sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bqr | IBH | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4bqr | IBH | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 1.000 | |
| 4bqp | VMY | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.643 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.515 | |
| 4trj | 665 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.500 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.492 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.488 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.477 | |
| 3gob | HXX | DdmC | / | 0.471 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.466 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.464 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.462 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.462 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.462 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.462 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.462 | |
| 1r2j | FAD | FkbI | / | 0.461 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.460 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta | / | 0.460 | |
| 3dxj | NE6 | DNA-directed RNA polymerase subunit beta' | / | 0.460 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.455 | |
| 1ppj | ANY | Cytochrome b | / | 0.454 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 2xy9 | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.453 | |
| 4bbh | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.452 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.451 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.451 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.449 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.448 | |
| 4a1z | ADP | Kinesin-like protein KIF11 | / | 0.448 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.447 | |
| 2yne | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.447 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4up3 | NDP | Thioredoxin reductase | / | 0.447 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3qqk | X02 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.444 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3b9l | AZZ | Serum albumin | / | 0.444 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3ggg | NAD | Prephenate dehydrogenase | / | 0.444 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.443 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.443 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.442 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.442 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.441 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 3qai | XNN | Ketohexokinase | / | 0.441 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.441 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.441 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.441 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 |