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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c4g7RODual specificity protein kinase TTK2.7.12.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c4g7RODual specificity protein kinase TTK2.7.12.11.000
4c4f7CEDual specificity protein kinase TTK2.7.12.10.639
4c4iX20Dual specificity protein kinase TTK2.7.12.10.632
4c4h7RODual specificity protein kinase TTK2.7.12.10.628
5ap57RODual specificity protein kinase TTK2.7.12.10.578
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.542
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.530
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.528
5ap7SVEDual specificity protein kinase TTK2.7.12.10.508
4fv9E71Mitogen-activated protein kinase 12.7.11.240.504
4i22IREEpidermal growth factor receptor2.7.10.10.500
1pmn984Mitogen-activated protein kinase 102.7.11.240.499
3l8p0CEAngiopoietin-1 receptor2.7.10.10.494
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.490
3vquO22Dual specificity protein kinase TTK2.7.12.10.489
2vu3LZECyclin-dependent kinase 22.7.11.220.488
2c6eHPMAurora kinase A2.7.11.10.486
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4gmy0X5Tyrosine-protein kinase JAK2/0.485
3gc9B45Mitogen-activated protein kinase 112.7.11.240.484
2j0m4STFocal adhesion kinase 12.7.10.20.482
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.482
2w05FRTCyclin-dependent kinase 22.7.11.220.481
2zmd537Dual specificity protein kinase TTK2.7.12.10.481
5awmANPStress-activated protein kinase JNK2.7.11.240.481
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.480
3ttjJBIMitogen-activated protein kinase 102.7.11.240.480
5l8lADPAurora kinase A2.7.11.10.480
3w18N13Aurora kinase A2.7.11.10.478
4nka2K7Fibroblast growth factor receptor 1/0.478
2o2u738Mitogen-activated protein kinase 102.7.11.240.477
3at4CCKCasein kinase II subunit alpha2.7.11.10.476
4jbqVX6Aurora kinase A2.7.11.10.475
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.474
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.472
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.472
3ttiKBIMitogen-activated protein kinase 102.7.11.240.471
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.469
2qoqANPEphrin type-A receptor 32.7.10.10.469
3qu0X40Cyclin-dependent kinase 22.7.11.220.469
4hyu1BKMitogen-activated protein kinase 82.7.11.240.467
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.467
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.467
3cgfJNFMitogen-activated protein kinase 102.7.11.240.466
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.465
4id71G0Activated CDC42 kinase 1/0.465
2p33J07Mitogen-activated protein kinase 102.7.11.240.464
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.464
4ez50RSCyclin-dependent kinase 62.7.11.220.464
3t2kFADSulfide-quinone reductase/0.463
2excJNKMitogen-activated protein kinase 102.7.11.240.462
4e730NRMitogen-activated protein kinase 82.7.11.240.462
4qmlANPSerine/threonine-protein kinase 242.7.11.10.461
2hog710Serine/threonine-protein kinase Chk12.7.11.10.460
2wqeADPAurora kinase A2.7.11.10.460
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.460
4b99R4LMitogen-activated protein kinase 72.7.11.240.460
4g1wG1WMitogen-activated protein kinase 82.7.11.240.460
2o0uC0MMitogen-activated protein kinase 102.7.11.240.459
3eljGS7Mitogen-activated protein kinase 82.7.11.240.459
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.459
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.459
2fvdLIACyclin-dependent kinase 22.7.11.220.458
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.458
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.457
3r9dX6BCyclin-dependent kinase 22.7.11.220.457
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.457
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.456
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.456
2xvdAS6Ephrin type-B receptor 42.7.10.10.456
4fob0USALK tyrosine kinase receptor2.7.10.10.456
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.455
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.455
4h3qANPMitogen-activated protein kinase 12.7.11.240.455
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3i60E86Mitogen-activated protein kinase 12.7.11.240.454
3k5uPFQAurora kinase A2.7.11.10.454
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.454
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4aotGW8Serine/threonine-protein kinase 102.7.11.10.454
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4qo9627Serine/threonine-protein kinase 242.7.11.10.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.453
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
2iw84SPCyclin-dependent kinase 22.7.11.220.452
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.452
3uvqFS8Mitogen-activated protein kinase 14/0.452
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.452
4gk4L90Ephrin type-A receptor 32.7.10.10.452
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.451
3kvxFMYMitogen-activated protein kinase 102.7.11.240.451
3my5RFZCyclin-dependent kinase 22.7.11.220.451
3t8oATPRhodopsin kinase/0.451
4bcnT9NCyclin-dependent kinase 22.7.11.220.451
4c58824Cyclin-G-associated kinase2.7.11.10.451
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3w2sW2REpidermal growth factor receptor2.7.10.10.449
4jbpYPHAurora kinase A2.7.11.10.449
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2b1pAIZMitogen-activated protein kinase 102.7.11.240.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
2qo9ANPEphrin type-A receptor 32.7.10.10.448
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.448
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.448
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
4o0uADNAurora kinase A2.7.11.10.447
4o0wADNAurora kinase A2.7.11.10.447
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.446
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.446
4bcmT7ZCyclin-dependent kinase 22.7.11.220.446
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.446
4jboWPHAurora kinase A2.7.11.10.446
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.446
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.445
2aazCB3Thymidylate synthase2.1.1.450.445
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.445
2zdt46CMitogen-activated protein kinase 102.7.11.240.445
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.445
3ddqRRCCyclin-dependent kinase 22.7.11.220.445
3mpaSB2Mitogen-activated protein kinase 14/0.445
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.445
4aguD15Cyclin-dependent kinase-like 1/0.445
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.444
4ansVGHALK tyrosine kinase receptor2.7.10.10.444
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
4izy1J2Mitogen-activated protein kinase 82.7.11.240.444
4utdACPAurora kinase A2.7.11.10.444
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1h1r6CPCyclin-dependent kinase 22.7.11.220.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
3ztxZTXAurora kinase B-A2.7.11.10.443
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.442
2vrx447Aurora kinase B-A2.7.11.10.442
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.442
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4jia1K3Tyrosine-protein kinase JAK2/0.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.441
3c4zADPRhodopsin kinase/0.441
3cgoJNOMitogen-activated protein kinase 102.7.11.240.441
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.441
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.441
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.441
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.441
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.441
4yuqKS1Calmodulin-like domain protein kinase/0.441
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.440
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.440
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.440
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.440
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4anqVGHALK tyrosine kinase receptor2.7.10.10.440
4bbe3O4Tyrosine-protein kinase JAK2/0.440
4fuxE75Mitogen-activated protein kinase 12.7.11.240.440