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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.585
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.581
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.580
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.563
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.543
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.541
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.533
4qnyANPMitogen activated protein kinase, putative/0.521
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
5dnrATPAurora kinase A2.7.11.10.506
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.504
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.492
3c4zADPRhodopsin kinase/0.491
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3wfjNAD2-dehydropantoate 2-reductase/0.486
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.485
4ysjADPCalmodulin-like domain protein kinase/0.485
1dayGNPCasein kinase II subunit alpha2.7.11.10.484
5iqiGNPBifunctional AAC/APH2.3.10.484
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.481
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
5iqgGDPBifunctional AAC/APH2.3.10.477
1jkkANPDeath-associated protein kinase 12.7.11.10.475
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
1qmzATPCyclin-dependent kinase 22.7.11.220.470
5iqeGNPBifunctional AAC/APH2.3.10.469
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
1ig1ANPDeath-associated protein kinase 12.7.11.10.465
3c4wATPRhodopsin kinase/0.465
3qc9ADPRhodopsin kinase/0.465
4xlvACPInsulin receptor2.7.10.10.465
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4i3zADPCyclin-dependent kinase 22.7.11.220.464
5bylGCPBifunctional AAC/APH2.3.10.463
5iqhGNPBifunctional AAC/APH2.3.10.463
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4deeADPAurora kinase A2.7.11.10.462
3fhiANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.458
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.458
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4orkGDPBifunctional AAC/APH2.3.10.457
2w4jADPDeath-associated protein kinase 12.7.11.10.455
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.452
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.451
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1dawANPCasein kinase II subunit alpha2.7.11.10.450
3gu7ADPDeath-associated protein kinase 12.7.11.10.450
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.450
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4ii5ADPCyclin-dependent kinase 22.7.11.220.449
5dosATPAurora kinase A2.7.11.10.448
1h6aNDPGlucose--fructose oxidoreductase1.1.99.280.447
5cvfATPCasein kinase II subunit alpha2.7.11.10.447
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3c4xATPRhodopsin kinase/0.446
4s33ANPMitogen-activated protein kinase 12.7.11.240.444
5kgpACOPredicted acetyltransferase/0.443
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2henADPEphrin type-B receptor 22.7.10.10.441
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440