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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bs4A64Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bs4A64Tankyrase-22.4.2.301.000
4buxF35Tankyrase-22.4.2.300.871
4l0t1V0Tankyrase-22.4.2.300.853
4bueJQFTankyrase-22.4.2.300.842
4buwF33Tankyrase-22.4.2.300.809
4bus32FTankyrase-22.4.2.300.801
4l2g1V4Tankyrase-22.4.2.300.786
4l341VGTankyrase-22.4.2.300.747
4l0s1UZTankyrase-22.4.2.300.665
4iueAJ4Tankyrase-22.4.2.300.655
4kzl20DTankyrase-22.4.2.300.653
4buuF38Tankyrase-22.4.2.300.644
4l31F08Tankyrase-22.4.2.300.644
4l321VFTankyrase-22.4.2.300.644
4hlm16STankyrase-22.4.2.300.643
4l2k1V8Tankyrase-22.4.2.300.642
3p0pNNFTankyrase-22.4.2.300.641
4buiW2ETankyrase-22.4.2.300.640
4bu908CTankyrase-22.4.2.300.638
4hlh20DTankyrase-22.4.2.300.637
4j22AJ7Tankyrase-22.4.2.300.637
4l2f1V3Tankyrase-22.4.2.300.637
4hlk431Tankyrase-22.4.2.300.632
4l33F70Tankyrase-22.4.2.300.632
4hlf15ZTankyrase-22.4.2.300.630
4l0v1V1Tankyrase-22.4.2.300.629
4l10A63Tankyrase-22.4.2.300.629
4bufF36Tankyrase-22.4.2.300.624
4hkkAGITankyrase-22.4.2.300.620
4hl515WTankyrase-22.4.2.300.619
3kr8XAVTankyrase-22.4.2.300.618
5aku29FTankyrase-22.4.2.300.616
4bud29FTankyrase-22.4.2.300.610
4l0i1UWTankyrase-22.4.2.300.610
4but31FTankyrase-22.4.2.300.609
4kzuA73Tankyrase-22.4.2.300.608
4avuLDRTankyrase-22.4.2.300.606
4l091URTankyrase-22.4.2.300.606
4krs1SXTankyrase-12.4.2.300.603
4buv16ITankyrase-22.4.2.300.594
4avwG18Tankyrase-22.4.2.300.592
4hkiFLNTankyrase-22.4.2.300.591
4hknLU2Tankyrase-22.4.2.300.591
4hmhF94Tankyrase-22.4.2.300.590
4j21AJ6Tankyrase-22.4.2.300.586
4hlg20BTankyrase-22.4.2.300.568
4tkg09LTankyrase-22.4.2.300.568
4j3lAJ5Tankyrase-22.4.2.300.556
4j3mAJ8Tankyrase-22.4.2.300.551
4pnrG18Tankyrase-22.4.2.300.535
4bjbP34Tankyrase-22.4.2.300.508
4pnmNU1Tankyrase-22.4.2.300.500
4msk2C8Tankyrase-12.4.2.300.499
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.496
4dvi2IWTankyrase-12.4.2.300.489
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.488
3sqzCOAPutative hydroxymethylglutaryl-CoA synthase/0.480
3a25SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.479
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.477
4tjy3GNTankyrase-22.4.2.300.477
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.476
2ejzSAHDiphthine synthase/0.473
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.472
1lnmDTXBilin-binding protein/0.471
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.471
4twnB96Ephrin type-A receptor 32.7.10.10.470
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.466
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.465
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.465
4bjcRPBTankyrase-22.4.2.300.465
2hveADPNucleoside diphosphate kinase A2.7.4.60.464
3tqcADPPantothenate kinase/0.464
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.464
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.463
1c7oPPGHemolysin/0.462
2bfaCB3Pteridine reductase 11.5.1.330.462
3h4vDVPPteridine reductase 11.5.1.330.462
3uph0C1Genome polyprotein2.7.7.480.462
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.462
3uelA1RPoly(ADP-ribose) glycohydrolase3.2.1.1430.461
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.460
2dshSAHDiphthine synthase/0.460
3ekuCY9Actin-5C/0.460
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.460
3ihgVAKAklavinone 12-hydroxylase RdmE/0.460
2ibwCOAAcetyl-CoA acetyltransferase, mitochondrial2.3.1.90.459
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.458
4n1gCEIObelin/0.458
1swdBTNStreptavidin/0.457
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.457
3mtwM3RXaa-Pro dipeptidase, putative/0.457
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.457
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.456
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3rsv3RSBeta-secretase 13.4.23.460.456
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.456
1ut6A8NAcetylcholinesterase3.1.1.70.455
2vd0D27Hematopoietic prostaglandin D synthase/0.455
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3ozc4CTS-methyl-5'-thioadenosine phosphorylase/0.455
4mk928RGenome polyprotein2.7.7.480.455
1xk9P34Exotoxin A2.4.2.360.454
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.454
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.454
2wf4ZY4Beta-secretase 13.4.23.460.453
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.453
2eeqSAHDiphthine synthase/0.452
2j83BATUlilysin3.4.240.452
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.452
1zgbA1EAcetylcholinesterase3.1.1.70.451
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.451
2ycnP61Tyrosine phenol-lyase4.1.99.20.451
3fpkFADFerredoxin-NADP reductase/0.451
3jtaH4BNitric oxide synthase, brain1.14.13.390.451
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.451
5arkUMPRibonuclease 43.1.270.451
3zkyWT4Isopenicillin N synthase1.21.3.10.450
1r5hAO2Methionine aminopeptidase 2/0.449
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4ggzBTNBll1558 protein/0.449
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.449
2dv4SAHDiphthine synthase/0.448
2vo4GTB2,4-D inducible glutathione S-transferase/0.448
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.448
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.448
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2p6lSAHDiphthine synthase/0.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
3abxRCBGlucanase/0.447
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.447
3ix4TX1Transcriptional activator protein LasR/0.447
4i9i1DYTankyrase-12.4.2.300.447
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.447
4n3r2GUTankyrase-12.4.2.300.447
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.447
2rh1CAUBeta-2 adrenergic receptor/0.447
1odcA8BAcetylcholinesterase3.1.1.70.446
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.446
2owuSAHDiphthine synthase/0.446
2vcmM11Isopenicillin N synthase1.21.3.10.446
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.446
3jpuTY4Transcriptional activator protein LasR/0.446
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.446
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.446
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.445
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.445
2bf7HBIPteridine reductase 11.5.1.330.445
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
3hkyIX6Genome polyprotein2.7.7.480.445
3v0p4GWHisto-blood group ABO system transferase/0.445
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.445
1e92HBIPteridine reductase 11.5.1.330.444
1oc1ASVIsopenicillin N synthase1.21.3.10.444
1pd9CO4Dihydrofolate reductase1.5.1.30.444
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
1thnADPAnti-sigma F factor/0.444
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.444
2zb8IMNProstaglandin reductase 21.3.1.480.444
3a27SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase/0.444
3h59H59Genome polyprotein2.7.7.480.444
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
4n3l2FNProthrombin3.4.21.50.444
4phlPILPhosphodiesterase/0.444
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.444
1osvCHCBile acid receptor/0.443
1qorNDPQuinone oxidoreductase 1/0.443
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.443
2vcxD26Hematopoietic prostaglandin D synthase/0.443
2xi4AFTAcetylcholinesterase3.1.1.70.443
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.443
1ib1COTSerotonin N-acetyltransferase/0.442
1t57FMNConserved protein/0.442
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
1z71L17Prothrombin3.4.21.50.442
2bifANP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 42.7.1.1050.442
2e07SAHDiphthine synthase/0.442
2imkGTXAGAP009194-PA/0.442
2rgeGNPGTPase HRas/0.442
2y60M8FIsopenicillin N synthase1.21.3.10.442
3af1GDPPantothenate kinase2.7.1.330.442
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.442
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.442
4h3j10WBeta-secretase 13.4.23.460.442
1synF89Thymidylate synthase/0.441
1uh5TCLEnoyl-ACP reductase/0.441
3b6pTMPThree-prime repair exonuclease 13.1.11.20.441
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3fhxPXLPyridoxal kinase2.7.1.350.441
3nx2FERFerulic acid decarboxylase/0.441
3skgPB8Beta-secretase 13.4.23.460.441
3t64DU3Deoxyuridine 5'-triphosphate nucleotidohydrolase/0.441
3tp0FO5HTH-type transcriptional regulator EthR/0.441
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1pr6XYAPurine nucleoside phosphorylase DeoD-type/0.440
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.440
2yoj8Y6Genome polyprotein2.7.7.480.440
2zevB71Geranylgeranyl pyrophosphate synthase/0.440
3aejAA5Methionine gamma-lyase/0.440
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
3wv9FEGHmd co-occurring protein HcgE/0.440
4oztP1AEcdysone receptor, putative/0.440
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440