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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4cesNFWIntegrase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4cesNFWIntegrase/1.000
4cjuJNSIntegrase/0.650
4ceoG0TIntegrase/0.634
4cerVL4Integrase/0.632
4cghLOZIntegrase/0.632
4cf23GMIntegrase/0.630
4ceqQCHIntegrase/0.626
4cec2SSIntegrase/0.621
4cefD0TIntegrase/0.619
4cj3E4FIntegrase/0.618
4cf8V7HIntegrase/0.617
4cjfRVNIntegrase/0.617
4cgjNZLIntegrase/0.614
4ceaZSWIntegrase/0.608
3zswZSWIntegrase/0.604
4cgd8P3Integrase/0.601
3zsvZSVIntegrase/0.600
4cebZSVIntegrase/0.600
4cf0O5UIntegrase/0.594
4cfaWOPIntegrase/0.591
4cfdS8YIntegrase/0.589
4cigX0PIntegrase/0.587
4ce9O3NIntegrase/0.586
4cgiNZLIntegrase/0.586
4cifJDXIntegrase/0.586
4ck1OM1Integrase/0.585
3zt0ZT0Integrase/0.580
4cjrFYMIntegrase/0.580
4cjkH39Integrase/0.579
4cjeQ31Integrase/0.575
4ceeB0TIntegrase/0.573
4ck2NVUIntegrase/0.573
4cjqVXOIntegrase/0.572
3zsyOM3Integrase/0.569
4ck3K1TIntegrase/0.568
3zszOM2Integrase/0.567
4cieY7NIntegrase/0.567
3zsrO3NIntegrase/0.566
4cezO3NIntegrase/0.566
3zt3ZT4Integrase/0.563
4cf1IY7Integrase/0.560
3zsxN44Integrase/0.559
4ced9NSIntegrase/0.559
3zsqO4NIntegrase/0.556
4cjp4D2Integrase/0.556
4cfbOM3Integrase/0.550
3zt1OM1Integrase/0.549
4chyC5QIntegrase/0.549
4cj54VWIntegrase/0.549
3zt2ZT2Integrase/0.545
4cfc7NVIntegrase/0.540
4cjsL0YIntegrase/0.539
3zcmPX3Integrase/0.534
4cggK5QIntegrase/0.532
4cj4S3GIntegrase/0.528
4chqCWUIntegrase/0.519
4d03FADPhenylacetone monooxygenase1.14.13.920.496
5iu4ZMAAdenosine receptor A2a/0.493
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.491
1uxjNADMalate dehydrogenase/0.490
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.488
4jx1CAHCamphor 5-monooxygenase1.14.15.10.486
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.485
3kb1ADPIron-sulfur cluster carrier protein/0.484
4y8wSTRSteroid 21-hydroxylase/0.484
1di8DTQCyclin-dependent kinase 22.7.11.220.483
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.483
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.482
3sw418KCyclin-dependent kinase 22.7.11.220.480
3emlZMAAdenosine receptor A2a/0.480
3qlrNDPDihydrofolate reductase1.5.1.30.479
1e9hINRCyclin-dependent kinase 22.7.11.220.478
2vttLZDCyclin-dependent kinase 22.7.11.220.478
4a81DXCMajor pollen allergen Bet v 1-A/0.478
4ez30S0Cyclin-dependent kinase 22.7.11.220.478
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.478
5eccNAPDehydrofolate reductase type I/0.478
1ia1NDPDihydrofolate reductase1.5.1.30.477
1m78NDPDihydrofolate reductase1.5.1.30.477
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.477
2zb3NDPProstaglandin reductase 21.3.1.480.476
3sw719KCyclin-dependent kinase 22.7.11.220.476
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.476
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.475
3pe2E1BCasein kinase II subunit alpha2.7.11.10.475
1fmlRTLRetinol dehydratase/0.474
2yaaATPDeath-associated protein kinase 2/0.474
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.474
3pxyJWSCyclin-dependent kinase 22.7.11.220.474
1ma0NADAlcohol dehydrogenase class-31.1.1.10.473
2npxNADNADH peroxidase1.11.1.10.473
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.473
4kip1R9Mitogen-activated protein kinase 14/0.473
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.472
2xrwANPMitogen-activated protein kinase 82.7.11.240.472
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
3bv3P39Mitogen-activated protein kinase 14/0.472
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.472
3oibFDAPutative acyl-CoA dehydrogenase/0.471
3q43D66M1 family aminopeptidase3.4.110.471
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.470
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.470
3qu0X40Cyclin-dependent kinase 22.7.11.220.470
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.470
4jl5ADPAdenylate kinase/0.470
5iua6DXAdenosine receptor A2a/0.470
1xs7MMIBeta-secretase 13.4.23.460.469
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2cbrA80Cellular retinoic acid-binding protein 1/0.469
4fv7E94Mitogen-activated protein kinase 12.7.11.240.469
4jkyADPAdenylate kinase/0.469
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
2cchATPCyclin-dependent kinase 22.7.11.220.468
3qziX72Cyclin-dependent kinase 22.7.11.220.468
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.468
4e8wIHAD-beta-D-heptose 7-phosphate kinase/0.468
4fko20KCyclin-dependent kinase 22.7.11.220.468
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.468
2ahrNAPPyrroline-5-carboxylate reductase/0.467
3g51ANPRibosomal protein S6 kinase alpha-32.7.11.10.467
3mvm39PMitogen-activated protein kinase 14/0.467
4pd6URINucleoside permease/0.467
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.466
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.466
2ylzFADPhenylacetone monooxygenase1.14.13.920.466
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.466
4ure1PSCyclohexanol dehydrogenase/0.466
5idwNAPShort-chain dehydrogenase/reductase SDR/0.466
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.465
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.464
1x2hLPALipoate-protein ligase A6.3.1.200.464
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
4djaFAD(6-4) photolyase/0.464
4tvbNADHomospermidine synthase2.5.1.440.464
5iu86DZAdenosine receptor A2a/0.464
1obnASVIsopenicillin N synthase1.21.3.10.463
1qorNDPQuinone oxidoreductase 1/0.463
2a94AP0L-lactate dehydrogenase1.1.1.270.463
2x7hPFNProstaglandin reductase 310.463
3q44D50M1 family aminopeptidase3.4.110.463
3vs3VSETyrosine-protein kinase HCK2.7.10.20.463
3zdu38RCyclin-dependent kinase-like 32.7.11.220.463
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.463
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.463
1ve3SAMUncharacterized protein/0.462
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.462
2w3bNDPDihydrofolate reductase1.5.1.30.462
3gw9VNILanosterol 14-alpha-demethylase/0.462
4eiyZMAAdenosine receptor A2a/0.462
4l0qNADAlcohol dehydrogenase class-3/0.462
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
1eioGCHGastrotropin/0.461
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3d84NDPDihydrofolate reductase1.5.1.30.461
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
4a83DXCMajor pollen allergen Bet v 1-A/0.461
4an4DUDPutative glycosyl transferase/0.461
1bygSTUTyrosine-protein kinase CSK/0.460
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.460
2ylxFADPhenylacetone monooxygenase1.14.13.920.460
3k4nFADPyranose 2-oxidase/0.460
4i6gFADCryptochrome-2/0.460
4l5b1UXDeoxycytidine kinase2.7.1.740.460
4tuvCPZCytochrome P450 1191.140.460
4xumIMNPeroxisome proliferator-activated receptor gamma/0.460
5f8eSAHPossible transcriptional regulatory protein/0.460
5fl3ADPPili retraction protein PilT/0.460
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.459
1xddAAYIntegrin alpha-L/0.459
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.459
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.459
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.459
3iaeD7KBenzaldehyde lyase/0.459
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3tucFPWTyrosine-protein kinase SYK2.7.10.20.459
3zh8C58Protein kinase C iota type2.7.11.130.459
4k9dNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.459
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.458
2c29NAPDihydroflavonol 4-reductase/0.458
2ft0ACOdTDP-fucosamine acetyltransferase/0.458
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.458
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.458
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.458
3r354CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.458
3vjoANPEpidermal growth factor receptor2.7.10.10.458
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.458
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.458
4em9TCEPeroxisome proliferator-activated receptor gamma/0.458
4la0198Serum albumin/0.458
4rquNADAlcohol dehydrogenase class-P/0.458
5iubCLRAdenosine receptor A2a/0.458
5k2dZMAAdenosine receptor A2a/0.458
1b2lNDCAlcohol dehydrogenase1.1.1.10.457
1ur5NADMalate dehydrogenase/0.457
1xe65FPPlasmepsin-23.4.23.390.457
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.457
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.457
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.457
2ym2FADPhenylacetone monooxygenase1.14.13.920.457
3ft5MO8Heat shock protein HSP 90-alpha/0.457
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.457
3mdmFJZCholesterol 24-hydroxylase/0.457
3qlsNDPDihydrofolate reductase1.5.1.30.457
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.457
4q71FADBifunctional protein PutA/0.457
1mp0NADAlcohol dehydrogenase class-31.1.1.10.456
1xe55FEPlasmepsin-23.4.23.390.456
2gtnLIEMitogen-activated protein kinase 14/0.456
2i5bADPPyridoxine kinase/0.456
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.456
2znq401Peroxisome proliferator-activated receptor delta/0.456
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.456
3ixp834Ecdysone receptor/0.456
3slkNDPPolyketide synthase extender module 2/0.456
3w32W32Epidermal growth factor receptor2.7.10.10.456
4dymIYZActivin receptor type-12.7.11.300.456
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.456
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.456
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.456
5k2bZMAAdenosine receptor A2a/0.456
1b16NAQAlcohol dehydrogenase1.1.1.10.455
1ef92CPMethylmalonyl-CoA decarboxylase4.1.1.410.455
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.455
1osvCHCBile acid receptor/0.455
1u4oNDDL-lactate dehydrogenase1.1.1.270.455
2bsmBSMHeat shock protein HSP 90-alpha/0.455
2d29FADAcyl-CoA dehydrogenase/0.455
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.455
2rh9IGPTryptophan synthase alpha chain/0.455
3aosJH2Hemolymph juvenile hormone binding protein/0.455
3h3t16HCollagen type IV alpha-3-binding protein/0.455
3ijdC2FMethylenetetrahydrofolate reductase/0.455
3lqfNADGalactitol dehydrogenase/0.455
3rbvNAPSugar 3-ketoreductase/0.455
3triNAPPyrroline-5-carboxylate reductase/0.455
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.455
4hxyNDPPlm1/0.455
4jloADPAdenylate kinase/0.455
4nieNBHNuclear receptor ROR-gamma/0.455
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.455
1b15NAEAlcohol dehydrogenase1.1.1.10.454
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.454
2hog710Serine/threonine-protein kinase Chk12.7.11.10.454
2j5xGSPADP-ribosylation factor 6/0.454
2o7pNAPRiboflavin biosynthesis protein RibD/0.454
2po7CHDFerrochelatase, mitochondrial4.99.1.10.454
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.454
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.454
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3fklFKLMitogen-activated protein kinase 14/0.454
3nww3NWMitogen-activated protein kinase 14/0.454
3qxpX64Cyclin-dependent kinase 22.7.11.220.454
3sls77DDual specificity mitogen-activated protein kinase kinase 12.7.12.20.454
3vt5YI2Vitamin D3 receptor/0.454
4aotGW8Serine/threonine-protein kinase 102.7.11.10.454
4cukNAID-lactate dehydrogenase/0.454
4fki09KCyclin-dependent kinase 22.7.11.220.454
4fkr45KCyclin-dependent kinase 22.7.11.220.454
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.454
4kgmATPUncharacterized protein/0.454
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.454
1jpaANPEphrin type-B receptor 22.7.10.10.453
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.453
1q3ePCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.453
1rj6AZMCarbonic anhydrase 144.2.1.10.453
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.453
1sxjADPReplication factor C subunit 5/0.453
1tehNADAlcohol dehydrogenase class-31.1.1.10.453
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.453
2ii5CO6Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial2.3.1.1680.453
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.453
3mt817TGlycogen phosphorylase, muscle form2.4.1.10.453
3p3e3P3UDP-3-O-acyl-N-acetylglucosamine deacetylase/0.453
3qtxX43Cyclin-dependent kinase 22.7.11.220.453
3r9nZ68Cyclin-dependent kinase 22.7.11.220.453
4ap1NAPSteroid monooxygenase/0.453
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.453
4fv0EK3Mitogen-activated protein kinase 12.7.11.240.453
4m10ICDProstaglandin G/H synthase 21.14.99.10.453
4nfsNAJAlcohol dehydrogenase E chain1.1.1.10.453
4yp7NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.453
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.453
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.452
1h74AGSHomoserine kinase2.7.1.390.452
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
1powFADPyruvate oxidase1.2.3.30.452
1urwI1PCyclin-dependent kinase 22.7.11.220.452
1x8lOXRRetinol dehydratase/0.452
2w9hTOPDihydrofolate reductase1.5.1.30.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
3a14NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase/0.452
3bi2FADPolyamine oxidase FMS1/0.452
3gvhNADMalate dehydrogenase/0.452
3pqbVGPPutative oxidoreductase/0.452
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.452
4gl4NAIAlcohol dehydrogenase class-3/0.452
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.452
4l4xNDPAmphI/0.452
4xq9NADHomospermidine synthase2.5.1.440.452
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.451
2q9fC3SCholesterol 24-hydroxylase/0.451
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.451
3b6zCO7Enoyl reductase LovC10.451
3gbuATPUncharacterized sugar kinase PH14592.7.10.451
3iphG11Mitogen-activated protein kinase 14/0.451
3mg3ECHOrange carotenoid-binding protein/0.451
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.451
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.451
4ambDUDPutative glycosyl transferase/0.451
4bftZVTPantothenate kinase2.7.1.330.451
4du82P0Mevalonate diphosphate decarboxylase/0.451
4g1z0VPVitamin D3 receptor A/0.451
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.451
2gyoCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.450
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.450
2q6sPLBPeroxisome proliferator-activated receptor gamma/0.450
2rqfJH3Hemolymph juvenile hormone binding protein/0.450
3c14FOKAdenylate cyclase type 2/0.450
3c14FOKAdenylate cyclase type 5/0.450
3fskRO6Mitogen-activated protein kinase 14/0.450
3iok1P6Tyrosine-protein kinase JAK2/0.450
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3rk507ZCyclin-dependent kinase 22.7.11.220.450
3vt9YI4Vitamin D3 receptor/0.450
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.450
4eji0QACytochrome P450 2A131.14.14.10.450
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.450
4ng2OHNTranscriptional activator protein LasR/0.450
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.449
1pzhNADLactate dehydrogenase/0.449
1y0s331Peroxisome proliferator-activated receptor delta/0.449
2acxANPG protein-coupled receptor kinase 62.7.11.160.449
2np8CC3Aurora kinase A2.7.11.10.449
2nq8ZIDEnoyl-ACP reductase/0.449
2y6o1N1Ephrin type-A receptor 42.7.10.10.449
2ya3J7V5'-AMP-activated protein kinase subunit gamma-1/0.449
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.449
3aw9NADNAD-dependent epimerase/dehydratase/0.449
3bg7FADPyranose 2-oxidase/0.449
3flwFLWMitogen-activated protein kinase 14/0.449
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.449
3juhANPCasein kinase II subunit alpha2.7.11.10.449
3jynNDPQuinone oxidoreductase/0.449
3lkiATPFructokinase/0.449
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.449
4acm7YGCyclin-dependent kinase 22.7.11.220.449
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.449
4boeCLRJapanin/0.449
4ly91YYGlucokinase regulatory protein/0.449
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.449
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.449
4y93746Tyrosine-protein kinase/0.449
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.449
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.449
1bwsNDPGDP-L-fucose synthase/0.448
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
1p8dCO1Oxysterols receptor LXR-beta/0.448
1txtCAAHMG-CoA synthase/0.448
2bfyH1NAurora kinase B-A2.7.11.10.448
2bx8AZQSerum albumin/0.448
2d4eNAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831]/0.448
2gtmLIDMitogen-activated protein kinase 14/0.448
2vnhFADNADPH:ferredoxin reductase/0.448
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
2yxuATPPyridoxal kinase2.7.1.350.448
2zevB71Geranylgeranyl pyrophosphate synthase/0.448
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.448
3efwAK8Aurora kinase A2.7.11.10.448
3gwfFADCyclohexanone monooxygenase/0.448
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.448
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.448
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
3zxsFADDeoxyribodipyrimidine photolyase-related protein/0.448
4ead0NPThymidine phosphorylase2.4.2.40.448
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.448
4jldADPAdenylate kinase/0.448
4k6fNAPPutative Acetoacetyl-CoA reductase/0.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1drhNAPDihydrofolate reductase1.5.1.30.447
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.447
1scuCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.447
1tysTMPThymidylate synthase/0.447
2d52COA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.447
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3eljGS7Mitogen-activated protein kinase 82.7.11.240.447
3gfzFMNUncharacterized protein/0.447
3nxxNDPDihydrofolate reductase1.5.1.30.447
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.447
3qwbNDPProbable quinone oxidoreductase1.6.5.50.447
3stv3HOMethylketone synthase I/0.447
3toh079Gag-Pol polyprotein2.7.7.490.447
4ap1FADSteroid monooxygenase/0.447
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.447
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.447
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.447
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.447
4m4922YL-lactate dehydrogenase A chain1.1.1.270.447
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.447
4yerADPAntibiotic ABC transporter, ATP-binding protein, putative/0.447
1bdlIM1Gag-Pol polyprotein3.4.23.160.446
1kkq471Peroxisome proliferator-activated receptor alpha/0.446
1ozhHE3Acetolactate synthase, catabolic2.2.1.60.446
1ppjANYCytochrome b/0.446
1sowNADL-lactate dehydrogenase1.1.1.270.446
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.446
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
2eklNADD-3-phosphoglycerate dehydrogenase/0.446
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.446
2w1hL0FCyclin-dependent kinase 22.7.11.220.446
2w2lNADD-mandelate dehydrogenase/0.446
2xaaNADSecondary alcohol dehydrogenase/0.446
2xvw9NRSerum albumin/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
2zrjAGSProtein RecA/0.446
3akn11DFatty acid-binding protein, intestinal/0.446
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3p7nFMNLight-activated DNA-binding protein EL222/0.446
3rak03ZCyclin-dependent kinase 22.7.11.220.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
3u33FADPutative acyl-CoA dehydrogenase AidB1.3.990.446
3unj0BXCyclin-dependent kinase 22.7.11.220.446
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.446
4aa4QC0Mitogen-activated protein kinase 14/0.446
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4c62XWWTyrosine-protein kinase JAK2/0.446
4hjoAQ4Epidermal growth factor receptor2.7.10.10.446
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4loqSB4Mitogen-activated protein kinase 14/0.446
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.446
1dr2TAPDihydrofolate reductase1.5.1.30.445
1dr3TAPDihydrofolate reductase1.5.1.30.445
1hbvGANGag-Pol polyprotein/0.445
1jtuLYBThymidylate synthase/0.445
1pnvTYDdTDP-epi-vancosaminyltransferase2.4.1.3110.445
1w0xOLOCyclin-dependent kinase 22.7.11.220.445
1ykdCMPAdenylate cyclase/0.445
1z6tADPApoptotic protease-activating factor 1/0.445
1zdwFLVPrenyltransferase/0.445
1zys199Serine/threonine-protein kinase Chk12.7.11.10.445
2ahvCOAAcetate CoA-transferase YdiF2.8.3.80.445
2b7aIZATyrosine-protein kinase JAK2/0.445
2oapANPType II secretion system protein (GspE-2)/0.445
2w17I19Cyclin-dependent kinase 22.7.11.220.445
2xa4AZ5Tyrosine-protein kinase JAK2/0.445
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.445
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.445
3i59N6RCRP-like cAMP-activated global transcriptional regulator/0.445
3i60E86Mitogen-activated protein kinase 12.7.11.240.445
3il1B5DGlutamate receptor 2/0.445
3le62BZCyclin-dependent kinase 22.7.11.220.445
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
3unk0BYCyclin-dependent kinase 22.7.11.220.445
3w0hW12Vitamin D3 receptor/0.445
3w0jT08Vitamin D3 receptor/0.445
3zoiM2WIsopenicillin N synthase1.21.3.10.445
4a8v2ANMajor pollen allergen Bet v 1-J/0.445
4cgfUJ6Integrase/0.445
4e8yIHAD-beta-D-heptose 7-phosphate kinase/0.445
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.445
4nmbFADBifunctional protein PutA/0.445
4pztSOPHistone acetyltransferase p300/0.445
5e8ySTUTGF-beta receptor type-22.7.11.300.445
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.444
1ai9NDPDihydrofolate reductase1.5.1.30.444
1crbRTLRetinol-binding protein 1/0.444
1ie8KH1Vitamin D3 receptor/0.444
1lwlDSOCamphor 5-monooxygenase1.14.15.10.444
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.444
1r6g442Thyroid hormone receptor beta/0.444
1rrmAPRLactaldehyde reductase1.1.1.770.444
1u54ACPActivated CDC42 kinase 1/0.444
2bbwGP5Adenylate kinase 4, mitochondrial/0.444
2bheBRYCyclin-dependent kinase 22.7.11.220.444
2d3mCOA5,7-dihydroxy-2-methylchromone synthase2.3.1.2160.444
2fhnBNIAvidin-related protein 4/5/0.444
2pdtFADVivid PAS protein VVD/0.444
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.444
2uv0OHNTranscriptional activator protein LasR/0.444
2vnkFADNADPH:ferredoxin reductase/0.444
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.444
2x9dITCTetracycline repressor protein class D/0.444
2xnbY8LCyclin-dependent kinase 22.7.11.220.444
2xw7NDPDihydrofolate reductase/0.444
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.444
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.444
3jpuTY4Transcriptional activator protein LasR/0.444
3py0SU9Cyclin-dependent kinase 22.7.11.220.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
3rkb12ZCyclin-dependent kinase 22.7.11.220.444
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.444
3vrwYS5Vitamin D3 receptor/0.444
3vt7VDXVitamin D3 receptor/0.444
4dc0NDPPutative ketoacyl reductase1.3.10.444
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.444
4fkzUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
4kfp1R7Nicotinamide phosphoribosyltransferase2.4.2.120.444
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.444
4oztP1AEcdysone receptor, putative/0.444
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
1fmjRTLRetinol dehydratase/0.443
1jq5NADGlycerol dehydrogenase1.1.1.60.443
1me6IVSPlasmepsin-23.4.23.390.443
1n9lFMNPutative blue light receptor/0.443
1nq14HYThyroid hormone receptor beta/0.443
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.443
1v9aSAHUncharacterized protein/0.443
1yqdNAPSinapyl alcohol dehydrogenase/0.443
2bi4NADLactaldehyde reductase1.1.1.770.443
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.443
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.443
2iko7IGRenin3.4.23.150.443
2ojg19AMitogen-activated protein kinase 12.7.11.240.443
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.443
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3flzFLZMitogen-activated protein kinase 14/0.443
3gdpFAD(R)-mandelonitrile lyase 24.1.2.100.443
3ha5SFGHydroxymycolate synthase MmaA42.1.10.443
3hx4ANPCalmodulin-domain protein kinase 1/0.443
3lkhLT6Genome polyprotein2.7.7.480.443
3rj5NADAlcohol dehydrogenase1.1.1.10.443
3rk909ZCyclin-dependent kinase 22.7.11.220.443
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.443
3w0gW07Vitamin D3 receptor/0.443
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.443
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4awo99BHeat shock protein HSP 90-alpha/0.443
4bj8BTNAvidin/0.443
4ixfIXFDihydrofolate reductase1.5.1.30.443
4mv8ACPBiotin carboxylase6.3.4.140.443
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.443
4qi7FADCellobiose dehydrogenase/0.443
4z24FADPutative GMC-type oxidoreductase R13510.443
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.443
5fm7ADPRuvB-like helicase/0.443
1gd1NADGlyceraldehyde-3-phosphate dehydrogenase/0.442
1hb1OCVIsopenicillin N synthase1.21.3.10.442
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.442
1kqgHQOFormate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit/0.442
1kqwRTLCellular retinol-binding protein type II/0.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.442
2igoFADPyranose 2-oxidase/0.442
2pvyACPFibroblast growth factor receptor 2/0.442
2q70DC8Estrogen receptor/0.442
2rcyNAPPyrroline-5-carboxylate reductase/0.442
2vn0TDZCytochrome P450 2C8/0.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.442
2yylFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.442
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.442
3fr8NDPKetol-acid reductoisomerase, chloroplastic1.1.1.860.442
3imeBZ2Pantothenate synthetase6.3.2.10.442
3lfsA07Cyclin-dependent kinase 22.7.11.220.442
3p62FMNPentaerythritol tetranitrate reductase/0.442
3t3r9PLCytochrome P450 2A61.14.130.442
3t8oATPRhodopsin kinase/0.442
3zk5Z18Cytochrome P450 monooxygenase PikC/0.442
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.442
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.442
4b1rITCTetracycline repressor protein class D/0.442
4b8wNAPGDP-L-fucose synthase1.1.1.2710.442
4dptAGSMevalonate diphosphate decarboxylase/0.442
4fod0UVALK tyrosine kinase receptor2.7.10.10.442
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.442
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.442
4fxfATPPyruvate kinase PKM2.7.1.400.442
4ia3BIVVitamin D3 receptor A/0.442
4k5o1OTM1 family aminopeptidase3.4.110.442
4ki8ADP60 kDa chaperonin/0.442
4mlp2CXCryptochrome-2/0.442
4s1hADPPyridoxal kinase, putative/0.442
4y95746Tyrosine-protein kinase/0.442
5dr2ATPAurora kinase A2.7.11.10.442
5e8wSTUTGF-beta receptor type-12.7.11.300.442
5kf1ACOPredicted acetyltransferase/0.442
1h51FMNPentaerythritol tetranitrate reductase/0.441
1n5dNDPCarbonyl reductase [NADPH] 1/0.441
1phePIYCamphor 5-monooxygenase1.14.15.10.441
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
1tj0FADBifunctional protein PutA1.5.5.20.441
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.441
1wwkNAD307aa long hypothetical phosphoglycerate dehydrogenase/0.441
1z1fSTLResveratrol synthase/0.441
1zrzBI1Protein kinase C iota type2.7.11.130.441
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.441
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.441
2g1y5IGRenin3.4.23.150.441
2hcdBIVVitamin D3 receptor A/0.441
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.441
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.441
2pmoHMDProtein kinase 7/0.441
2tctCTCTetracycline repressor protein class D/0.441
2vbdV10Isopenicillin N synthase1.21.3.10.441
2ylsFADPhenylacetone monooxygenase1.14.13.920.441
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.441
3ec0GRLGag-Pol polyprotein3.4.23.470.441
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3kvxFMYMitogen-activated protein kinase 102.7.11.240.441
3lsiFADPyranose 2-oxidase/0.441
3otfCMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.441
3q3cNADNAD-dependent L-serine dehydrogenase/0.441
3r7eX88Cyclin-dependent kinase 22.7.11.220.441
3r7uX96Cyclin-dependent kinase 22.7.11.220.441
3sheI85MAP kinase-activated protein kinase 32.7.11.10.441
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.441
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
4ejmNAPPutative zinc-binding dehydrogenase/0.441
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.441
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4i6aHMG3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.880.441
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.441
4kxn6K62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.441
4o671SYCyclic GMP-AMP synthase/0.441
4u03GTPCyclic GMP-AMP synthase/0.441
4wecNADShort chain dehydrogenase/0.441
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.441
5dp2NAPCurF/0.441
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.441
5il1SAMN6-adenosine-methyltransferase 70 kDa subunit/0.441
5kczNAJAlcohol dehydrogenase E chain1.1.1.10.441
1e7aPFLSerum albumin/0.440
1f0xFADD-lactate dehydrogenase1.1.1.280.440
1fdtESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1h1s4SPCyclin-dependent kinase 22.7.11.220.440
2bxmIMNSerum albumin/0.440
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2hr8SAHDiphthine synthase/0.440
2ituITQEpidermal growth factor receptor2.7.10.10.440
2o12FMNChorismate synthase/0.440
2om9AJAPeroxisome proliferator-activated receptor gamma/0.440
2oz6CMPCyclic AMP receptor-like protein/0.440
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.440
2qoqANPEphrin type-A receptor 32.7.10.10.440
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.440
2xmyCDKCyclin-dependent kinase 22.7.11.220.440
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.440
2ydwWSHBromodomain-containing protein 2/0.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
2zjwREFCasein kinase II subunit alpha2.7.11.10.440
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.440
3cvuFADRE11660p/0.440
3dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
3dl0AP5Adenylate kinase/0.440
3g8eIS1Nicotinamide phosphoribosyltransferase2.4.2.120.440
3oom507Activin receptor type-12.7.11.300.440
3ormAGSSerine/threonine protein kinase/0.440
3oy4017Gag-Pol polyprotein3.4.23.160.440
3q8xUD1Toxin zeta/0.440
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.440
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.440
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
3vwdACOAlpha-tubulin N-acetyltransferase 1/0.440
3zewSTUEphrin type-B receptor 42.7.10.10.440
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.440
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.440
4fkw62KCyclin-dependent kinase 22.7.11.220.440
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4i22IREEpidermal growth factor receptor2.7.10.10.440
4kin1M8Mitogen-activated protein kinase 14/0.440
4mihFADPyranose 2-oxidase1.1.3.100.440
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.440
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
4plpNADHomospermidine synthase2.5.1.440.440
4qi5FADCellobiose dehydrogenase/0.440
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.440
4y8vADPAcyl-CoA synthetase (NDP forming)/0.440
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440
4zowCLMMultidrug transporter MdfA/0.440
5f0a1FBcGMP-dependent protein kinase, putative/0.440