sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 1.000 | |
| 4c59 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.603 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.533 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.516 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.511 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.500 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.497 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.494 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.494 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.491 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.491 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.488 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.488 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.484 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.483 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.482 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.481 | |
| 4njs | G08 | Protease | / | 0.479 | |
| 1c6y | MK1 | Protease | / | 0.478 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.478 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.477 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.476 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.475 | |
| 4q1y | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.475 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.474 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.474 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.473 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.471 | |
| 3so9 | 017 | Pol protein | / | 0.471 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.470 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.470 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.470 | |
| 4hfm | NAP | 2-alkenal reductase (NADP(+)-dependent) | / | 0.470 | |
| 4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.470 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.470 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.469 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.469 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.469 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.469 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.468 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.468 | |
| 1c6z | ROC | Protease | / | 0.467 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.467 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 2x9f | X9F | Ephrin type-B receptor 4 | 2.7.10.1 | 0.466 | |
| 3bvb | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.466 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.466 | |
| 2b9i | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.465 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.465 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.465 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.464 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.463 | |
| 2f3k | RO1 | Protease | / | 0.463 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.463 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.463 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.463 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.463 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.462 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.462 | |
| 1t3r | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.462 | |
| 4iwo | 1H4 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.462 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.461 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.461 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.460 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.460 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.460 | |
| 2i4x | KGQ | Protease | / | 0.460 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.460 | |
| 3gob | HXX | DdmC | / | 0.460 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.460 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.460 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.459 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.459 | |
| 3s43 | 478 | Protease | / | 0.459 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.459 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.458 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.458 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.458 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.458 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 1n49 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.457 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.457 | |
| 4f07 | FAD | Styrene monooxygenase component 2 | / | 0.457 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.457 | |
| 2i0a | MUI | Protease | / | 0.456 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.456 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 3bxr | DRR | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.456 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.456 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 1hvs | A77 | Gag-Pol polyprotein | / | 0.455 | |
| 1pkg | ADP | Mast/stem cell growth factor receptor Kit | 2.7.10.1 | 0.455 | |
| 1w5x | BE5 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.455 | |
| 3liv | E16 | Protease | / | 0.455 | |
| 3v9v | 21L | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.455 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.454 | |
| 1qbr | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.454 | |
| 3nu4 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3vs2 | VSB | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.454 | |
| 3zps | EQM | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.454 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.454 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.453 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2yyl | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.453 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.453 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3lzv | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3sa6 | F71 | Protease | / | 0.453 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.453 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.453 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 1g35 | AHF | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.452 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 2fdd | 385 | Pol protein | / | 0.452 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.452 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.452 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3nxe | 2NC | Protease | / | 0.452 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.452 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.452 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.452 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.452 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.452 | |
| 1daw | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.451 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.451 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1pme | SB2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.451 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.451 | |
| 2uy0 | HV1 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3cyl | VIT | Basic phospholipase A2 homolog piratoxin-2 | / | 0.451 | |
| 3dck | KVI | Protease | / | 0.451 | |
| 3o9b | K2A | Pol polyprotein | / | 0.451 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.451 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1ad5 | ANP | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.450 | |
| 1bdr | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2nnp | ROC | Protease | / | 0.450 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2ycf | YCF | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.450 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.450 | |
| 3ekp | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.450 | |
| 3ggu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3zux | TCH | Transporter | / | 0.450 | |
| 4a4q | UX9 | Pol protein | / | 0.450 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 4xey | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.450 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.450 | |
| 1gqt | ACP | Ribokinase | / | 0.449 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.449 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.449 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2b1p | AIZ | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2q5p | 241 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2uxz | HI1 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3s54 | 017 | Protease | / | 0.449 | |
| 3s56 | ROC | Protease | / | 0.449 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.449 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.449 | |
| 3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 4jbo | WPH | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 5c41 | ACP | Ribokinase | / | 0.449 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.449 | |
| 5ijz | NAP | NADP-specific glutamate dehydrogenase | 1.4.1.4 | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 2ycq | UPX | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.448 | |
| 3vf5 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4bb4 | 32W | Ephrin type-B receptor 4 | 2.7.10.1 | 0.448 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 4ye3 | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.447 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.447 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.447 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.447 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.447 | |
| 3lin | E13 | Protease | / | 0.447 | |
| 3nu6 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4gj2 | 0XH | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.447 | |
| 4hdf | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.447 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.447 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.447 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.447 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.447 | |
| 1hih | C20 | Gag-Pol polyprotein | / | 0.446 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.446 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 2rkf | AB1 | Pol protein | / | 0.446 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.446 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 1bwb | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1hxb | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.445 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2o2u | 738 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 3qai | XNN | Ketohexokinase | / | 0.445 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.445 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.445 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4w9w | YDJ | BMP-2-inducible protein kinase | 2.7.11.1 | 0.445 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.445 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.444 | |
| 1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.444 | |
| 2pk6 | O33 | V-1 protease | / | 0.444 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 3el0 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.444 | |
| 3ocp | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.444 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.444 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.444 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.444 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.444 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.444 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 4njt | 017 | Protease | / | 0.444 | |
| 4wuj | FMN | Glycoside hydrolase family 15, cellulose signaling associated protein envoy | / | 0.444 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.444 | |
| 1izi | Q50 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.443 | |
| 1rw8 | 580 | TGF-beta receptor type-1 | 2.7.11.30 | 0.443 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.443 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 2nnk | ROC | Protease | / | 0.443 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.443 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.443 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 3lit | E15 | Protease | / | 0.443 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.443 | |
| 3otu | BI4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3qaa | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4jbp | YPH | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.443 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.442 | |
| 2b60 | RIT | Pol polyprotein | / | 0.442 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2fy5 | SOP | Choline O-acetyltransferase | 2.3.1.6 | 0.442 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 2hs1 | 017 | Protease | / | 0.442 | |
| 2i4u | DJR | Protease | / | 0.442 | |
| 2oj9 | BMI | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.442 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.442 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.442 | |
| 3dcr | KVS | Protease | / | 0.442 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3gi6 | D78 | Gag-Pol polyprotein | / | 0.442 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.442 | |
| 3nyg | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.442 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.442 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.442 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.442 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.442 | |
| 4ux9 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.442 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.442 | |
| 1c6x | 3IN | Protease | / | 0.441 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2qhy | MZ1 | Gag-Pol polyprotein | / | 0.441 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3o9g | F53 | Gag-Pol polyprotein | / | 0.441 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.441 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 3sa3 | 23X | Protease | / | 0.441 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.441 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.441 | |
| 5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 1fg6 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.440 | |
| 1tcx | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1wbm | BLL | Pol protein | / | 0.440 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.440 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2pvh | P19 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2qnn | QN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2qoc | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
| 2yit | YIT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.440 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.440 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3lpb | NVB | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4djo | MK5 | Pol polyprotein | / | 0.440 | |
| 4f9f | GDP | Putative glycosyltransferase | / | 0.440 | |
| 4l9k | EHF | Serum albumin | / | 0.440 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |