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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.67

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.671.000
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.463
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.461
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.455
3u4uLNHCasein kinase II subunit alpha2.7.11.10.455
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.453
3at4CCKCasein kinase II subunit alpha2.7.11.10.452
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
3axwTIDCasein kinase II subunit alpha2.7.11.10.450
3t2zFADSulfide-quinone reductase/0.449
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.448
2izrBRKCasein kinase I isoform gamma-32.7.11.10.446
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3t2kFADSulfide-quinone reductase/0.445
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4q72FADBifunctional protein PutA/0.443
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4jia1K3Tyrosine-protein kinase JAK2/0.441