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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4demYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4demYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.721
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.706
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.644
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.631
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.578
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.554
3iczPB6Farnesyl pyrophosphate synthase/0.525
3egt722Farnesyl pyrophosphate synthase/0.506
3dyh721Farnesyl pyrophosphate synthase/0.493
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.487
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.484
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.464
3rywK9HFarnesyl pyrophosphate synthase, putative/0.459
3up0D7SaceDAF-12/0.457
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.452
2iqgF2IBeta-secretase 13.4.23.460.445
1n83CLRNuclear receptor ROR-alpha/0.444
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.443
5iqiGNPBifunctional AAC/APH2.3.10.443
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4nieNBHNuclear receptor ROR-gamma/0.440