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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bznUGXSerine/threonine-protein kinase pim-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bznUGXSerine/threonine-protein kinase pim-12.7.11.11.000
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.740
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.589
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.581
2xj2985Serine/threonine-protein kinase pim-12.7.11.10.576
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.570
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.564
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.563
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.561
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.560
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.550
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.548
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.547
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.547
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.546
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.535
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.533
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.533
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.528
4bgg844Activin receptor type-12.7.11.300.528
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.524
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.521
4dymIYZActivin receptor type-12.7.11.300.515
3mtfA3FActivin receptor type-12.7.11.300.513
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.513
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.511
3umw596Serine/threonine-protein kinase pim-12.7.11.10.510
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.510
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.509
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.509
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.509
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.505
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.503
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.502
2cdaNAPGlucose 1-dehydrogenase/0.499
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.499
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.496
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.496
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.496
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.496
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.495
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.493
3oqkS52Renin3.4.23.150.492
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.490
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.490
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.489
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.488
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.487
2uxoTACHTH-type transcriptional regulator TtgR/0.486
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.486
3own3OWRenin3.4.23.150.485
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.483
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.481
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.480
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.480
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.478
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.477
2wihP48Cyclin-dependent kinase 22.7.11.220.477
3hx4ANPCalmodulin-domain protein kinase 1/0.477
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.477
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.477
2pvlP55Casein kinase II subunit alpha2.7.11.10.476
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.476
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.475
1m13HYFNuclear receptor subfamily 1 group I member 2/0.474
3pe2E1BCasein kinase II subunit alpha2.7.11.10.474
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
1xjdSTUProtein kinase C theta type2.7.11.130.473
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.472
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.472
3nga3NGCasein kinase II subunit alpha2.7.11.10.472
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.472
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.471
3ibqATPPyridoxal kinase/0.471
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.470
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.470
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
1bxoPP7Penicillopepsin-13.4.23.200.468
1rfuADPPyridoxal kinase2.7.1.350.467
4hge15VTyrosine-protein kinase JAK2/0.467
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.467
4c02TAKActivin receptor type-12.7.11.300.466
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.465
1h1s4SPCyclin-dependent kinase 22.7.11.220.464
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.464
2wxvWXVCyclin-dependent kinase 22.7.11.220.464
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.464
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.463
4i22IREEpidermal growth factor receptor2.7.10.10.463
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.463
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2iw84SPCyclin-dependent kinase 22.7.11.220.462
3be9P04Casein kinase II subunit alpha2.7.11.10.462
3hllI45Mitogen-activated protein kinase 14/0.462
2iko7IGRenin3.4.23.150.461
2xiyXIYSerine/threonine-protein kinase pim-12.7.11.10.461
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.461
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.461
4z63ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.461
5cvhADPCasein kinase II subunit alpha2.7.11.10.461
1fmjRTLRetinol dehydratase/0.460
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.460
3bhtMFRCyclin-dependent kinase 22.7.11.220.460
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.460
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.460
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
2om9AJAPeroxisome proliferator-activated receptor gamma/0.459
2i4qUA4Renin3.4.23.150.458
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.458
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.458
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.457
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.456
2pvhP19Casein kinase II subunit alpha2.7.11.10.456
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.456
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.456
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.456
5f8eSAHPossible transcriptional regulatory protein/0.456
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.455
3eljGS7Mitogen-activated protein kinase 82.7.11.240.455
3vsoEK1Peroxisome proliferator-activated receptor gamma/0.455
2nq8ZIDEnoyl-ACP reductase/0.454
3q9zTXQCasein kinase II subunit alpha2.7.11.10.454
4a8v2ANMajor pollen allergen Bet v 1-J/0.454
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.454
4ivb1J5Tyrosine-protein kinase JAK1/0.454
4qmySTUSerine/threonine-protein kinase 242.7.11.10.454
1xddAAYIntegrin alpha-L/0.453
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.453
3dogNNNCyclin-dependent kinase 22.7.11.220.453
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.453
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.453
4jq8KJ8Epidermal growth factor receptor2.7.10.10.453
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.453
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.453
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.453
2in6839Wee1-like protein kinase2.7.10.20.452
2pvnP63Casein kinase II subunit alpha2.7.11.10.452
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3rak03ZCyclin-dependent kinase 22.7.11.220.452
3ral04ZCyclin-dependent kinase 22.7.11.220.452
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.452
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
1dawANPCasein kinase II subunit alpha2.7.11.10.451
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.451
2cchATPCyclin-dependent kinase 22.7.11.220.451
2q9fC3SCholesterol 24-hydroxylase/0.451
4a83DXCMajor pollen allergen Bet v 1-A/0.451
4anmWULCasein kinase II subunit alpha2.7.11.10.451
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.451
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.451
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.451
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
1m2pHNACasein kinase II subunit alpha2.7.11.10.450
1ppm0P1Penicillopepsin-13.4.23.200.450
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.450
1zg32HIIsoflavone 4'-O-methyltransferase/0.450
3s1h56ZCyclin-dependent kinase 22.7.11.220.450
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.450
4gmy0X5Tyrosine-protein kinase JAK2/0.450
1cqp803Integrin alpha-L/0.449
1ndzFR5Adenosine deaminase3.5.4.40.449
2pauD5M5'-deoxynucleotidase YfbR/0.449
3akn11DFatty acid-binding protein, intestinal/0.449
3oom507Activin receptor type-12.7.11.300.449
3q9xEMOCasein kinase II subunit alpha2.7.11.10.449
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
4ux9ANPMitogen-activated protein kinase 82.7.11.240.449
5depUD1Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase/0.449
1m2rMNYCasein kinase II subunit alpha2.7.11.10.448
1zgaHMKIsoflavone 4'-O-methyltransferase/0.448
2bkzSBCCyclin-dependent kinase 22.7.11.220.448
2p5uNADUDP-glucose 4-epimerase/0.448
2wedPP6Penicillopepsin-13.4.23.200.448
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.448
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.448
1rfvADPPyridoxal kinase2.7.1.350.447
1sxjAGSReplication factor C subunit 1/0.447
2x1nX1NCyclin-dependent kinase 22.7.11.220.447
3livE16Protease/0.447
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.447
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.447
4a862ANMajor pollen allergen Bet v 1-A/0.447
4ax8ADPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.447
4btjATPTau-tubulin kinase 12.7.11.10.447
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.447
4tuvCPZCytochrome P450 1191.140.447
1eh4IC1Casein kinase I homolog 12.7.11.10.446
1gih1PUCyclin-dependent kinase 22.7.11.220.446
2dvlFADAcyl-CoA dehydrogenase/0.446
2ikuLIYRenin3.4.23.150.446
2izrBRKCasein kinase I isoform gamma-32.7.11.10.446
2pmoHMDProtein kinase 7/0.446
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.446
3mb714ICasein kinase II subunit alpha2.7.11.10.446
3vtbTKAVitamin D3 receptor/0.446
4a87NARMajor pollen allergen Bet v 1-A/0.446
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.446
4fx360KCyclin-dependent kinase 22.7.11.220.446
1k7fIAVTryptophan synthase alpha chain/0.445
1om1IQACasein kinase II subunit alpha2.7.11.10.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
3r0tFU9Casein kinase II subunit alpha2.7.11.10.445
3rk708ZCyclin-dependent kinase 22.7.11.220.445
3rmf20ZCyclin-dependent kinase 22.7.11.220.445
4ez50RSCyclin-dependent kinase 62.7.11.220.445
4klaCHDFerrochelatase, mitochondrial4.99.1.10.445
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.445
4lxhC1EAlpha/beta hydrolase fold/0.445
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.445
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.444
2uzbC75Cyclin-dependent kinase 22.7.11.220.444
2xa4AZ5Tyrosine-protein kinase JAK2/0.444
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.444
4an4DUDPutative glycosyl transferase/0.444
4bchT7ZCyclin-dependent kinase 92.7.11.220.444
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
1psa0ZLPepsin A3.4.23.10.443
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.443
3ad9NADSubunit alpha of sarocosine oxidase/0.443
3gu7ADPDeath-associated protein kinase 12.7.11.10.443
3gwfNAPCyclohexanone monooxygenase/0.443
3hyoADPPyridoxal kinase/0.443
4enhFVXCholesterol 24-hydroxylase/0.443
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
5cvfATPCasein kinase II subunit alpha2.7.11.10.443
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.442
2ojg19AMitogen-activated protein kinase 12.7.11.240.442
2q5g1FAPeroxisome proliferator-activated receptor delta/0.442
3vtdTKDVitamin D3 receptor/0.442
4a81DXCMajor pollen allergen Bet v 1-A/0.442
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.442
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.442
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.442
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.442
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1qxlFR8Adenosine deaminase3.5.4.40.441
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.441
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.441
2wpa889Cyclin-dependent kinase 22.7.11.220.441
3hmm855TGF-beta receptor type-12.7.11.300.441
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.441
3r7kFDAProbable acyl CoA dehydrogenase/0.441
3vt8YI3Vitamin D3 receptor/0.441
4bgq38RCyclin-dependent kinase-like 52.7.11.220.441
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
4q73FADBifunctional protein PutA/0.441
5a3cNADSIR2 family protein/0.441
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.441
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.441
1zys199Serine/threonine-protein kinase Chk12.7.11.10.440
3oroAGSSerine/threonine protein kinase/0.440
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.440
4btjADPTau-tubulin kinase 12.7.11.10.440
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.440
4hvh19RTyrosine-protein kinase JAK32.7.10.20.440
4iah1DXAlr2278 protein/0.440