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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c4h7RODual specificity protein kinase TTK2.7.12.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c4h7RODual specificity protein kinase TTK2.7.12.11.000
4c4iX20Dual specificity protein kinase TTK2.7.12.10.632
4c4f7CEDual specificity protein kinase TTK2.7.12.10.629
4c4g7RODual specificity protein kinase TTK2.7.12.10.624
5ap57RODual specificity protein kinase TTK2.7.12.10.603
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.539
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.534
4c4jX21Dual specificity protein kinase TTK2.7.12.10.508
3vquO22Dual specificity protein kinase TTK2.7.12.10.505
4jbqVX6Aurora kinase A2.7.11.10.500
4gmy0X5Tyrosine-protein kinase JAK2/0.497
2zmd537Dual specificity protein kinase TTK2.7.12.10.495
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.494
3l8p0CEAngiopoietin-1 receptor2.7.10.10.493
4i22IREEpidermal growth factor receptor2.7.10.10.493
2excJNKMitogen-activated protein kinase 102.7.11.240.492
2p33J07Mitogen-activated protein kinase 102.7.11.240.492
4fv9E71Mitogen-activated protein kinase 12.7.11.240.492
1pmn984Mitogen-activated protein kinase 102.7.11.240.491
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.490
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.490
2izsBRQCasein kinase I isoform gamma-32.7.11.10.489
5awmANPStress-activated protein kinase JNK2.7.11.240.489
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.488
5ap7SVEDual specificity protein kinase TTK2.7.12.10.488
2o2u738Mitogen-activated protein kinase 102.7.11.240.487
3ttjJBIMitogen-activated protein kinase 102.7.11.240.487
2hog710Serine/threonine-protein kinase Chk12.7.11.10.486
4hyu1BKMitogen-activated protein kinase 82.7.11.240.486
3ttiKBIMitogen-activated protein kinase 102.7.11.240.485
4nka2K7Fibroblast growth factor receptor 1/0.484
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.482
3uvqFS8Mitogen-activated protein kinase 14/0.481
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.480
2w05FRTCyclin-dependent kinase 22.7.11.220.479
4e730NRMitogen-activated protein kinase 82.7.11.240.479
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.478
4b99R4LMitogen-activated protein kinase 72.7.11.240.478
4bhzZ0BDual specificity protein kinase TTK2.7.12.10.478
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.476
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.476
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
3w2sW2REpidermal growth factor receptor2.7.10.10.475
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2j0m4STFocal adhesion kinase 12.7.10.20.473
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.473
4id71G0Activated CDC42 kinase 1/0.473
4jia1K3Tyrosine-protein kinase JAK2/0.473
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.473
3w18N13Aurora kinase A2.7.11.10.472
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.472
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.472
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.471
2j0k4STFocal adhesion kinase 12.7.10.20.471
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.471
3t8oATPRhodopsin kinase/0.471
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.470
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.470
4jboWPHAurora kinase A2.7.11.10.470
4qmlANPSerine/threonine-protein kinase 242.7.11.10.469
3at4CCKCasein kinase II subunit alpha2.7.11.10.468
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.468
2c6eHPMAurora kinase A2.7.11.10.467
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.467
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.467
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.467
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.466
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.466
3gc9B45Mitogen-activated protein kinase 112.7.11.240.466
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.465
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4hgt15GCasein kinase I isoform delta2.7.11.10.465
1bygSTUTyrosine-protein kinase CSK/0.463
2iw84SPCyclin-dependent kinase 22.7.11.220.463
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.463
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.462
4nks2M2Fibroblast growth factor receptor 1/0.462
2b1pAIZMitogen-activated protein kinase 102.7.11.240.461
2izrBRKCasein kinase I isoform gamma-32.7.11.10.461
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
4gk4L90Ephrin type-A receptor 32.7.10.10.461
4ic7ANPMitogen-activated protein kinase 72.7.11.240.461
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.460
3mpaSB2Mitogen-activated protein kinase 14/0.460
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.460
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.460
1yvj4STTyrosine-protein kinase JAK32.7.10.20.459
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.459
3r9dX6BCyclin-dependent kinase 22.7.11.220.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
4hvi19STyrosine-protein kinase JAK32.7.10.20.459
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.459
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.459
2qo9ANPEphrin type-A receptor 32.7.10.10.458
3a7hATPSerine/threonine-protein kinase 242.7.11.10.458
3ggfGVDSerine/threonine-protein kinase 26/0.458
3icrCOACoenzyme A disulfide reductase/0.458
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.458
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.457
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.456
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.456
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.456
3cgfJNFMitogen-activated protein kinase 102.7.11.240.456
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.456
3ormAGSSerine/threonine protein kinase/0.456
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.456
4aotGW8Serine/threonine-protein kinase 102.7.11.10.456
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.455
2vu3LZECyclin-dependent kinase 22.7.11.220.455
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.455
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.455
4bcmT7ZCyclin-dependent kinase 22.7.11.220.455
4fuxE75Mitogen-activated protein kinase 12.7.11.240.455
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.455
2xvdAS6Ephrin type-B receptor 42.7.10.10.454
3ua506XCytochrome P450 2B61.14.130.454
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.454
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.453
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.453
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.453
2ojj82AMitogen-activated protein kinase 12.7.11.240.453
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.453
4anqVGHALK tyrosine kinase receptor2.7.10.10.453
4ez50RSCyclin-dependent kinase 62.7.11.220.453
4izy1J2Mitogen-activated protein kinase 82.7.11.240.453
4ux9ANPMitogen-activated protein kinase 82.7.11.240.453
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4yuqKS1Calmodulin-like domain protein kinase/0.453
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.452
3c4xATPRhodopsin kinase/0.452
4eevL1XHepatocyte growth factor receptor2.7.10.10.452
5auwQUEDeath-associated protein kinase 12.7.11.10.452
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.451
2bujSTUSerine/threonine-protein kinase 16/0.450
2vd5BI8Myotonin-protein kinase2.7.11.10.450
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.450
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4b8mVX6Aurora kinase B-A2.7.11.10.450
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.450
3kvxFMYMitogen-activated protein kinase 102.7.11.240.449
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.449
3vn2TLSPeroxisome proliferator-activated receptor gamma/0.449
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4g1wG1WMitogen-activated protein kinase 82.7.11.240.449
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.449
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.448
2bxiAZQSerum albumin/0.448
2vrx447Aurora kinase B-A2.7.11.10.448
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.448
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.448
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3ortAGSSerine/threonine protein kinase/0.448
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.448
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4grb0XGCasein kinase II subunit alpha2.7.11.10.448
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2hw1ANPKetohexokinase/0.447
2o0uC0MMitogen-activated protein kinase 102.7.11.240.447
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.447
4cd0AWJALK tyrosine kinase receptor2.7.10.10.447
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.447
5l8lADPAurora kinase A2.7.11.10.447
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.446
1xjdSTUProtein kinase C theta type2.7.11.130.446
2itnANPEpidermal growth factor receptor2.7.10.10.446
2qoqANPEphrin type-A receptor 32.7.10.10.446
2xp2VGHALK tyrosine kinase receptor2.7.10.10.446
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.446
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.446
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.446
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.445
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
3w2rW2REpidermal growth factor receptor2.7.10.10.445
4b7xNAPProbable oxidoreductase/0.445
4c3pACPAurora kinase A2.7.11.10.445
4qmzB49Serine/threonine-protein kinase 242.7.11.10.445
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.444
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.444
3ztxZTXAurora kinase B-A2.7.11.10.444
4j97ACPFibroblast growth factor receptor 2/0.444
4kba1QMCasein kinase I isoform delta2.7.11.10.444
1oi9N20Cyclin-dependent kinase 22.7.11.220.443
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.443
3eljGS7Mitogen-activated protein kinase 82.7.11.240.443
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.443
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.443
2wqeADPAurora kinase A2.7.11.10.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.442
3wowANPCasein kinase II subunit alpha2.7.11.10.442
4ansVGHALK tyrosine kinase receptor2.7.10.10.442
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.442
4jqeANPCasein kinase II subunit alpha2.7.11.10.442
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
4wsqKSAAP2-associated protein kinase 12.7.11.10.442
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
2djiFADPyruvate oxidase/0.441
2henADPEphrin type-B receptor 22.7.10.10.441
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.441
3uvp048Mitogen-activated protein kinase 14/0.441
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.441
4hnf16WCasein kinase I isoform delta2.7.11.10.441
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.441
5cvfATPCasein kinase II subunit alpha2.7.11.10.441
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.440
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.440
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.440
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.440
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.440
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.440
4wboANWRhodopsin kinase/0.440
4xhgADPUncharacterized protein/0.440