sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 1.000 | |
| 4fv3 | EK6 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.524 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.521 | |
| 2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.507 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.504 | |
| 2bro | DF2 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.501 | |
| 4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.501 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.496 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.496 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.496 | |
| 4bfm | ANP | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.495 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.494 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.494 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.493 | |
| 2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.492 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.492 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.491 | |
| 3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.491 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.490 | |
| 3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.489 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.486 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.486 | |
| 4c3f | 7KW | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.486 | |
| 3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.485 | |
| 2wtc | VGM | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.484 | |
| 4ux9 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.484 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.483 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.483 | |
| 4fv5 | EK9 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.483 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.483 | |
| 2xj2 | 985 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.482 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.482 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.481 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.481 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.479 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.479 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.478 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.478 | |
| 2j0m | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.477 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.477 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.477 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.477 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.476 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.475 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.475 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.474 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.474 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.474 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.474 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.473 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.473 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.472 | |
| 4kio | G5K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.472 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.471 | |
| 5a3c | NAD | SIR2 family protein | / | 0.471 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.470 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.470 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.470 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.469 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 2b9i | ADP | Mitogen-activated protein kinase FUS3 | 2.7.11.24 | 0.468 | |
| 2wtd | ZZK | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.468 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.468 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.467 | |
| 4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.467 | |
| 4fv2 | EK5 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.467 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.467 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.466 | |
| 3f69 | XDR | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.466 | |
| 3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.466 | |
| 4c4i | X20 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.466 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3ic9 | FAD | Putative dihydrolipoamide dehydrogenase | / | 0.465 | |
| 4bgg | 844 | Activin receptor type-1 | 2.7.11.30 | 0.465 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 3hrf | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
| 3umo | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.464 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.464 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 4zs2 | FLU | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.464 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
| 3r2b | 05B | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.463 | |
| 4c57 | FEF | Cyclin-G-associated kinase | 2.7.11.1 | 0.463 | |
| 4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.463 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2hck | QUE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.462 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 4enx | Z20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.462 | |
| 4fv1 | EK4 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.462 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 2y4g | TIR | TamL | / | 0.461 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.461 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.461 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.461 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4o0w | ADN | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.461 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.460 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.460 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 3hrc | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.460 | |
| 3nie | ANP | Mitogen-activated protein kinase | / | 0.460 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.460 | |
| 5ap7 | SVE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.460 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.459 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.459 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.459 | |
| 4hjf | C2E | GGDEF family protein | / | 0.459 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.459 | |
| 1h0w | 207 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.458 | |
| 3c4x | ATP | Rhodopsin kinase | / | 0.458 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.458 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.458 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.457 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.457 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.457 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.457 | |
| 4c4g | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.457 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.457 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.457 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.457 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.457 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.457 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.456 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.456 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.456 | |
| 3gu7 | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.456 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.456 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 4c4f | 7CE | Dual specificity protein kinase TTK | 2.7.12.1 | 0.456 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.456 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.456 | |
| 4wsq | KSA | AP2-associated protein kinase 1 | 2.7.11.1 | 0.456 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1uu7 | BI2 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.455 | |
| 2buj | STU | Serine/threonine-protein kinase 16 | / | 0.455 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2g5c | NAD | Prephenate dehydrogenase | / | 0.455 | |
| 2j9m | PY8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.455 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.455 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.455 | |
| 4h3q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.455 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.455 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2xrw | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.454 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.454 | |
| 3qxp | X64 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.454 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.454 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.453 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.453 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
| 2e9v | 85A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.453 | |
| 4fx3 | 60K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.453 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.452 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.452 | |
| 3kvx | FMY | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.452 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.452 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4rqk | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.452 | |
| 2jkk | BI9 | Focal adhesion kinase 1 | 2.7.10.2 | 0.451 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.451 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.451 | |
| 4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.451 | |
| 4g2f | C07 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4ivb | 1J5 | Tyrosine-protein kinase JAK1 | / | 0.451 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.450 | |
| 1unl | RRC | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.450 | |
| 2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.450 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.450 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.450 | |
| 3gub | GUB | Death-associated protein kinase 1 | 2.7.11.1 | 0.450 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.450 | |
| 3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.450 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.450 | |
| 4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 1v0p | PVB | Cell division control protein 2 homolog | 2.7.11.22 | 0.449 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2c4g | 514 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.449 | |
| 2y3r | TIR | TamL | / | 0.449 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1h1r | 6CP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2cke | IQU | Death-associated protein kinase 2 | / | 0.448 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.448 | |
| 3r7y | Z04 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 4ez5 | 0RS | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.448 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.448 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1wlv | COA | Phenylacetic acid degradation protein PaaI | / | 0.447 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.447 | |
| 2xs0 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.447 | |
| 3lit | E15 | Protease | / | 0.447 | |
| 3my5 | RFZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3qql | X03 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4c4h | 7RO | Dual specificity protein kinase TTK | 2.7.12.1 | 0.447 | |
| 4fv4 | EK7 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4kz0 | 1UJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.446 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.446 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.446 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.446 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.446 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.446 | |
| 3qru | X19 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.446 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.446 | |
| 4w9w | YDJ | BMP-2-inducible protein kinase | 2.7.11.1 | 0.446 | |
| 5a3b | APR | SIR2 family protein | / | 0.446 | |
| 1c70 | L75 | Protease | / | 0.445 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.445 | |
| 2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
| 2qoq | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.445 | |
| 2w0j | ZAT | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.445 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 3i2l | 2NC | Protease | / | 0.445 | |
| 3qcs | 3Q1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.445 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.444 | |
| 1tvo | FRZ | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2cgv | 3B3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 2qo7 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.444 | |
| 3r9d | X6B | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3rkb | 12Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.444 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.444 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.444 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.444 | |
| 3zm4 | 22T | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.444 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 4ft0 | HK9 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4g1w | G1W | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.444 | |
| 4i22 | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 5cvf | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.444 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.443 | |
| 2uzb | C75 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2y3s | TIR | TamL | / | 0.443 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3she | I85 | MAP kinase-activated protein kinase 3 | 2.7.11.1 | 0.443 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.443 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.443 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.443 | |
| 5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.443 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.442 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.442 | |
| 2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.442 | |
| 3ezv | EZV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.442 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.442 | |
| 4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.442 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.442 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.442 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.441 | |
| 2ydj | YDJ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.441 | |
| 3rak | 03Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.441 | |
| 1ha3 | MAU | Elongation factor Tu-A | / | 0.440 | |
| 2c6d | ANP | Aurora kinase A | 2.7.11.1 | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 2wpa | 889 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2zdu | 446 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.440 | |
| 4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.440 | |
| 4jik | 1KO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.440 | |
| 4yuq | KS1 | Calmodulin-like domain protein kinase | / | 0.440 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 | |
| 5c41 | ACP | Ribokinase | / | 0.440 |