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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4c4f7CEDual specificity protein kinase TTK2.7.12.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4c4f7CEDual specificity protein kinase TTK2.7.12.11.000
4c4h7RODual specificity protein kinase TTK2.7.12.10.613
4c4g7RODual specificity protein kinase TTK2.7.12.10.603
4c4iX20Dual specificity protein kinase TTK2.7.12.10.599
5ap57RODual specificity protein kinase TTK2.7.12.10.572
5ap7SVEDual specificity protein kinase TTK2.7.12.10.502
4hyu1BKMitogen-activated protein kinase 82.7.11.240.500
4bi1ZO6Dual specificity protein kinase TTK2.7.12.10.496
1pmn984Mitogen-activated protein kinase 102.7.11.240.494
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.481
3vquO22Dual specificity protein kinase TTK2.7.12.10.479
4fv9E71Mitogen-activated protein kinase 12.7.11.240.478
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.477
3ttjJBIMitogen-activated protein kinase 102.7.11.240.476
4bhzZ0BDual specificity protein kinase TTK2.7.12.10.473
2excJNKMitogen-activated protein kinase 102.7.11.240.472
2p33J07Mitogen-activated protein kinase 102.7.11.240.472
2o2u738Mitogen-activated protein kinase 102.7.11.240.471
3cgfJNFMitogen-activated protein kinase 102.7.11.240.471
3ttiKBIMitogen-activated protein kinase 102.7.11.240.465
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.460
4e730NRMitogen-activated protein kinase 82.7.11.240.460
2o0uC0MMitogen-activated protein kinase 102.7.11.240.459
3k5uPFQAurora kinase A2.7.11.10.459
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.459
2iw84SPCyclin-dependent kinase 22.7.11.220.458
2zmd537Dual specificity protein kinase TTK2.7.12.10.458
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.456
5awmANPStress-activated protein kinase JNK2.7.11.240.456
2aazCB3Thymidylate synthase2.1.1.450.455
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.455
4g1wG1WMitogen-activated protein kinase 82.7.11.240.455
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.455
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.454
5l8lADPAurora kinase A2.7.11.10.454
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.453
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.452
4izy1J2Mitogen-activated protein kinase 82.7.11.240.452
2wqeADPAurora kinase A2.7.11.10.451
3l8p0CEAngiopoietin-1 receptor2.7.10.10.450
4gmy0X5Tyrosine-protein kinase JAK2/0.450
4jbqVX6Aurora kinase A2.7.11.10.450
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.448
3ormAGSSerine/threonine protein kinase/0.448
2c6eHPMAurora kinase A2.7.11.10.447
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
3axwTIDCasein kinase II subunit alpha2.7.11.10.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
1bygSTUTyrosine-protein kinase CSK/0.444
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.443
2b1pAIZMitogen-activated protein kinase 102.7.11.240.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
4id71G0Activated CDC42 kinase 1/0.442
4c58824Cyclin-G-associated kinase2.7.11.10.441
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.440