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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4df2FMNNADPH dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4df2FMNNADPH dehydrogenase/1.000
4qaiFMNNADPH dehydrogenase/0.608
4m5pFMNNADPH dehydrogenase/0.605
3tjlFMNNADPH dehydrogenase/0.557
1h50FMNPentaerythritol tetranitrate reductase/0.549
3p67FMNPentaerythritol tetranitrate reductase/0.547
3f03FMNPentaerythritol tetranitrate reductase/0.540
3p74FMNPentaerythritol tetranitrate reductase/0.537
2abbFMNPentaerythritol tetranitrate reductase/0.536
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.536
1vyrFMNPentaerythritol tetranitrate reductase/0.535
1icqFMN12-oxophytodienoate reductase 11.3.1.420.531
3p62FMNPentaerythritol tetranitrate reductase/0.528
1bwlFMNNADPH dehydrogenase 11.6.99.10.526
1h63FMNPentaerythritol tetranitrate reductase/0.524
1h51FMNPentaerythritol tetranitrate reductase/0.523
1icpFMN12-oxophytodienoate reductase 11.3.1.420.522
1icsFMN12-oxophytodienoate reductase 11.3.1.420.517
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.513
3p84FMNPentaerythritol tetranitrate reductase/0.507
3p8jFMNPentaerythritol tetranitrate reductase/0.505
4tmcFMNOld yellow enzyme/0.497
1bwkFMNNADPH dehydrogenase 11.6.99.10.488
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.486
4h6kFMNNADPH dehydrogenase 11.6.99.10.486
4jicFMNGTN Reductase/0.486
4tmbFMNOld yellow enzyme/0.486
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.484
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.483
3p8iFMNPentaerythritol tetranitrate reductase/0.481
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.480
1szfFMNCytochrome b2, mitochondrial1.1.2.30.479
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.479
3l5lFMNXenobiotic reductase/0.479
3atzFMNProstaglandin F2a synthase/0.478
3p82FMNPentaerythritol tetranitrate reductase/0.478
4awtFMNNADH:flavin oxidoreductase Sye1/0.473
4rnuFMNNADPH dehydrogenase 11.6.99.10.469
1szgFNSCytochrome b2, mitochondrial1.1.2.30.468
2iyfERYOleandomycin glycosyltransferase2.4.10.468
4rnwFMNNADPH dehydrogenase 11.6.99.10.468
4qnwFMNChanoclavine-I aldehyde reductase easA/0.467
1oycFMNNADPH dehydrogenase 11.6.99.10.466
4uthFMNXenobiotic reductase/0.466
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.465
1fcbFMNCytochrome b2, mitochondrial1.1.2.30.463
3atyFMNProstaglandin F2a synthase/0.463
3hyoADPPyridoxal kinase/0.463
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.462
2wf3ZY3Beta-secretase 13.4.23.460.461
4e2bFMNDehydrogenase/0.461
4awsFMNNADH:flavin oxidoreductase Sye1/0.460
3dm6757Beta-secretase 13.4.23.460.459
1oyaFMNNADPH dehydrogenase 11.6.99.10.458
1q45FMN12-oxophytodienoate reductase 31.3.1.420.458
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.458
2gjlFMNNitronate monooxygenase1.13.12.160.457
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.456
1psa0ZLPepsin A3.4.23.10.455
4e2dFMNDehydrogenase/0.455
4irnFADAnaB/0.455
4k7yFMNNADPH dehydrogenase 11.6.99.10.455
4loi1YCStimulator of interferon genes protein/0.455
4rnxFMNNADPH dehydrogenase 11.6.99.10.455
1yb5NAPQuinone oxidoreductase1.6.5.50.454
2g1r3IGRenin3.4.23.150.454
3lpkZ76Beta-secretase 13.4.23.460.454
4bfzZVZPantothenate kinase2.7.1.330.453
4dpf0LGBeta-secretase 13.4.23.460.453
1j49NADD-lactate dehydrogenase1.1.1.280.450
3lpiZ74Beta-secretase 13.4.23.460.449
3qe2FMNNADPH--cytochrome P450 reductase/0.449
4eb7PLPCysteine desulfurase IscS 2/0.449
4fm80UQBeta-secretase 13.4.23.460.449
1f8fNADBenzyl alcohol dehydrogenase/0.448
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.448
2rcyNAPPyrroline-5-carboxylate reductase/0.448
2wnsOMPUridine 5'-monophosphate synthase2.4.2.100.448
3imgBZ2Pantothenate synthetase6.3.2.10.448
3ohh3HHBeta-secretase 13.4.23.460.448
2qbuSAHPrecorrin-2 methyltransferase/0.447
2wf1ZY1Beta-secretase 13.4.23.460.447
3cic316Beta-secretase 13.4.23.460.447
3h3t16HCollagen type IV alpha-3-binding protein/0.446
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4q71FADBifunctional protein PutA/0.446
2b8l5HABeta-secretase 13.4.23.460.445
3ixj586Beta-secretase 13.4.23.460.445
4egbNADdTDP-glucose 4,6-dehydratase/0.445
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.444
2wezZYEBeta-secretase 13.4.23.460.444
3gw9VNILanosterol 14-alpha-demethylase/0.444
3oixFMNDihydroorotate dehydrogenase/0.444
4djaFAD(6-4) photolyase/0.444
1udaUFGUDP-glucose 4-epimerase5.1.3.20.443
1x1aSAMC-20 methyltransferase/0.443
4m83ERYOleandomycin glycosyltransferase2.4.10.443
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.442
1w6hTITPlasmepsin-23.4.23.390.442
1xe55FEPlasmepsin-23.4.23.390.442
2dftADPShikimate kinase2.7.1.710.442
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.442
2ilvC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.442
2oapANPType II secretion system protein (GspE-2)/0.442
4lol1YEStimulator of interferon genes protein/0.442
3fhyATPPyridoxal kinase2.7.1.350.441
3gkaFMNN-ethylmaleimide reductase/0.441
3tr05GPGuanylate kinase/0.441
4ambDUDPutative glycosyl transferase/0.441
4i6gFADCryptochrome-2/0.441
2g1y5IGRenin3.4.23.150.440
3d91REMRenin3.4.23.150.440
3n14FMNXenobiotic reductase/0.440
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4lxa1YSBeta-secretase 13.4.23.460.440