas/0.617
4nyiGNPGTPase HRas/0.615
3rs4GNPGTPase HRas/0.612
4k81GTPGTPase HRas/0.609
3pitGNPRas-related protein M-Ras/0.608
3x1zGNPRas-related protein Rap-1b/0.608
4l9wGNPGTPase HRas/0.606
5b2zGNPGTPase HRas/0.606
4l9sGDPGTPase HRas/0.603
3rabGNPRas-related protein Rab-3A/0.602
3k8yGNPGTPase HRas/0.600
3lbiGNPGTPase HRas/0.597
3kkoGNPRas-related protein M-Ras/0.595
3l8yGNPGTPase HRas/0.594
1e96GTPRas-related C3 botulinum toxin substrate 1/0.593
3a6pGTPGTP-binding nuclear protein Ran/0.592
1t91GTPRas-related protein Rab-7a/0.587
3ea5GDPGTP-binding nuclear protein Ran/0.586
4dsnGCPGTPase KRas/0.585
3kucGDPRas-related protein Rap-1A/0.583
3kudGDPGTPase HRas/0.581
3oiwGNPGTPase HRas/0.578
4mitGTPRho-related protein racC/0.578
4nyjGNPGTPase HRas/0.574
1yhnGTPRas-related protein Rab-7a/0.573
1yzqGNPRas-related protein Rab-6A/0.571
3oesGNPGTPase RhebL1/0.571
4g0nGNPGTPase HRas/0.570
1ibrGNPGTP-binding nuclear protein Ran/0.569
4qxaGTPRas-related protein Rab-9A/0.569
3w3zGTPGTP-binding nuclear protein Ran/0.568
3bc1GNPRas-related protein Rab-27A/0.567
4hdoGNPRas-related protein Rap-1b/0.566
5jljGNPGTP-binding nuclear protein Ran/0.564
3tsoGNPRas-related protein Rab-25/0.562
1vg8GNPRas-related protein Rab-7a/0.561
3e5hGNPRas-related protein Rab-28/0.560
3bbpGTPRas-related protein Rab-6A/0.558
1g17GNPRas-related protein SEC4/0.557
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.555
5difGNPGTP-binding nuclear protein Ran/0.554
3nbzGTPGTP-binding nuclear protein Ran/0.553
3a58GNPGTP-binding protein RHO1/0.545
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.544
2zetGTPRas-related protein Rab-27B/0.544
1oixGDPRas-related protein Rab-11A/0.542
4dlsGNPGTPase HRas/0.542
1kmqGNPTransforming protein RhoA/0.539
2fe4GDPRas-related protein Rab-6B/0.539
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.539
5dhaGNPGTP-binding nuclear protein Ran/0.538
3tnfGNPRas-related protein Rab-8A/0.537
2bkuGTPGTP-binding nuclear protein Ran/0.536
4o25GTPGTP-binding protein Rheb/0.534
2gilGTPRas-related protein Rab-6A/0.533
4dxaGSPRas-related protein Rap-1b/0.533
1ow3GDPTransforming protein RhoA/0.530
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.528
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.527
4dsoGSPGTPase KRas/0.526
1k5dGNPGTP-binding nuclear protein Ran/0.525
3th5GNPRas-related C3 botulinum toxin substrate 1/0.524
4ol0GTPGTP-binding nuclear protein Ran/0.524
1cxzGSPTransforming protein RhoA/0.523
1a2bGSPTransforming protein RhoA/0.521
4epwGDPGTPase KRas/0.521
5hpyGDPTransforming protein RhoA/0.521
1zbdGTPRas-related protein Rab-3A/0.520
3lawGNPRas-related protein Rab-7a/0.520
4uj3GNPRas-related protein Rab-11A/0.518
1xtrGNPGTP-binding protein Rheb/0.517
1xtsGTPGTP-binding protein Rheb/0.515
4hdqGNPRas-related protein Rap-1b/0.513
1zd9GDPADP-ribosylation factor-like protein 8A/0.512
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.511
1m7bGTPRho-related GTP-binding protein RhoE/0.505
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.505
1lfdGNPGTPase HRas/0.504
2gcpGSPRho-related GTP-binding protein RhoC/0.504
3kz1GSPTransforming protein RhoA/0.503
4l8gGDPGTPase KRas/0.501
2msdGNPMHC class I alpha chain/0.500
4kvgGTPRas-related protein Rap-1A/0.500
1z2aGDPRas-related protein Rab-23/0.499
4wa7GDPGTPase KRas/0.499
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.498
3wyfGTPGTP-binding nuclear protein/0.497
4obeGDPGTPase KRas/0.497
1d5cGDPGTPase (Rab6)/0.496
4o2lGTPGTP-binding protein Rheb/0.495
1zc3GNPRas-related protein Ral-A/0.494
1zc4GNPRas-related protein Ral-A/0.492
3qbtGNPRas-related protein Rab-8A/0.492
4tq9GDPGTPase KRas/0.491
3cphGDPRas-related protein SEC4/0.490
4xoiGTPTransforming protein RhoA/0.489
1s1cGNPTransforming protein RhoA/0.487
4xvrGNPGTPase HRas/0.487
4epxGDPGTPase KRas/0.486
4lv6GDPGTPase KRas/0.485
4q03GDPGTPase KRas/0.485
2ffqGSPRas-related protein Rab-6B/0.481
4ql3GDPGTPase KRas/0.481
4uj5GNPRas-related protein Rab-11A/0.480
2cl6CAGGTPase HRas/0.479
3mjhGTPRas-related protein Rab-5A/0.479
4cymGCPRas-related protein Rab-32/0.479
4dsuGDPGTPase KRas/0.479
4gzlGNPRas-related C3 botulinum toxin substrate 1/0.479
3tgpGNPGTPase HRas/0.478
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.476
4ldjGDPGTPase KRas/0.475
2ce2GDPGTPase HRas/0.473
4lucGDPGTPase KRas/0.473
1z0dGDPRas-related protein Rab-5C/0.472
4lpkGDPGTPase KRas/0.468
4js0GNPCell division control protein 42 homolog/0.467
5c46GSPRas-related protein Rab-11A/0.466
2clsGTPRho-related GTP-binding protein Rho6/0.465
2fg5GNPRas-related protein Rab-31/0.464
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.463
3x1wGDPRas-related protein Rap-1b/0.463
4xvqGNPGTPase HRas/0.463
3tklGTPRas-related protein Rab-1A/0.462
3kkqGDPRas-related protein M-Ras/0.461
4o2rGDPGTP-binding protein Rheb/0.461
1z2cGNPRho-related GTP-binding protein RhoC/0.460
1yu9GNPRas-related protein Rab-4A/0.458
1uadGNPRas-related protein Ral-A/0.457
2rggGNPGTPase HRas/0.454
4cidANPEH domain-containing protein 2/0.452
4q02GDPGTPase KRas/0.452
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.450
1z0aGDPRas-related protein Rab-2A/0.448
4eb5PLPCysteine desulfurase IscS 2/0.448
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.447
4ead0NPThymidine phosphorylase2.4.2.40.446
4iji99TGlutathione S-transferase-like protein YibF/0.444
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.442
4gyy12VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.442
1g16GDPRas-related protein SEC4/0.440