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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ccrFADThioredoxin reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ccrFADThioredoxin reductase/1.000
4ccqFADThioredoxin reductase/0.544
4cbqFADThioredoxin reductase/0.526
3itjFADThioredoxin reductase 11.8.1.90.522
4up3FADThioredoxin reductase/0.519
4a5lFADThioredoxin reductase/0.512
3ishFADThioredoxin reductase1.8.1.90.491
1tdeFADThioredoxin reductase1.8.1.90.490
1cl0FADThioredoxin reductase1.8.1.90.473
3f8dFADNADH oxidase/thioredoxin reductase/0.471
4jnqFDAThioredoxin reductase/0.464
4ykfFADAlkyl hydroperoxide reductase subunit F1.8.10.455
1trbFADThioredoxin reductase1.8.1.90.452
4o5qFADAlkyl hydroperoxide reductase subunit F1.8.10.450
1tdfFADThioredoxin reductase1.8.1.90.448
2q0kFADThioredoxin reductase1.8.1.90.446
1fl2FADAlkyl hydroperoxide reductase subunit F1.8.10.443
4gcmFADThioredoxin reductase1.8.1.90.443