sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 1.000 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.632 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.607 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.586 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.573 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.571 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.565 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.564 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.562 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.561 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.557 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.553 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.550 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.549 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.549 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.548 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.548 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.548 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.547 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.545 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.542 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.538 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.534 | |
| 1iy8 | NAD | Levodione reductase | / | 0.533 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.531 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.529 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.529 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.528 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.527 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.526 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.525 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.525 | |
| 4kwh | NAP | Reductase homolog | / | 0.525 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.524 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.524 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.522 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.522 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.518 | |
| 4qec | NAP | ElxO | / | 0.515 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.514 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.513 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.513 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.513 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.513 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.512 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.511 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.510 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.510 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.510 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.510 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.509 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.509 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.507 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.507 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.506 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.506 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.505 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.505 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.504 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.503 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.502 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.502 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.502 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.502 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.500 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.499 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.499 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.499 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.498 | |
| 3mje | NDP | AmphB | / | 0.497 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.497 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.497 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.497 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.497 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.496 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.496 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.495 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.495 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.495 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.494 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.494 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.493 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.493 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.493 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.490 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.490 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.489 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.489 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.489 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.487 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.486 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.485 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.484 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.484 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.483 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.482 | |
| 3ak4 | NAD | NADH-dependent quinuclidinone reductase | / | 0.482 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.481 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.481 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.481 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.481 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.481 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.480 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.480 | |
| 4hxy | NDP | Plm1 | / | 0.480 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.480 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.479 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.479 | |
| 1sny | NAP | LD36273p | / | 0.477 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.477 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.477 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.476 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.476 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.475 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.474 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.474 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.474 | |
| 3sxp | NAD | ADP-L-glycero-D-mannoheptose-6-epimerase | / | 0.474 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.473 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.473 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.473 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.473 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.472 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.472 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.472 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.471 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.471 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.471 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.471 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.471 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.471 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.470 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.470 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.470 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.470 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.470 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.469 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.468 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.468 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.468 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.468 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.468 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.468 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.468 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.467 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.467 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.467 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.466 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.466 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.466 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.466 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.466 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 4u7w | NDP | MxaA | / | 0.466 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.465 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.465 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.465 | |
| 4kqr | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.465 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.464 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.464 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.463 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.463 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.463 | |
| 3pgx | NAD | Uncharacterized NAD-dependent oxidoreductase MAP_4146 | / | 0.463 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.463 | |
| 5d3q | GDP | Dynamin-1 | 3.6.5.5 | 0.463 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.462 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.462 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3eks | CY9 | Actin-5C | / | 0.461 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.461 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.461 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4kto | FAD | Putative isovaleryl-CoA dehydrogenase protein | / | 0.461 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.460 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.460 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 3bmo | NAP | Pteridine reductase | / | 0.460 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.460 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.459 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.459 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.459 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.459 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.459 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.458 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.458 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.458 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.458 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.458 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.457 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.457 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.457 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.457 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.457 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.457 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.457 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.456 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.456 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.456 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.456 | |
| 3ieu | GDP | GTPase Era | / | 0.456 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.456 | |
| 4l4x | NDP | AmphI | / | 0.456 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.456 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.455 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.455 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.455 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.455 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.455 | |
| 3eku | CY9 | Actin-5C | / | 0.455 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.455 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.454 | |
| 2f81 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.454 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.454 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.454 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.454 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.453 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 3a3g | DLZ | Lumazine protein | / | 0.453 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.453 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.453 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.452 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.452 | |
| 2ydx | NAP | Methionine adenosyltransferase 2 subunit beta | / | 0.452 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.452 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.452 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.452 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.452 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.451 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2bgm | NAJ | Secoisolariciresinol dehydrogenase | 1.1.1.331 | 0.451 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.451 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.451 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.451 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.451 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.451 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.450 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 2z1m | NDP | GDP-mannose 4,6-dehydratase | / | 0.450 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.450 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.450 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.449 | |
| 2abj | CBC | Branched-chain-amino-acid aminotransferase, cytosolic | 2.6.1.42 | 0.449 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.449 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.449 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.449 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.449 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.449 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.449 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.449 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.448 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.448 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.448 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.447 | |
| 2j07 | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.447 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.447 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.447 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.447 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1fk8 | NAD | 3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase | 1.1.1.50 | 0.446 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.446 | |
| 2p3b | 3TL | V-1 protease | / | 0.446 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.446 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.446 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.446 | |
| 5ig2 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.445 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.445 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.445 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.445 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.445 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.445 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.445 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.445 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1gsn | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 1nai | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.444 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.444 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.444 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.444 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.444 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.444 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.444 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.444 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.443 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 4dja | FAD | (6-4) photolyase | / | 0.443 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4kb9 | G79 | Protease | / | 0.443 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1i2b | NAD | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.442 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.442 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.442 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.442 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.441 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.441 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.441 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.441 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.440 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.440 | |
| 1rm4 | NDP | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.440 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 4azy | 7F3 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.440 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.440 |