sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4cjs | L0Y | Integrase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4cjs | L0Y | Integrase | / | 1.000 | |
| 4cig | X0P | Integrase | / | 0.674 | |
| 4cif | JDX | Integrase | / | 0.671 | |
| 4cgh | LOZ | Integrase | / | 0.649 | |
| 3zsr | O3N | Integrase | / | 0.645 | |
| 4cez | O3N | Integrase | / | 0.645 | |
| 4cfb | OM3 | Integrase | / | 0.613 | |
| 4cjr | FYM | Integrase | / | 0.609 | |
| 4cj5 | 4VW | Integrase | / | 0.602 | |
| 4cf2 | 3GM | Integrase | / | 0.600 | |
| 3zsv | ZSV | Integrase | / | 0.599 | |
| 4ceb | ZSV | Integrase | / | 0.599 | |
| 3zt0 | ZT0 | Integrase | / | 0.597 | |
| 4cef | D0T | Integrase | / | 0.595 | |
| 4cf0 | O5U | Integrase | / | 0.591 | |
| 4ce9 | O3N | Integrase | / | 0.590 | |
| 4cfc | 7NV | Integrase | / | 0.585 | |
| 3zsy | OM3 | Integrase | / | 0.584 | |
| 4cgj | NZL | Integrase | / | 0.584 | |
| 3zsw | ZSW | Integrase | / | 0.581 | |
| 4ced | 9NS | Integrase | / | 0.578 | |
| 4ceo | G0T | Integrase | / | 0.578 | |
| 4ck1 | OM1 | Integrase | / | 0.578 | |
| 4cjf | RVN | Integrase | / | 0.576 | |
| 4cgg | K5Q | Integrase | / | 0.575 | |
| 4cer | VL4 | Integrase | / | 0.574 | |
| 4cf8 | V7H | Integrase | / | 0.574 | |
| 4cgi | NZL | Integrase | / | 0.572 | |
| 4ck2 | NVU | Integrase | / | 0.571 | |
| 4cju | JNS | Integrase | / | 0.569 | |
| 3zsq | O4N | Integrase | / | 0.563 | |
| 4ces | NFW | Integrase | / | 0.563 | |
| 4cjp | 4D2 | Integrase | / | 0.562 | |
| 4cea | ZSW | Integrase | / | 0.560 | |
| 4cgd | 8P3 | Integrase | / | 0.559 | |
| 4ck3 | K1T | Integrase | / | 0.559 | |
| 4cj3 | E4F | Integrase | / | 0.557 | |
| 3zcm | PX3 | Integrase | / | 0.556 | |
| 4cie | Y7N | Integrase | / | 0.554 | |
| 4cjq | VXO | Integrase | / | 0.553 | |
| 4cee | B0T | Integrase | / | 0.550 | |
| 4cj4 | S3G | Integrase | / | 0.550 | |
| 4cfa | WOP | Integrase | / | 0.546 | |
| 3zsx | N44 | Integrase | / | 0.539 | |
| 3zt2 | ZT2 | Integrase | / | 0.539 | |
| 4chy | C5Q | Integrase | / | 0.538 | |
| 4cjk | H39 | Integrase | / | 0.538 | |
| 3zt3 | ZT4 | Integrase | / | 0.536 | |
| 3zt1 | OM1 | Integrase | / | 0.535 | |
| 3zsz | OM2 | Integrase | / | 0.534 | |
| 4cec | 2SS | Integrase | / | 0.531 | |
| 4cfd | S8Y | Integrase | / | 0.526 | |
| 4ceq | QCH | Integrase | / | 0.518 | |
| 4cje | Q31 | Integrase | / | 0.518 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.507 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.503 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.497 | |
| 4cf1 | IY7 | Integrase | / | 0.497 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.492 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.491 | |
| 4chq | CWU | Integrase | / | 0.489 | |
| 1pox | FAD | Pyruvate oxidase | 1.2.3.3 | 0.485 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.485 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.484 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.481 | |
| 3zdu | 38R | Cyclin-dependent kinase-like 3 | 2.7.11.22 | 0.480 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.479 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.479 | |
| 4cgf | UJ6 | Integrase | / | 0.479 | |
| 1eio | GCH | Gastrotropin | / | 0.477 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.476 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.476 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.476 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1qvn | FRI | Interleukin-2 | / | 0.474 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.474 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.474 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.474 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 5fa5 | MTA | Protein arginine N-methyltransferase 5 | / | 0.473 | |
| 1y5r | C0R | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.471 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.471 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.471 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.470 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.470 | |
| 3mg3 | ECH | Orange carotenoid-binding protein | / | 0.469 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.469 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.468 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.467 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.467 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.466 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.466 | |
| 2yac | 937 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.466 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.465 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.465 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.464 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.464 | |
| 4g56 | SAH | Protein arginine N-methyltransferase 5 | / | 0.464 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.463 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 1z1f | STL | Resveratrol synthase | / | 0.463 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.463 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.463 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.463 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 1pg3 | PRX | Acetyl-coenzyme A synthetase | / | 0.462 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.462 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.462 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.462 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.462 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.461 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.461 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
| 4qer | STL | Phospholipase A2 VRV-PL-VIIIa | / | 0.461 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.460 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.460 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.460 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3ua3 | SAH | Protein arginine N-methyltransferase 5 | / | 0.460 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.460 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.460 | |
| 4oae | CLM | Uncharacterized protein | / | 0.460 | |
| 5ez7 | FAD | Probable FAD-dependent oxidoreductase PA4991 | / | 0.460 | |
| 2bei | ACO | Diamine acetyltransferase 2 | 2.3.1.57 | 0.459 | |
| 3bht | MFR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.459 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.459 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 4lfi | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.459 | |
| 4lva | 20M | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.459 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2p7z | OHT | Estrogen-related receptor gamma | / | 0.458 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.458 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.458 | |
| 5hg0 | SAM | Pantothenate synthetase | / | 0.458 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.457 | |
| 2e9p | 77A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2p2q | PRX | Acetyl-coenzyme A synthetase | / | 0.457 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4qo9 | 627 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.457 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.456 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.456 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.456 | |
| 4ct1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.456 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1ppj | ANY | Cytochrome b | / | 0.455 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.455 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.455 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.455 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.455 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.455 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4iae | 1DX | Alr2278 protein | / | 0.455 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.455 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.455 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.454 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.454 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.454 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.454 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 4ng2 | OHN | Transcriptional activator protein LasR | / | 0.454 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.454 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.453 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.453 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.453 | |
| 2xvu | 9DN | Serum albumin | / | 0.453 | |
| 2ydj | YDJ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 3a6q | FMN | FMN-binding protein | / | 0.453 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.453 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.453 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.452 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.452 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 4d9t | 0JG | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.452 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.452 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.452 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.451 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.451 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.451 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.451 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.451 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.451 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.451 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.451 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.451 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1dcy | I3N | Phospholipase A2, membrane associated | / | 0.450 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.450 | |
| 1ya3 | STR | Mineralocorticoid receptor | / | 0.450 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.450 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.450 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.450 | |
| 4de5 | 0JD | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.450 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.450 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.449 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.449 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.449 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.449 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.449 | |
| 3wec | AUI | Cytochrome P450 | / | 0.449 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.449 | |
| 4lg5 | A1O | Abscisic acid receptor PYL2 | / | 0.449 | |
| 4mq2 | 2C4 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.449 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.449 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.448 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.448 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.448 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.448 | |
| 1tvc | FDA | Methane monooxygenase component C | 1.14.13.25 | 0.448 | |
| 2p2b | PRX | Acetyl-coenzyme A synthetase | / | 0.448 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.448 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.448 | |
| 3qfr | FMN | NADPH--cytochrome P450 reductase | / | 0.448 | |
| 4bz7 | B3N | Histone deacetylase | / | 0.448 | |
| 4dkv | 0KW | Envelope glycoprotein gp160 | / | 0.448 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.448 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.448 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 3r02 | UNM | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 4b1f | KRH | Glutamate racemase | / | 0.447 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.447 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 4z4p | SAH | Histone-lysine N-methyltransferase 2D | 2.1.1.43 | 0.447 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 1nue | GDP | Nucleoside diphosphate kinase B | 2.7.4.6 | 0.446 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.446 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2uv0 | OHN | Transcriptional activator protein LasR | / | 0.446 | |
| 2vtj | LZ4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.446 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3p9t | TCL | Repressor | / | 0.446 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.446 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.446 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 4ozn | ATP | Ammonium transporter | / | 0.446 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.445 | |
| 1own | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 1pag | FMP | Antiviral protein I | 3.2.2.22 | 0.445 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.445 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3cps | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.445 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.445 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3gu8 | 3GU | Death-associated protein kinase 1 | 2.7.11.1 | 0.445 | |
| 4gqb | 0XU | Protein arginine N-methyltransferase 5 | / | 0.445 | |
| 4in4 | 4ID | Kelch-like ECH-associated protein 1 | / | 0.445 | |
| 4itf | TFY | Vitamin D3 receptor | / | 0.445 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.445 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.444 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1owm | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.444 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.444 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.444 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.444 | |
| 2bjh | FER | Feruloyl esterase A | 3.1.1.73 | 0.444 | |
| 2dxf | GNP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.444 | |
| 2imp | NAI | Lactaldehyde dehydrogenase | 1.2.1.22 | 0.444 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.444 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.444 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.444 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.444 | |
| 3ukr | CKH | Actin-related protein 3 | / | 0.444 | |
| 3ukr | CKH | Actin-related protein 2 | / | 0.444 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.444 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.444 | |
| 4pd6 | URI | Nucleoside permease | / | 0.444 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.444 | |
| 6adh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.443 | |
| 1skg | VAL_ALA_PHE_ARG_SER | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.443 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2bxm | IMN | Serum albumin | / | 0.443 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.443 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.443 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.443 | |
| 3lfm | 3DT | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.443 | |
| 3ows | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.443 | |
| 3pd3 | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.443 | |
| 3vy2 | FMN | FMN-binding protein | / | 0.443 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.443 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.443 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 4ys2 | 2BA | Uncharacterized protein | / | 0.443 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.442 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.442 | |
| 1e7w | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.442 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.442 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.442 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.442 | |
| 2ohv | NHL | Glutamate racemase | / | 0.442 | |
| 2r3p | 3SC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2zzn | SAM | tRNA (guanine(37)-N1)-methyltransferase Trm5b | 2.1.1.228 | 0.442 | |
| 3g8e | IS1 | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.442 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.442 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.442 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 3qbt | GNP | Ras-related protein Rab-8A | / | 0.442 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4i4b | 1CV | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.442 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4z28 | BTN | Hoefavidin | / | 0.442 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.441 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.441 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.441 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.441 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.441 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 3oia | A31 | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.441 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1gyp | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.440 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.440 | |
| 1lwl | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1r2j | FAD | FkbI | / | 0.440 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.440 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.440 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.440 | |
| 2hj3 | FAD | FAD-linked sulfhydryl oxidase ERV1 | / | 0.440 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2jfz | 003 | Glutamate racemase | / | 0.440 | |
| 2oyf | IAC | Basic phospholipase A2 VRV-PL-VIIIa | 3.1.1.4 | 0.440 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.440 | |
| 3a6r | FMN | FMN-binding protein | / | 0.440 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.440 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3gob | HXX | DdmC | / | 0.440 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.440 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.440 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3r35 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.440 | |
| 3r7e | X88 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 3vy5 | FMN | FMN-binding protein | / | 0.440 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4apu | OR8 | Progesterone receptor | / | 0.440 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.440 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.440 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.440 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.440 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.440 | |
| 4xrg | NAD | Homospermidine synthase | 2.5.1.44 | 0.440 |