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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4btkDTQTau-tubulin kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4btkDTQTau-tubulin kinase 12.7.11.11.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.526
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.488
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.486
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.483
4nfn2KCTau-tubulin kinase 12.7.11.10.480
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.479
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.478
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.478
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.476
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.475
1m17AQ4Epidermal growth factor receptor2.7.10.10.474
2itzIREEpidermal growth factor receptor2.7.10.10.474
4j97ACPFibroblast growth factor receptor 2/0.474
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.473
4nka2K7Fibroblast growth factor receptor 1/0.472
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.471
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.470
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.469
3vs3VSETyrosine-protein kinase HCK2.7.10.20.468
2fgiPD1Fibroblast growth factor receptor 1/0.467
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.467
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.467
3w33W19Epidermal growth factor receptor2.7.10.10.467
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.466
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
4nks2M2Fibroblast growth factor receptor 1/0.466
2henADPEphrin type-B receptor 22.7.10.10.465
4nk92K5Fibroblast growth factor receptor 1/0.465
2c6eHPMAurora kinase A2.7.11.10.464
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.464
4btjADPTau-tubulin kinase 12.7.11.10.464
4i22IREEpidermal growth factor receptor2.7.10.10.464
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2hog710Serine/threonine-protein kinase Chk12.7.11.10.462
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.462
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.461
4f640S8Fibroblast growth factor receptor 1/0.461
1zyjBI5Mitogen-activated protein kinase 14/0.460
2excJNKMitogen-activated protein kinase 102.7.11.240.460
3w2sW2REpidermal growth factor receptor2.7.10.10.460
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.458
4b7dQLECytochrome P450 monooxygenase PikC/0.458
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.457
1ml3NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.456
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.456
4ic7ANPMitogen-activated protein kinase 72.7.11.240.456
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.455
3w32W32Epidermal growth factor receptor2.7.10.10.455
4jq8KJ8Epidermal growth factor receptor2.7.10.10.455
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.455
3vryB43Tyrosine-protein kinase HCK2.7.10.20.454
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.453
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.453
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.453
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.452
3js2VM1Fibroblast growth factor receptor 1/0.452
3bu5ATPInsulin receptor2.7.10.10.451
3flwFLWMitogen-activated protein kinase 14/0.451
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.451
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.451
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
2pwlACPFibroblast growth factor receptor 2/0.450
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.450
5dc5B3NHistone deacetylase 83.5.1.980.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.448
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.448
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4hvh19RTyrosine-protein kinase JAK32.7.10.20.448
4xhgADPUncharacterized protein/0.448
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.447
3uvqFS8Mitogen-activated protein kinase 14/0.446
4r21STRCytochrome P450 family 17 polypeptide 2/0.446
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
4hvi19STyrosine-protein kinase JAK32.7.10.20.445
4i231C9Epidermal growth factor receptor2.7.10.10.445
4jr3KJREpidermal growth factor receptor2.7.10.10.445
4r20AERCytochrome P450 family 17 polypeptide 2/0.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
2nnhREACytochrome P450 2C8/0.443
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.443
4id71G0Activated CDC42 kinase 1/0.443
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3kf7L9GMitogen-activated protein kinase 14/0.442
3mvl38PMitogen-activated protein kinase 14/0.442
3uvp048Mitogen-activated protein kinase 14/0.442
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.442
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3a1l2CCCytochrome P450/0.440
3hllI45Mitogen-activated protein kinase 14/0.440
3vjoANPEpidermal growth factor receptor2.7.10.10.440
4hjoAQ4Epidermal growth factor receptor2.7.10.10.440