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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dce0JFALK tyrosine kinase receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dce0JFALK tyrosine kinase receptor2.7.10.11.000
4fnzNZFALK tyrosine kinase receptor2.7.10.10.647
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.558
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.554
2xp2VGHALK tyrosine kinase receptor2.7.10.10.553
4nks2M2Fibroblast growth factor receptor 1/0.546
3w2sW2REpidermal growth factor receptor2.7.10.10.538
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.535
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.533
4nka2K7Fibroblast growth factor receptor 1/0.532
4f640S8Fibroblast growth factor receptor 1/0.529
3s4qNK0Mitogen-activated protein kinase 14/0.525
2hog710Serine/threonine-protein kinase Chk12.7.11.10.521
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.517
3eta351Insulin receptor2.7.10.10.513
4eym0RXMitogen-activated protein kinase 132.7.11.240.513
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.511
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.510
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.509
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.507
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.507
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.506
2itzIREEpidermal growth factor receptor2.7.10.10.506
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.506
4i231C9Epidermal growth factor receptor2.7.10.10.506
1xkkFMMEpidermal growth factor receptor2.7.10.10.505
1zyjBI5Mitogen-activated protein kinase 14/0.505
2itqITQEpidermal growth factor receptor2.7.10.10.505
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.505
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.504
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.503
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.502
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.501
4fob0USALK tyrosine kinase receptor2.7.10.10.501
3tubFPUTyrosine-protein kinase SYK2.7.10.20.500
4j97ACPFibroblast growth factor receptor 2/0.500
5aaaVGHALK tyrosine kinase receptor2.7.10.10.500
1m17AQ4Epidermal growth factor receptor2.7.10.10.499
2fgiPD1Fibroblast growth factor receptor 1/0.499
3js2VM1Fibroblast growth factor receptor 1/0.499
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.498
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.498
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.497
4c62XWWTyrosine-protein kinase JAK2/0.497
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.497
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.495
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
4jrvKJVEpidermal growth factor receptor2.7.10.10.494
2eb3ANPEpidermal growth factor receptor2.7.10.10.493
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.493
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.493
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.492
2of4979Tyrosine-protein kinase Lck2.7.10.20.492
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.491
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.491
3ctj320Hepatocyte growth factor receptor2.7.10.10.491
4f630S7Fibroblast growth factor receptor 1/0.491
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.491
4kaoKAOFocal adhesion kinase 12.7.10.20.491
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.491
3w33W19Epidermal growth factor receptor2.7.10.10.490
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.490
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.490
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.489
4cd0AWJALK tyrosine kinase receptor2.7.10.10.489
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.489
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.489
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.488
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.488
4hvh19RTyrosine-protein kinase JAK32.7.10.20.488
2itwITQEpidermal growth factor receptor2.7.10.10.487
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.487
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.487
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.487
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.486
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.486
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.486
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.486
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.486
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.485
4ic7ANPMitogen-activated protein kinase 72.7.11.240.485
1wvxBD4Death-associated protein kinase 12.7.11.10.484
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.484
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
4eevL1XHepatocyte growth factor receptor2.7.10.10.484
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.484
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.483
1w84L12Mitogen-activated protein kinase 14/0.483
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.483
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.483
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.482
3emg685Tyrosine-protein kinase SYK2.7.10.20.482
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.482
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.481
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.481
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.481
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.481
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.481
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.480
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.480
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.480
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.480
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.480
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.479
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.479
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.478
3poz03PEpidermal growth factor receptor2.7.10.10.478
4jr3KJREpidermal growth factor receptor2.7.10.10.478
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.477
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.477
4fx360KCyclin-dependent kinase 22.7.11.220.477
2q0bACPFibroblast growth factor receptor 2/0.476
3uvqFS8Mitogen-activated protein kinase 14/0.476
4ib4ERM5-hydroxytryptamine receptor 2B/0.476
1di9MSQMitogen-activated protein kinase 14/0.475
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.475
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.475
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.475
4jq7KJQEpidermal growth factor receptor2.7.10.10.475
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.474
3vjoANPEpidermal growth factor receptor2.7.10.10.474
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.474
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.473
1zg32HIIsoflavone 4'-O-methyltransferase/0.473
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.473
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.473
3nwq2NCGag-Pol polyprotein3.4.23.160.473
3uvp048Mitogen-activated protein kinase 14/0.473
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.472
4gapFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.472
1yw2PGJMitogen-activated protein kinase 14/0.471
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.471
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.471
3p4tFAOPutative acyl-CoA dehydrogenase/0.471
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.471
4anqVGHALK tyrosine kinase receptor2.7.10.10.471
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.471
4jq8KJ8Epidermal growth factor receptor2.7.10.10.471
1k6pXN3Gag-Pol polyprotein3.4.23.160.470
2c6eHPMAurora kinase A2.7.11.10.470
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.470
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.470
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.469
2hk51BMTyrosine-protein kinase HCK2.7.10.20.469
2pzrACPFibroblast growth factor receptor 2/0.469
3a62STURibosomal protein S6 kinase beta-12.7.11.10.469
3bhy7CPDeath-associated protein kinase 3/0.469
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.469
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.468
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.468
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
3vjnANPEpidermal growth factor receptor2.7.10.10.468
4fmqANPMitogen-activated protein kinase 12.7.11.240.468
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.468
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.468
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.468
4izy1J2Mitogen-activated protein kinase 82.7.11.240.468
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.467
2itxANPEpidermal growth factor receptor2.7.10.10.467
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.467
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.467
4hvg19QTyrosine-protein kinase JAK32.7.10.20.467
4id71G0Activated CDC42 kinase 1/0.467
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.466
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.466
2j0k4STFocal adhesion kinase 12.7.10.20.466
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.466
3ztxZTXAurora kinase B-A2.7.11.10.466
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.466
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.466
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.466
4iaq2GM5-hydroxytryptamine receptor 1B/0.466
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.466
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.466
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.466
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
1agwSU2Fibroblast growth factor receptor 1/0.465
2pwlACPFibroblast growth factor receptor 2/0.465
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.465
3igoANPCalmodulin-domain protein kinase 1, putative/0.465
3t14FADSulfide-quinone reductase/0.465
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.465
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.464
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.464
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.464
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.464
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.464
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.464
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.464
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.464
4jboWPHAurora kinase A2.7.11.10.464
1y0s331Peroxisome proliferator-activated receptor delta/0.463
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3livE16Protease/0.463
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3w0aDS5Vitamin D3 receptor/0.463
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.463
1k6cMK1Gag-Pol polyprotein3.4.23.160.462
1lhvNOGSex hormone-binding globulin/0.462
2of2547Tyrosine-protein kinase Lck2.7.10.20.462
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4d58BI9Focal adhesion kinase 12.7.10.20.462
4k9yK9YFocal adhesion kinase 12.7.10.20.462
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2ckeIQUDeath-associated protein kinase 2/0.461
2iluNDPLactaldehyde dehydrogenase1.2.1.220.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.461
3nwxKVSGag-Pol polyprotein3.4.23.160.461
3vs3VSETyrosine-protein kinase HCK2.7.10.20.461
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4a9mP9MBromodomain-containing protein 2/0.461
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.461
4gu94GUFocal adhesion kinase 12.7.10.20.461
4k41ATPActin, alpha skeletal muscle/0.461
4xldBRLPeroxisome proliferator-activated receptor gamma/0.461
1oecAA2Fibroblast growth factor receptor 2/0.460
1ouy094Mitogen-activated protein kinase 14/0.460
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.460
2p55MRADual specificity mitogen-activated protein kinase kinase 12.7.12.20.460
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.460
3syiFADSulfide-quinone reductase/0.460
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.460
4ansVGHALK tyrosine kinase receptor2.7.10.10.460
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.460
1k6tXN1Gag-Pol polyprotein3.4.23.160.459
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.459
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.459
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.459
3os33OSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.459
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.458
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
2xba571ALK tyrosine kinase receptor2.7.10.10.458
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.458
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.458
2yfxVGHALK tyrosine kinase receptor2.7.10.10.458
3bc3OPTCathepsin L13.4.22.150.458
3liqE14Protease/0.458
3q92XNBKetohexokinase/0.458
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.458
3wxyCOAUncharacterized protein/0.458
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.458
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1zys199Serine/threonine-protein kinase Chk12.7.11.10.457
2vrx447Aurora kinase B-A2.7.11.10.457
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.457
3tu5ATPActin, alpha skeletal muscle/0.457
4c4h7RODual specificity protein kinase TTK2.7.12.10.457
4f9mFCMPeroxisome proliferator-activated receptor gamma/0.457
4fnyI3KALK tyrosine kinase receptor2.7.10.10.457
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.457
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.457
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.456
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.456
2ittAEEEpidermal growth factor receptor2.7.10.10.456
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.456
3a7hATPSerine/threonine-protein kinase 242.7.11.10.456
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.456
3qaiXNNKetohexokinase/0.456
3w2rW2REpidermal growth factor receptor2.7.10.10.456
3zk5Z18Cytochrome P450 monooxygenase PikC/0.456
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.456
4ez50RSCyclin-dependent kinase 62.7.11.220.456
4fto3HKSerine/threonine-protein kinase Chk12.7.11.10.456
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.456
4gk3L87Ephrin type-A receptor 32.7.10.10.456
4iteTEYVitamin D3 receptor/0.456
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.455
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.455
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.455
4btkDTQTau-tubulin kinase 12.7.11.10.455
3reyXACAdenosine receptor A2a/0.455
1chwHXCChalcone synthase 22.3.1.740.454
1hckATPCyclin-dependent kinase 22.7.11.220.454
3bqr4RBDeath-associated protein kinase 3/0.454
3eb0DRKUncharacterized protein/0.454
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3tnwF18Cyclin-dependent kinase 22.7.11.220.454
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.454
3wd7COAAcridone synthase/0.454
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.454
4hys1BJMitogen-activated protein kinase 82.7.11.240.454
4hyu1BKMitogen-activated protein kinase 82.7.11.240.454
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.453
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3gfeP37Mitogen-activated protein kinase 14/0.453
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.453
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.453
4bcqTJFCyclin-dependent kinase 22.7.11.220.453
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.453
2fy5SOPCholine O-acetyltransferase2.3.1.60.452
2itnANPEpidermal growth factor receptor2.7.10.10.452
2j7t274Serine/threonine-protein kinase 102.7.11.10.452
2xvdAS6Ephrin type-B receptor 42.7.10.10.452
3cgoJNOMitogen-activated protein kinase 102.7.11.240.452
3kpkFADSulfide-quinone reductase/0.452
3q5iANPProtein kinase, putative/0.452
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.452
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.452
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.452
5dr9SKEAurora kinase A2.7.11.10.452
1aq1STUCyclin-dependent kinase 22.7.11.220.451
1w2xRCPAcetyl-CoA carboxylase/0.451
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.451
2c7xNRBCytochrome P450 monooxygenase PikC/0.451
2itpAEEEpidermal growth factor receptor2.7.10.10.451
2vgpAD6Aurora kinase B-A2.7.11.10.451
2vwu7X1Ephrin type-B receptor 42.7.10.10.451
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.451
2znnS44Peroxisome proliferator-activated receptor alpha/0.451
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.451
3nwyGTPUridylate kinase/0.451
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.451
4eh50OMMitogen-activated protein kinase 14/0.451
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.451
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.451
4fyn0VETyrosine-protein kinase SYK2.7.10.20.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.450
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.450
1sstCOASerine acetyltransferase2.3.1.300.450
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.450
1yvj4STTyrosine-protein kinase JAK32.7.10.20.450
2npaMMBPeroxisome proliferator-activated receptor alpha/0.450
2py3ACPFibroblast growth factor receptor 2/0.450
2wouZZFTGF-beta receptor type-12.7.11.300.450
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.450
3gu6ADPDeath-associated protein kinase 12.7.11.10.450
3l8p0CEAngiopoietin-1 receptor2.7.10.10.450
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.450
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.450
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.450
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4brxKGWFocal adhesion kinase 12.7.10.20.450
4c4g7RODual specificity protein kinase TTK2.7.12.10.450
4c4iX20Dual specificity protein kinase TTK2.7.12.10.450
4njt017Protease/0.450
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.450
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.449
1tvoFRZMitogen-activated protein kinase 12.7.11.240.449
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.449
2hasC3OVitamin D3 receptor/0.449
2q61SF1Peroxisome proliferator-activated receptor gamma/0.449
2uy0HV1Gag-Pol polyprotein3.4.23.160.449
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.449
2x7gPVBSRSF protein kinase 22.7.11.10.449
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.449
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.449
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.449
3kduNKSPeroxisome proliferator-activated receptor alpha/0.449
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.449
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.449
5auwQUEDeath-associated protein kinase 12.7.11.10.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.448
1pmv537Mitogen-activated protein kinase 102.7.11.240.448
1r6g442Thyroid hormone receptor beta/0.448
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2qnpQN2Gag-Pol polyprotein3.4.23.160.448
2w05FRTCyclin-dependent kinase 22.7.11.220.448
3em4DR7Gag-Pol polyprotein3.4.23.160.448
3fmn530Mitogen-activated protein kinase 14/0.448
3hllI45Mitogen-activated protein kinase 14/0.448
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.448
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.448
3t2yFADSulfide-quinone reductase/0.448
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4i4e1BQFocal adhesion kinase 12.7.10.20.448
4jbqVX6Aurora kinase A2.7.11.10.448
5awmANPStress-activated protein kinase JNK2.7.11.240.448
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.447
1ictT44Transthyretin/0.447
1sh9RITGag-Pol polyprotein3.4.23.160.447
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.447
1zrzBI1Protein kinase C iota type2.7.11.130.447
2ath3EAPeroxisome proliferator-activated receptor gamma/0.447
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.447
2cciATPCyclin-dependent kinase 22.7.11.220.447
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.447
2po7CHDFerrochelatase, mitochondrial4.99.1.10.447
2xru400Aurora kinase A2.7.11.10.447
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.447
3vt3VDXVitamin D3 receptor/0.447
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
4an92P7Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.447
4o0sADNAurora kinase A2.7.11.10.447
5ap57RODual specificity protein kinase TTK2.7.12.10.447
5e8xSTUTGF-beta receptor type-12.7.11.300.447
1kxpATPActin, alpha skeletal muscle/0.446
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.446
1re9DSOCamphor 5-monooxygenase1.14.15.10.446
3crzFADFerredoxin--NADP+ reductase/0.446
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.446
3orn3ORDual specificity mitogen-activated protein kinase kinase 12.7.12.20.446
3tmz06XCytochrome P450 2B41.14.14.10.446
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.446
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.446
4xlvACPInsulin receptor2.7.10.10.446
1fm9570Peroxisome proliferator-activated receptor gamma/0.445
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
2bheBRYCyclin-dependent kinase 22.7.11.220.445
2j0j4STFocal adhesion kinase 12.7.10.20.445
2uw6GVOcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.445
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.445
3s85LK0Gag-Pol polyprotein/0.445
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.445
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.445
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.445
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.445
4q73FADBifunctional protein PutA/0.445
1k7l544Peroxisome proliferator-activated receptor alpha/0.444
1nmdATPMajor actin/0.444
1t44ATPActin, alpha skeletal muscle/0.444
1txiTX5Vitamin D3 receptor/0.444
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.444
2duv371Cyclin-dependent kinase 22.7.11.220.444
2i0dMUTProtease/0.444
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.444
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.444
2pywADPMethylthioribose kinase2.7.1.1000.444
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.444
2uxuNARHTH-type transcriptional regulator TtgR/0.444
3flsFLSMitogen-activated protein kinase 14/0.444
3l0lHC3Nuclear receptor ROR-gamma/0.444
3lctADPALK tyrosine kinase receptor2.7.10.10.444
3sa323XProtease/0.444
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.444
3w2o03PEpidermal growth factor receptor2.7.10.10.444
3zep1NXTyrosine-protein kinase JAK32.7.10.20.444
3zsh469Mitogen-activated protein kinase 14/0.444
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.444
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.444
4hjoAQ4Epidermal growth factor receptor2.7.10.10.444
4k42ADPActin, alpha skeletal muscle/0.444
4qnaX11Serine/threonine-protein kinase 242.7.11.10.444
1ie9VDXVitamin D3 receptor/0.443
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.443
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.443
1xl2189Gag-Pol polyprotein3.4.23.160.443
2aquDR7Gag-Pol polyprotein3.4.23.160.443
2i40BLZCyclin-dependent kinase 22.7.11.220.443
2r5tANPSerine/threonine-protein kinase Sgk12.7.11.10.443
2xa4AZ5Tyrosine-protein kinase JAK2/0.443
2znoS44Peroxisome proliferator-activated receptor gamma/0.443
3ac1KZITyrosine-protein kinase Lck2.7.10.20.443
3b2tM33Fibroblast growth factor receptor 2/0.443
3oibFDAPutative acyl-CoA dehydrogenase/0.443
3vjhJ35Peroxisome proliferator-activated receptor gamma/0.443
3vt7VDXVitamin D3 receptor/0.443
4anbYQYDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.443
4ia3BIVVitamin D3 receptor A/0.443
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.443
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.443
1wvySTUDeath-associated protein kinase 12.7.11.10.442
2rg5279Mitogen-activated protein kinase 14/0.442
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.442
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3d7tSTUTyrosine-protein kinase CSK/0.442
3opdHIEHeat shock protein 83/0.442
3qlxQLRUncharacterized protein/0.442
3t2zFADSulfide-quinone reductase/0.442
4fv7E94Mitogen-activated protein kinase 12.7.11.240.442
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4hdbG52Gag-Pol polyprotein3.4.23.160.442
4ih8B43Calmodulin-domain protein kinase 1/0.442
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.442
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
1bygSTUTyrosine-protein kinase CSK/0.441
1fvv107Cyclin-dependent kinase 22.7.11.220.441
1hvsA77Gag-Pol polyprotein/0.441
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.441
1k74544Peroxisome proliferator-activated receptor gamma/0.441
1psa0ZLPepsin A3.4.23.10.441
1xqcAEJEstrogen receptor/0.441
2acxANPG protein-coupled receptor kinase 62.7.11.160.441
2ca0PXICytochrome P450 monooxygenase PikC/0.441
2gn9UPGUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.441
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.441
2qnqQN3Gag-Pol polyprotein3.4.23.160.441
2vd5BI8Myotonin-protein kinase2.7.11.10.441
2y9qANPMitogen-activated protein kinase 12.7.11.240.441
2zb0GK3Mitogen-activated protein kinase 14/0.441
3adaNADSubunit alpha of sarocosine oxidase/0.441
3cukFADD-amino-acid oxidase1.4.3.30.441
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.441
3mpt1GKMitogen-activated protein kinase 14/0.441
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4aa0AA0Mitogen-activated protein kinase 14/0.441
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4i3vNADAldehyde dehydrogenase (NAD+)/0.441
4jaqCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.441
4riyADPEpidermal growth factor receptor2.7.10.10.441
1rgiATPActin, alpha skeletal muscle/0.440
1sn0T44Transthyretin/0.440
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.440
1vijBAYGag-Pol polyprotein/0.440
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.440
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2hamC33Vitamin D3 receptor/0.440
2nnpROCProtease/0.440
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3m6gATPActin, alpha skeletal muscle/0.440
3nga3NGCasein kinase II subunit alpha2.7.11.10.440
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3tucFPWTyrosine-protein kinase SYK2.7.10.20.440
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.440
3vrwYS5Vitamin D3 receptor/0.440
3zokNAD3-dehydroquinate synthase, chloroplastic4.2.3.40.440
4an2EUIDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
4b7dQLECytochrome P450 monooxygenase PikC/0.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.440
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4jx1CAHCamphor 5-monooxygenase1.14.15.10.440
4nxwADPMitochondrial dynamics protein MID51/0.440
4r21STRCytochrome P450 family 17 polypeptide 2/0.440
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.440
5ks72BACarnitine transport ATP-binding protein OpuCA3.6.3.320.440