sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bmz | MTA | Aminodeoxyfutalosine nucleosidase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4bmz | MTA | Aminodeoxyfutalosine nucleosidase | / | 1.000 | |
| 3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.585 | |
| 1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.575 | |
| 1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.571 | |
| 4x24 | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.530 | |
| 1y6q | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.524 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.514 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.514 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.505 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.499 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.497 | |
| 1nc1 | MTH | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.495 | |
| 1syn | F89 | Thymidylate synthase | / | 0.491 | |
| 3ftx | RE2 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.488 | |
| 2c3o | TPP | Pyruvate synthase | / | 0.487 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.486 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.486 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.485 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.485 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.485 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.484 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 4y6g | F6F | Tryptophan synthase alpha chain | / | 0.481 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.480 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.479 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.477 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.476 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.476 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.474 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.473 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.473 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.473 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.472 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.472 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.471 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.471 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.471 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.469 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.469 | |
| 1f28 | F89 | Thymidylate synthase | 2.1.1.45 | 0.468 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.468 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.468 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3dp9 | BIG | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.468 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.468 | |
| 3ua1 | 08Y | Cytochrome P450 3A4 | / | 0.468 | |
| 4eh2 | IRG | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.468 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.468 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.468 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.467 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4wkb | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.467 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3jqg | AX6 | Pteridine reductase, putative | / | 0.466 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.466 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.465 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.465 | |
| 3n87 | N87 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.465 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.465 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.464 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.464 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1thz | 326 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.463 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.463 | |
| 4eh4 | IRG | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.462 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.462 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.462 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.461 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.461 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2e1z | B4P | Propionate kinase | / | 0.460 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.460 | |
| 3k3i | I46 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.459 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.458 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.458 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4lv8 | ADP | Rhoptry protein 5 C | / | 0.458 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.458 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.457 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.457 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.457 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.457 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.457 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.456 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.456 | |
| 4m6k | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.456 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.455 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2mok | FMN | Flavodoxin 1 | / | 0.454 | |
| 3qcz | ANP | Dihydrofolate synthase/folylpolyglutamate synthase | / | 0.454 | |
| 4gd9 | BTN | Streptavidin | / | 0.454 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.454 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.454 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.453 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.453 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.453 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.453 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.453 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.453 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.452 | |
| 2c3p | 1TP | Pyruvate synthase | / | 0.452 | |
| 2j7c | IDE | Beta-glucosidase A | 3.2.1.21 | 0.452 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4oma | LCS | Methionine gamma-lyase | / | 0.452 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.452 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.451 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.451 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.451 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.450 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.450 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.450 | |
| 3epp | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.450 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.450 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.450 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.450 | |
| 4qbj | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
| 1c7o | PPG | Hemolysin | / | 0.449 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.449 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.449 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.449 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.449 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.449 | |
| 3occ | DIH | Purine nucleoside phosphorylase DeoD-type | / | 0.449 | |
| 3px3 | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.449 | |
| 3qp8 | HL0 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.449 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.449 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.448 | |
| 2pa7 | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.448 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.448 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.448 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.448 | |
| 3tn7 | NJP | Short-chain alcohol dehydrogenase | / | 0.448 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.448 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.447 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.447 | |
| 3of3 | DIH | Purine nucleoside phosphorylase DeoD-type 1 | / | 0.447 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 4b6s | 2HN | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.447 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.446 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.446 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.446 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.446 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.446 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.446 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.446 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.446 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.446 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.446 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4fj1 | GEN | 17beta-hydroxysteroid dehydrogenase | / | 0.446 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.445 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.445 | |
| 1nqx | RLP | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.445 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.445 | |
| 3c3e | FO1 | 2-phospho-L-lactate transferase | / | 0.445 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.445 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.445 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.444 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.444 | |
| 1w7k | ADP | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.444 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.444 | |
| 2o6h | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | 2.5.1.78 | 0.444 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.444 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2yhu | WHF | Pteridine reductase | / | 0.444 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.444 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.444 | |
| 3rix | 923 | Luciferin 4-monooxygenase | 1.13.12.7 | 0.444 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.444 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.444 | |
| 4lb2 | DM5 | Serum albumin | / | 0.444 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.443 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.443 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 1y5w | NEZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 1zp4 | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.443 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.443 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3lla | ACP | Myosin heavy chain kinase A | 2.7.11.7 | 0.443 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.443 | |
| 3zm5 | IGM | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 4fr1 | 0V2 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.443 | |
| 4zth | GG5 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.442 | |
| 1z5u | CMP | Class B acid phosphatase | / | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.442 | |
| 3bgv | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.442 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4blw | SAH | Ribosomal RNA large subunit methyltransferase J | / | 0.442 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.442 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.441 | |
| 1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.441 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.441 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4eh3 | IRG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4eh5 | IRG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4gg9 | 0WW | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4kxj | P34 | Nucleoprotein | / | 0.441 | |
| 4nbl | 2J6 | Caspase-6 | 3.4.22.59 | 0.441 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1m67 | BOA | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.440 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.440 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.440 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.440 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.440 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3ix8 | TX3 | Transcriptional activator protein LasR | / | 0.440 | |
| 3pfh | T3Q | dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase | 2.1.1.235 | 0.440 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.440 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.440 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.440 | |
| 4hkk | AGI | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 |