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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4cbxATPActin-2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4cbxATPActin-2/1.000
3mn9ATPActin-5C/0.595
3mn6ATPActin-5C/0.594
1qz5ATPActin, alpha skeletal muscle/0.556
1s22ATPActin, alpha skeletal muscle/0.534
2q36ATPActin, alpha skeletal muscle/0.533
4m63ATPActin-5C/0.528
1lotATPActin, alpha skeletal muscle/0.526
5ce3ATPActin/0.523
1h1vATPActin, alpha skeletal muscle/0.521
4pkgATPActin, alpha skeletal muscle/0.516
3el2ATPActin-5C/0.515
3mn7ATPActin-5C/0.513
1t44ATPActin, alpha skeletal muscle/0.510
4k42ADPActin, alpha skeletal muscle/0.508
3tu5ATPActin, alpha skeletal muscle/0.507
1rgiATPActin, alpha skeletal muscle/0.505
1c0fATPMajor actin/0.501
1nmdATPMajor actin/0.500
1nm1ATPMajor actin/0.497
3ffkATPActin, alpha skeletal muscle/0.496
4pkhADPActin, alpha skeletal muscle/0.492
3a5mATPMajor actin/0.491
3u9dATPActin, alpha skeletal muscle/0.488
3m6gATPActin, alpha skeletal muscle/0.487
4jhdANPActin-5C/0.487
4ci6ATPActin/0.485
3m1fATPActin, alpha skeletal muscle/0.484
1eqyATPActin, alpha skeletal muscle/0.482
1kxpATPActin, alpha skeletal muscle/0.476
4k41ATPActin, alpha skeletal muscle/0.476
4pl8ATPActin, alpha skeletal muscle/0.476
2p9kATPActin-related protein 2/0.475
1ijjATPActin, alpha skeletal muscle/0.470
1mduATPActin, alpha skeletal muscle/0.470
4rwtANPActin-5C/0.469
2v51ATPActin, alpha skeletal muscle/0.467
3eksATPActin-5C/0.466
1yxqATPActin, alpha skeletal muscle/0.464
2oanATPActin, cytoplasmic 1/0.463
3u4lATPActin, cytoplasmic 1/0.459
4pkiATPActin, alpha skeletal muscle/0.458
1dejATPMajor actin/0.444