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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4buv16ITankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4buv16ITankyrase-22.4.2.301.000
4bufF36Tankyrase-22.4.2.300.714
4hkiFLNTankyrase-22.4.2.300.706
4buiW2ETankyrase-22.4.2.300.702
4l33F70Tankyrase-22.4.2.300.678
4buuF38Tankyrase-22.4.2.300.670
4bu908CTankyrase-22.4.2.300.659
4but31FTankyrase-22.4.2.300.654
4l0s1UZTankyrase-22.4.2.300.644
4l2f1V3Tankyrase-22.4.2.300.640
4hlk431Tankyrase-22.4.2.300.631
5aku29FTankyrase-22.4.2.300.622
4avwG18Tankyrase-22.4.2.300.614
4kzl20DTankyrase-22.4.2.300.613
3kr8XAVTankyrase-22.4.2.300.610
4bueJQFTankyrase-22.4.2.300.599
4buxF35Tankyrase-22.4.2.300.599
4hlg20BTankyrase-22.4.2.300.590
4l0i1UWTankyrase-22.4.2.300.590
4l10A63Tankyrase-22.4.2.300.584
4buwF33Tankyrase-22.4.2.300.580
4l31F08Tankyrase-22.4.2.300.578
4l321VFTankyrase-22.4.2.300.576
4bus32FTankyrase-22.4.2.300.575
4bud29FTankyrase-22.4.2.300.573
4hmhF94Tankyrase-22.4.2.300.572
4l091URTankyrase-22.4.2.300.569
4l2k1V8Tankyrase-22.4.2.300.569
4l341VGTankyrase-22.4.2.300.567
4bs4A64Tankyrase-22.4.2.300.564
4l0t1V0Tankyrase-22.4.2.300.564
4hlm16STankyrase-22.4.2.300.563
4l0v1V1Tankyrase-22.4.2.300.561
4hkkAGITankyrase-22.4.2.300.560
4iueAJ4Tankyrase-22.4.2.300.559
4j22AJ7Tankyrase-22.4.2.300.557
4hl515WTankyrase-22.4.2.300.556
4hlf15ZTankyrase-22.4.2.300.551
4hlh20DTankyrase-22.4.2.300.551
4hknLU2Tankyrase-22.4.2.300.546
3p0pNNFTankyrase-22.4.2.300.540
4j21AJ6Tankyrase-22.4.2.300.536
4kzuA73Tankyrase-22.4.2.300.535
4l2g1V4Tankyrase-22.4.2.300.534
4j3mAJ8Tankyrase-22.4.2.300.532
4krs1SXTankyrase-12.4.2.300.525
4j3lAJ5Tankyrase-22.4.2.300.523
4avuLDRTankyrase-22.4.2.300.517
4pnrG18Tankyrase-22.4.2.300.482
1uh5TCLEnoyl-ACP reductase/0.479
4tkg09LTankyrase-22.4.2.300.478
4zm6ACON-acetyl-beta-D glucosaminidase/0.470
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.462
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.462
4dvi2IWTankyrase-12.4.2.300.462
3f4bTCLEnoyl-acyl carrier protein reductase/0.461
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.459
3tk0FADFAD-linked sulfhydryl oxidase ALR1.8.3.20.458
4msk2C8Tankyrase-12.4.2.300.458
1zw1TN5Enoyl-ACP reductase/0.457
3u2mFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.457
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.456
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3nj8NJ8Enoyl-acyl carrier reductase/0.456
4i9i1DYTankyrase-12.4.2.300.456
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.455
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4bfvZVVPantothenate kinase2.7.1.330.455
1ay0TPPTransketolase 12.2.1.10.454
4s0vSUVOrexin receptor type 2/0.454
2o2yTCLEnoyl-ACP reductase/0.452
3lt2FT3Enoyl-ACP reductase/0.452
4rv9SAHD-mycarose 3-C-methyltransferase/0.452
4xg1LLPDiaminopimelate decarboxylase/0.452
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
1zxlJP1Enoyl-ACP reductase/0.450
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3jpuTY4Transcriptional activator protein LasR/0.450
1fm4DXCMajor pollen allergen Bet v 1-L/0.449
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.449
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.449
3pm9FADPutative oxidoreductase/0.449
3sn6P0GBeta-2 adrenergic receptor/0.449
1rrmAPRLactaldehyde reductase1.1.1.770.448
1sepBIOSepiapterin reductase1.1.1.1530.448
2op07PCEnoyl-ACP reductase/0.448
2vcwZZAHematopoietic prostaglandin D synthase/0.448
2zevB71Geranylgeranyl pyrophosphate synthase/0.448
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
1kzjCB3Thymidylate synthase/0.447
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
3am5TCLEnoyl-ACP reductase/0.447
3mdeCO8Medium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.447
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.447
5bt42LOBromodomain-containing protein 4/0.447
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.446
1f0lAPUDiphtheria toxin/0.445
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.445
2vcxD26Hematopoietic prostaglandin D synthase/0.445
3qgd26SGenome polyprotein2.7.7.480.445
4epq0RRPoly(ADP-ribose) glycohydrolase/0.445
4ly91YYGlucokinase regulatory protein/0.445
1lnmDTXBilin-binding protein/0.444
3am4FT1Enoyl-ACP reductase/0.444
3exnACOProbable acetyltransferase/0.444
3gkjHC3Niemann-Pick C1 protein/0.444
3ipuO40Oxysterols receptor LXR-alpha/0.444
4xzjNADPutative NAD(+)--arginine ADP-ribosyltransferase Vis2.4.2.310.444
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1trgCB3Thymidylate synthase/0.443
2ol4JPNEnoyl-ACP reductase/0.443
3djfBC3Purine nucleoside phosphorylase/0.443
3nrcTCLEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4b5pACOAlpha-tubulin N-acetyltransferase 1/0.443
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.442
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1h61PDNPentaerythritol tetranitrate reductase/0.442
1xp6AIUEstrogen receptor/0.442
2bu9HFVIsopenicillin N synthase1.21.3.10.442
3biy01KHistone acetyltransferase p300/0.442
3fnhJPJEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4bj9UHBTankyrase-22.4.2.300.442
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
1nhgTCLEnoyl-ACP reductase/0.441
3v0o4GWHisto-blood group ABO system transferase/0.441
2w98P1ZProstaglandin reductase 21.3.1.480.440
3jynNDPQuinone oxidoreductase/0.440
3lt1FT2Enoyl-ACP reductase/0.440
4m9aFDAAcyl-CoA dehydrogenase/0.440
4n1gCEIObelin/0.440
4tjy3GNTankyrase-22.4.2.300.440
2yczI32Beta-1 adrenergic receptor/0.440