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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4crsAGSSerine/threonine-protein kinase N22.7.11.13

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4crsAGSSerine/threonine-protein kinase N22.7.11.131.000
4qnyANPMitogen activated protein kinase, putative/0.504
4ii5ADPCyclin-dependent kinase 22.7.11.220.465
2cjmATPCyclin-dependent kinase 22.7.11.220.464
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2yaaATPDeath-associated protein kinase 2/0.460
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.459
5dosATPAurora kinase A2.7.11.10.458
5dnrATPAurora kinase A2.7.11.10.455
5cvfATPCasein kinase II subunit alpha2.7.11.10.454
1qmzATPCyclin-dependent kinase 22.7.11.220.453
1jklANPDeath-associated protein kinase 12.7.11.10.451
2cciATPCyclin-dependent kinase 22.7.11.220.451
4eooATPCyclin-dependent kinase 22.7.11.220.450
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3orpAGSSerine/threonine protein kinase/0.448
1jkkANPDeath-associated protein kinase 12.7.11.10.446
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3gu7ADPDeath-associated protein kinase 12.7.11.10.445
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.445
1jstATPCyclin-dependent kinase 22.7.11.220.444
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444