Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 1.000 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.521 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.502 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.499 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.499 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.498 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.497 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.496 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.493 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.493 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.492 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.490 | |
| 4c4i | X20 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.488 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.483 | |
| 3zuy | TCH | Transporter | / | 0.483 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.482 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.481 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.481 | |
| 4gj2 | 0XH | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.481 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.480 | |
| 4kb8 | 1QN | Casein kinase I isoform delta | 2.7.11.1 | 0.480 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.480 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.475 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.475 | |
| 5ap5 | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.475 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.474 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.474 | |
| 1oiu | N76 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.473 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.473 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.473 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.473 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.472 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.472 | |
| 4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.471 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 1ke6 | LS2 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.470 | |
| 2b1p | AIZ | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.470 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.470 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.470 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.469 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.469 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.469 | |
| 1ogu | ST8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.468 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.468 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.468 | |
| 4gih | 0X5 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.468 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.467 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.467 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.467 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.467 | |
| 4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.467 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.467 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.466 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.466 | |
| 3lfn | A27 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 4fv4 | EK7 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.466 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.466 | |
| 4kba | 1QM | Casein kinase I isoform delta | 2.7.11.1 | 0.466 | |
| 4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.466 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.465 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.465 | |
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.465 | |
| 4g6n | EK0 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.465 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.465 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.465 | |
| 2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.464 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.464 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.464 | |
| 1oi9 | N20 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.463 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.463 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.463 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.462 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.462 | |
| 4hgt | 15G | Casein kinase I isoform delta | 2.7.11.1 | 0.462 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.462 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.461 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.461 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.461 | |
| 3sw7 | 19K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4aoj | V4Z | High affinity nerve growth factor receptor | 2.7.10.1 | 0.461 | |
| 4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.461 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.461 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.461 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.460 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.459 | |
| 2j0j | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.459 | |
| 3fi3 | JK2 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.459 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.459 | |
| 3qn8 | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3qtz | X42 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3s1h | 56Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.459 | |
| 3u4u | LNH | Casein kinase II subunit alpha | 2.7.11.1 | 0.459 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.459 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.458 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 3q92 | XNB | Ketohexokinase | / | 0.458 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.458 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.457 | |
| 3r9o | Z71 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4cfn | JYM | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.457 | |
| 4eor | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
| 4n9i | PCG | Catabolite expression activator | / | 0.457 | |
| 4wbo | ANW | Rhodopsin kinase | / | 0.457 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.456 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2r64 | 740 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.456 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.456 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.456 | |
| 4fv0 | EK3 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 2a4l | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.455 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.455 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.455 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.454 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.454 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.454 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.454 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.454 | |
| 4dfn | 0K1 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.454 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 4h4u | NDP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.454 | |
| 4kik | KSA | Inhibitor of nuclear factor kappa-B kinase subunit beta | 2.7.11.10 | 0.454 | |
| 5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.453 | |
| 1pxm | CK5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 1uvr | BI8 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.453 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.453 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.453 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.453 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.453 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4g16 | 0VM | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.453 | |
| 4g1w | G1W | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
| 5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 3qtu | X44 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.452 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.452 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.451 | |
| 2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.451 | |
| 2wmx | ZY6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.451 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3rk9 | 09Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.451 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.451 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.451 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 2r38 | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.450 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.450 | |
| 4bhz | Z0B | Dual specificity protein kinase TTK | 2.7.12.1 | 0.450 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.450 | |
| 5awm | ANP | Stress-activated protein kinase JNK | 2.7.11.24 | 0.450 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.449 | |
| 2b60 | RIT | Pol polyprotein | / | 0.449 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.449 | |
| 3c4w | ATP | Rhodopsin kinase | / | 0.449 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.449 | |
| 3unk | 0BY | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.449 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.449 | |
| 4yuq | KS1 | Calmodulin-like domain protein kinase | / | 0.449 | |
| 5upj | UIN | Gag-Pol polyprotein | / | 0.449 | |
| 2avv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2bts | U32 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.448 | |
| 4g6o | E28 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.448 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.448 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.447 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2izt | 23D | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.447 | |
| 2o0u | C0M | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.447 | |
| 2p3a | 3TL | Pol protein | / | 0.447 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.447 | |
| 2vxo | XMP | GMP synthase [glutamine-hydrolyzing] | 6.3.5.2 | 0.447 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.447 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.447 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3zux | TCH | Transporter | / | 0.447 | |
| 4acm | 7YG | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.447 | |
| 1d4y | TPV | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.446 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2cmw | OLP | Casein kinase I isoform gamma-1 | 2.7.11.1 | 0.446 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.446 | |
| 3hmm | 855 | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.446 | |
| 3pxk | PXK | Focal adhesion kinase 1 | 2.7.10.2 | 0.446 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.446 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.446 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.446 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.446 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.446 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.446 | |
| 1eby | BEB | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1gqt | ACP | Ribokinase | / | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.445 | |
| 3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.445 | |
| 3q9x | EMO | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3qzh | X69 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3sqq | 99Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4bcp | T3C | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4c61 | LMM | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4hge | 15V | Tyrosine-protein kinase JAK2 | / | 0.445 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.445 | |
| 1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.444 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1ke7 | LS3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.444 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2hw1 | ANP | Ketohexokinase | / | 0.444 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.444 | |
| 2w7x | D1A | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.444 | |
| 2zmd | 537 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.444 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3rmf | 20Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.444 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4gfo | 0X2 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.444 | |
| 4lop | SB4 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.444 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.443 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.443 | |
| 2qnn | QN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.443 | |
| 3a7h | ATP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 3qqk | X02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4eol | 1RO | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4h3y | SAH | tRNA (guanine-N(1)-)-methyltransferase | / | 0.443 | |
| 4mbl | 26L | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.443 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.442 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.442 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.442 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 2bqv | A1A | Protease | / | 0.442 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.442 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.442 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.442 | |
| 3ezr | EZR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.442 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.442 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.442 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3vqu | O22 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.442 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.442 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.442 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.442 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2c5n | CK8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2c6o | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.441 | |
| 2r5t | ANP | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.441 | |
| 2xrw | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.441 | |
| 4fyn | 0VE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.441 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.441 | |
| 4jvb | 1M0 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.441 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1hvl | A76 | Gag-Pol polyprotein | / | 0.440 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.440 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2w4i | VGA | Glutamate racemase | / | 0.440 | |
| 2xvd | AS6 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.440 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3nxe | 2NC | Protease | / | 0.440 | |
| 3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3s3r | 0IW | Cathepsin B-like peptidase (C01 family) | / | 0.440 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4bcn | T9N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.440 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.440 |