sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4c36 | ZO9 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 1.000 | |
| 3l9n | L9N | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.559 | |
| 3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.551 | |
| 4c35 | NU3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.548 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.543 | |
| 3u9n | 09H | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.540 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.540 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.539 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.538 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.537 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.531 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.531 | |
| 2jdv | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.524 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.521 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.515 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.509 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.506 | |
| 2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.503 | |
| 2ojg | 19A | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.502 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.501 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.500 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.499 | |
| 2gnf | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.498 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.495 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.495 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.493 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.493 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.489 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.489 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.487 | |
| 2uw4 | L15 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.484 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.484 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.484 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.483 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.483 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.482 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.482 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.480 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.480 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.480 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.479 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.478 | |
| 2ojf | 4PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.477 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.475 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.474 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 3bwj | ARX | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.474 | |
| 4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.474 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.473 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 4ng2 | OHN | Transcriptional activator protein LasR | / | 0.472 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 2vuw | 5ID | Serine/threonine-protein kinase haspin | 2.7.11.1 | 0.471 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.471 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.471 | |
| 4rrr | A3T | Threonine--tRNA ligase | 6.1.1.3 | 0.471 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.470 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.470 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.470 | |
| 2vo6 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.469 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.468 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.468 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.468 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.467 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.467 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.467 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.466 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.466 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.466 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.465 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.464 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.464 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.464 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.463 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.463 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.463 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.463 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.462 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.462 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 3zo1 | SIJ | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 2f7z | 6EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.459 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.459 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.459 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3iod | A6D | Pantothenate synthetase | 6.3.2.1 | 0.459 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.459 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1rp7 | TZD | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.458 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.457 | |
| 4bie | IE6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.457 | |
| 1eio | GCH | Gastrotropin | / | 0.456 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.456 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.456 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.456 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 4iaz | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.456 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.455 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.455 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.455 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.455 | |
| 3ime | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.455 | |
| 4gh2 | HK0 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.455 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 1q8t | Y27 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.454 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2c4j | GSO | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.454 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.454 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 4la7 | A1O | Abscisic acid receptor PYL2 | / | 0.454 | |
| 4wbb | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 1c7o | PPG | Hemolysin | / | 0.453 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.453 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.453 | |
| 3ncz | 3NC | Rho-associated protein kinase 1 | 2.7.11.1 | 0.453 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.453 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4gvj | ADP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.453 | |
| 4j1r | I5R | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.453 | |
| 1gax | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.452 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3tku | M77 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.452 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.452 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4ck2 | NVU | Integrase | / | 0.452 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.451 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.451 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2qfv | NAP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.451 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.451 | |
| 4acg | 6LQ | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.451 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.451 | |
| 1h62 | ANB | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.450 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.450 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3fow | IMH | Purine nucleoside phosphorylase | / | 0.450 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 1k7f | IAV | Tryptophan synthase alpha chain | / | 0.449 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.449 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.449 | |
| 3dnd | LL2 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 3eks | CY9 | Actin-5C | / | 0.449 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.449 | |
| 4acc | 7YG | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.449 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.449 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.448 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.448 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.448 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.448 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.448 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.447 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.447 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.447 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.447 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.447 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.447 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.447 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.447 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 5dn1 | AMZ | Phosphoribosyl isomerase A | 5.3.1.16 | 0.447 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2pmn | K51 | Protein kinase 7 | / | 0.446 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.446 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.446 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.446 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.446 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.446 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.446 | |
| 3v2u | ATP | Protein GAL3 | / | 0.446 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.446 | |
| 4n6z | 2HW | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.446 | |
| 4nif | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.446 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2bei | ACO | Diamine acetyltransferase 2 | 2.3.1.57 | 0.445 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.445 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.445 | |
| 2jj8 | AZZ | Deoxynucleoside kinase | / | 0.445 | |
| 2ohv | NHL | Glutamate racemase | / | 0.445 | |
| 2pml | ANP | Uncharacterized protein | / | 0.445 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.445 | |
| 4f70 | 0ST | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.445 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1qrt | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.444 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.444 | |
| 2xf3 | J01 | Uncharacterized protein | / | 0.444 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 3eku | CY9 | Actin-5C | / | 0.444 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.444 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.444 | |
| 4iah | 1DX | Alr2278 protein | / | 0.444 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.443 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.443 | |
| 1yi3 | LY2 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.443 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.443 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.443 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3td7 | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.443 | |
| 3uix | Q17 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 1oya | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.442 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.442 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.442 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.442 | |
| 2r3a | SAM | Histone-lysine N-methyltransferase SUV39H2 | 2.1.1.43 | 0.442 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.442 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3nie | ANP | Mitogen-activated protein kinase | / | 0.442 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.442 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.442 | |
| 4acd | GR9 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.442 | |
| 4blc | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4iae | 1DX | Alr2278 protein | / | 0.442 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.442 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.442 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.442 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1j1b | ANP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.441 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.441 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.441 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.441 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.441 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.441 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.441 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.441 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.441 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.441 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.441 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1e8z | STU | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1el4 | CTZ | Obelin | / | 0.440 | |
| 1gal | FAD | Glucose oxidase | 1.1.3.4 | 0.440 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.440 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.440 | |
| 2uvy | GVI | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2xsz | ATP | RuvB-like 2 | 3.6.4.12 | 0.440 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.440 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.440 | |
| 3gep | 24H | Hypoxanthine-guanine phosphoribosyltransferase | 2.4.2.8 | 0.440 | |
| 3oog | YTP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3up5 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.440 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.440 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.440 | |
| 4hnc | 0UT | Mandelate racemase | / | 0.440 | |
| 4kc1 | WS1 | Histo-blood group ABO system transferase | / | 0.440 | |
| 4kc2 | WS2 | Histo-blood group ABO system transferase | / | 0.440 | |
| 5f8f | SFG | Possible transcriptional regulatory protein | / | 0.440 |