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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.11.000
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.569
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.555
4o2z046Mitogen-activated protein kinase/0.542
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.539
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.534
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.530
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.512
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.509
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.493
2og81N8Tyrosine-protein kinase Lck2.7.10.20.489
2hyySTITyrosine-protein kinase ABL12.7.10.20.484
4aa0AA0Mitogen-activated protein kinase 14/0.482
3efl706Vascular endothelial growth factor receptor 22.7.10.10.475
4ksp1SUSerine/threonine-protein kinase B-raf2.7.11.10.465
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.465
3hng8STVascular endothelial growth factor receptor 12.7.10.10.464
4eyjN61Mitogen-activated protein kinase 132.7.11.240.464
1iepSTITyrosine-protein kinase ABL12.7.10.20.462
3hv5R24Mitogen-activated protein kinase 14/0.459
3kq7KQ7Mitogen-activated protein kinase 14/0.452
3eta351Insulin receptor2.7.10.10.450
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.448
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.441
4kaoKAOFocal adhesion kinase 12.7.10.20.441