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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c9wVGH7,8-dihydro-8-oxoguanine triphosphatase3.6.1.55

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c9wVGH7,8-dihydro-8-oxoguanine triphosphatase3.6.1.551.000
5ansRX87,8-dihydro-8-oxoguanine triphosphatase3.6.1.550.526
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.484
2y37A54Nitric oxide synthase, inducible1.14.13.390.472
3gwfNAPCyclohexanone monooxygenase/0.470
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.468
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.467
2po7CHDFerrochelatase, mitochondrial4.99.1.10.465
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.465
3uftHW7Nitric oxide synthase, brain1.14.13.390.462
3hl0NADMaleylacetate reductase/0.461
4a81DXCMajor pollen allergen Bet v 1-A/0.461
3ebf332Nitric oxide synthase, inducible1.14.13.390.458
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.458
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.457
3n62XFJNitric oxide synthase, brain1.14.13.390.456
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.455
3oafOAGDihydrofolate reductase1.5.1.30.455
4ug71EVNitric oxide synthase oxygenase1.14.13.1650.455
1pqc444Oxysterols receptor LXR-beta/0.454
4iarERM5-hydroxytryptamine receptor 1B/0.453
1bzfTMQDihydrofolate reductase1.5.1.30.451
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.451
1eioGCHGastrotropin/0.450
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.450
4uymVOR14-alpha sterol demethylase Cyp51B/0.450
1qw514WNitric oxide synthase, inducible1.14.13.390.449
3b9lAZZSerum albumin/0.448
1dr3HBIDihydrofolate reductase1.5.1.30.446
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1fmlRTLRetinol dehydratase/0.445
1m13HYFNuclear receptor subfamily 1 group I member 2/0.445
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.445
3p3zP3ZPutative cytochrome P450/0.445
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4klaCHDFerrochelatase, mitochondrial4.99.1.10.445
1pkfEPDEpothilone C/D epoxidase1.140.444
2ipjFFAAldo-keto reductase family 1 member C2/0.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
3n5xXFKNitric oxide synthase, brain1.14.13.390.444
4kbyC2EStimulator of interferon genes protein/0.444
2jn3JN3Fatty acid-binding protein, liver/0.443
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3zoiM2WIsopenicillin N synthase1.21.3.10.443
4dc0NDPPutative ketoacyl reductase1.3.10.443
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4a83DXCMajor pollen allergen Bet v 1-A/0.442
4cx5HW8Nitric oxide synthase, brain1.14.13.390.442
4jseQJ2Nitric oxide synthase, brain1.14.13.390.442
4l1xSTRAldo-keto reductase family 1 member C2/0.442
4xo7ASDAldo-keto reductase family 1 member C2/0.442
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3nlw3XFNitric oxide synthase, brain1.14.13.390.441
4r20AERCytochrome P450 family 17 polypeptide 2/0.441
1lkdBP6Biphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
2g1o2IGRenin3.4.23.150.440
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3rqkX2CNitric oxide synthase, brain1.14.13.390.440
4jsfQJ4Nitric oxide synthase, brain1.14.13.390.440
4lwbQJ8Nitric oxide synthase oxygenase1.14.13.1650.440