Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c72TLG3-oxoacyl-ACP synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c72TLG3-oxoacyl-ACP synthase/1.000
4c73TLH3-oxoacyl-ACP synthase/0.817
4c6zTLE3-oxoacyl-ACP synthase/0.735
2wggTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.620
4c717RD3-oxoacyl-ACP synthase/0.605
2aq7TL53-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.601
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.585
3g0yP9A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.574
2aqbTL63-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.571
3g11P9C3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.570
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.567
4jv3N32Beta-ketoacyl synthase/0.561
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.558
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.548
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.540
3hnzPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.540
4c6uTLG3-oxoacyl-ACP synthase/0.522
2iviACWIsopenicillin N synthase1.21.3.10.493
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.491
2wgeTLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.490
1bk0ACVIsopenicillin N synthase1.21.3.10.487
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.485
1culFOKAdenylate cyclase type 2/0.480
1culFOKAdenylate cyclase type 5/0.480
4bftZVTPantothenate kinase2.7.1.330.480
4bfxZVXPantothenate kinase2.7.1.330.478
5dozNDPJamJ/0.477
1lkeDOGBilin-binding protein/0.476
5dp2NAPCurF/0.475
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.473
3p3zP3ZPutative cytochrome P450/0.471
4e5pNADPhosphonate dehydrogenase1.20.1.10.471
5irnADPNucleotide binding oligomerization domain containing 2/0.471
3zkyWT4Isopenicillin N synthase1.21.3.10.470
4mlp2CXCryptochrome-2/0.470
1drhNAPDihydrofolate reductase1.5.1.30.469
2gv8NDPThiol-specific monooxygenase1.14.130.468
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.468
2zda32UProthrombin3.4.21.50.467
1rfgGMPPurine nucleoside phosphorylase2.4.2.10.466
2a9z26AAdenosine kinase2.7.1.200.466
2pksG44Prothrombin3.4.21.50.465
4bfvZVVPantothenate kinase2.7.1.330.465
4n3l2FNProthrombin3.4.21.50.465
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.464
1xddAAYIntegrin alpha-L/0.464
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.463
4bfsZVSPantothenate kinase2.7.1.330.463
4bfzZVZPantothenate kinase2.7.1.330.463
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.463
2zc922UProthrombin3.4.21.50.462
3nxvD2FDihydrofolate reductase1.5.1.30.462
3c35KAIGlutamate receptor ionotropic, kainate 1/0.461
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.461
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.461
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.460
2ivnANPtRNA N6-adenosine threonylcarbamoyltransferase/0.460
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.460
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.460
2zi224UProthrombin3.4.21.50.460
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.460
3ukuC69Actin-related protein 3/0.460
1qiqACCIsopenicillin N synthase1.21.3.10.459
1towCRZFatty acid-binding protein, adipocyte/0.459
2ab8MTPAdenosine kinase2.7.1.200.459
3v2uATPProtein GAL3/0.459
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.459
2ffqGSPRas-related protein Rab-6B/0.458
2x9dITCTetracycline repressor protein class D/0.458
2zhf49UProthrombin3.4.21.50.458
3fhxPXLPyridoxal kinase2.7.1.350.458
1c4uIH1Prothrombin3.4.21.50.457
1x1bSAHC-20 methyltransferase/0.457
2zgx29UProthrombin3.4.21.50.457
3d7kD7KBenzaldehyde lyase/0.457
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.457
3p8zSAHGenome polyprotein2.1.1.560.457
4bfwZVWPantothenate kinase2.7.1.330.457
1cjkFOKAdenylate cyclase type 2/0.456
1cjkFOKAdenylate cyclase type 5/0.456
2e07SAHDiphthine synthase/0.456
2jb4A14Isopenicillin N synthase1.21.3.10.456
3qwbNDPProbable quinone oxidoreductase1.6.5.50.456
4bfyZVYPantothenate kinase2.7.1.330.456
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.456
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.456
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.455
1xm1GAHProthrombin3.4.21.50.455
2a1oCAMCamphor 5-monooxygenase1.14.15.10.455
2a9y26AAdenosine kinase2.7.1.200.455
2x7hPFNProstaglandin reductase 310.455
3eksCY9Actin-5C/0.455
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.455
1d3dBZTProthrombin3.4.21.50.454
1h51FMNPentaerythritol tetranitrate reductase/0.454
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.454
1ta6177Prothrombin3.4.21.50.454
3c15FOKAdenylate cyclase type 2/0.454
3c15FOKAdenylate cyclase type 5/0.454
3qt62P0Mevalonate diphosphate decarboxylase/0.454
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
2w6qOA5Biotin carboxylase6.3.4.140.453
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.453
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3ojxFMNNADPH--cytochrome P450 reductase/0.453
4qaiFMNNADPH dehydrogenase/0.453
1cjtFOKAdenylate cyclase type 2/0.452
1cjtFOKAdenylate cyclase type 5/0.452
1qjfACSIsopenicillin N synthase1.21.3.10.452
2anmCDOProthrombin3.4.21.50.452
2x7tWZBCarbonic anhydrase 24.2.1.10.452
3ol5SAWCamphor 5-monooxygenase1.14.15.10.452
3qftFADNADPH--cytochrome P450 reductase/0.452
3uleC69Actin-related protein 3/0.452
3vyfVYFRenin3.4.23.150.452
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.452
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.451
1qoqIGPTryptophan synthase alpha chain/0.451
1z71L17Prothrombin3.4.21.50.451
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.451
2ggsNDPdTDP-4-dehydrorhamnose reductase/0.451
2owkSAHDiphthine synthase/0.451
2r2mI50Prothrombin3.4.21.50.451
2znk31UProthrombin3.4.21.50.451
3d4pNADL-lactate dehydrogenase 11.1.1.270.451
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.451
3mauEXTPutative sphingosine-1-phosphate lyase/0.451
4b63NAPL-ornithine N(5)-monooxygenase/0.451
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.451
1crbRTLRetinol-binding protein 1/0.450
1txtCAAHMG-CoA synthase/0.450
2ed3SAHDiphthine synthase/0.450
4dptAGSMevalonate diphosphate decarboxylase/0.450
1r2jFADFkbI/0.449
2bu9HFVIsopenicillin N synthase1.21.3.10.449
2ejzSAHDiphthine synthase/0.449
2hk9NAPShikimate dehydrogenase (NADP(+))/0.449
2uxpCLMHTH-type transcriptional regulator TtgR/0.449
2ym1FADPhenylacetone monooxygenase1.14.13.920.449
2zhq27UProthrombin3.4.21.50.449
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.449
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.449
4b4vL34Bifunctional protein FolD/0.449
4oviN01Phenylacetone monooxygenase1.14.13.920.449
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.449
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.448
2g1y5IGRenin3.4.23.150.448
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.448
2rlcCHDCholoylglycine hydrolase3.5.1.240.448
2z4zSC0Geranylgeranyl pyrophosphate synthase/0.448
3fhxPLPPyridoxal kinase2.7.1.350.448
4bb3KKAIsopenicillin N synthase1.21.3.10.448
5a0112VO-glycosyltransferase/0.448
1nm6L86Prothrombin3.4.21.50.447
2cv1ATPGlutamate--tRNA ligase6.1.1.170.447
2uuk897Prothrombin3.4.21.50.447
4djaFAD(6-4) photolyase/0.447
4jlm1NNDeoxycytidine kinase2.7.1.740.447
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.446
1oc1ASVIsopenicillin N synthase1.21.3.10.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
2v58LZJBiotin carboxylase6.3.4.140.446
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.446
2zbaZBATrichothecene 3-O-acetyltransferase/0.446
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.446
3h3r14HCollagen type IV alpha-3-binding protein/0.446
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.446
3p2oNADBifunctional protein FolD/0.446
1cjuFOKAdenylate cyclase type 2/0.445
1cjuFOKAdenylate cyclase type 5/0.445
1lluNADAlcohol dehydrogenase/0.445
1obnASVIsopenicillin N synthase1.21.3.10.445
1pqc444Oxysterols receptor LXR-beta/0.445
1sq5ADPPantothenate kinase2.7.1.330.445
1y0s331Peroxisome proliferator-activated receptor delta/0.445
1zrzBI1Protein kinase C iota type2.7.11.130.445
2eh5SAHDiphthine synthase/0.445
2uxoTACHTH-type transcriptional regulator TtgR/0.445
2v3oI26Prothrombin3.4.21.50.445
3dr8ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase/0.445
4b42942Glucose-1-phosphate thymidylyltransferase/0.445
4cdmFO1Deoxyribodipyrimidine photolyase/0.445
1mu6CDAProthrombin3.4.21.50.444
1ygjRMCPyridoxal kinase2.7.1.350.444
2bn4FMNNADPH--cytochrome P450 reductase/0.444
2whqHI6Acetylcholinesterase3.1.1.70.444
2xvhNAPPutative flavin-containing monooxygenase/0.444
2zdv37UProthrombin3.4.21.50.444
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3hk1B64Fatty acid-binding protein, adipocyte/0.444
3nx4NAPPutative oxidoreductase/0.444
4e5yNDPGDP-L-fucose synthase1.1.1.2710.444
4okx198Androgen receptor/0.444
1fmjRTLRetinol dehydratase/0.443
1j9zFADNADPH--cytochrome P450 reductase/0.443
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.443
1orrNADCDP-paratose 2-epimerase/0.443
2e94364Geranylgeranyl pyrophosphate synthase/0.443
2z3uCRRCytochrome P450/0.443
2zfr46UProthrombin3.4.21.50.443
3cneFMNPutative protease I/0.443
3d4bDZDNAD-dependent protein deacetylase/0.443
3phjDHKShikimate dehydrogenase (NADP(+))/0.443
4bfuZVUPantothenate kinase2.7.1.330.443
4eu8COASuccinyl-CoA:acetate CoA-transferase/0.443
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.443
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.443
1c7oPPGHemolysin/0.442
1eqaMG7Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase2.1.1.570.442
1hb3SCVIsopenicillin N synthase1.21.3.10.442
2cibCM6Lanosterol 14-alpha demethylase1.14.13.700.442
2dxiATPGlutamate--tRNA ligase6.1.1.170.442
2e8hSAHDiphthine synthase/0.442
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.442
2igoFADPyranose 2-oxidase/0.442
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.442
2pb6SAHDiphthine synthase/0.442
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.442
2zhe13UProthrombin3.4.21.50.442
3fcjFADNitroalkane oxidase1.7.3.10.442
3l6jZ90Alr2278 protein/0.442
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.442
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4gl4NAIAlcohol dehydrogenase class-3/0.442
4iah1DXAlr2278 protein/0.442
4rn615UProthrombin3.4.21.50.442
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
1pd9CO4Dihydrofolate reductase1.5.1.30.441
1qorNDPQuinone oxidoreductase 1/0.441
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.441
1ygkRRCPyridoxal kinase2.7.1.350.441
1z6tADPApoptotic protease-activating factor 1/0.441
2nr4FMNConserved protein/0.441
2ywlFADThioredoxin reductase related protein/0.441
2zsdCOAPantothenate kinase2.7.1.330.441
3gwfFADCyclohexanone monooxygenase/0.441
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.441
3pqbVGPPutative oxidoreductase/0.441
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4g7gVFVLanosterol 14-alpha-demethylase/0.441
4kp5E1FCarbonic anhydrase 124.2.1.10.441
4kp8E1GCarbonic anhydrase 124.2.1.10.441
1b2lNDCAlcohol dehydrogenase1.1.1.10.440
1fmlRTLRetinol dehydratase/0.440
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.440
1tqf32PBeta-secretase 13.4.23.460.440
1zgi382Prothrombin3.4.21.50.440
1zgv501Prothrombin3.4.21.50.440
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.440
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.440
2dteNAIGlucose 1-dehydrogenase related protein/0.440
2gvcFADThiol-specific monooxygenase1.14.130.440
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.440
2ji9TPWOxalyl-CoA decarboxylase4.1.1.80.440
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.440
2zff53UProthrombin3.4.21.50.440
3biu10UProthrombin3.4.21.50.440
3eq02TSProthrombin3.4.21.50.440
3gwfNAPCyclohexanone monooxygenase/0.440
3iaeD7KBenzaldehyde lyase/0.440
3ixp834Ecdysone receptor/0.440
4bamMM9Prothrombin3.4.21.50.440
4oztP1AEcdysone receptor, putative/0.440