sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 1.000 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.612 | |
| 3u9y | 09L | Tankyrase-2 | 2.4.2.30 | 0.606 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.593 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.570 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.567 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.565 | |
| 3c4h | DRL | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.561 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.558 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.554 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.547 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.547 | |
| 1xk9 | P34 | Exotoxin A | 2.4.2.36 | 0.545 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.542 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.537 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.535 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.535 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.534 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.533 | |
| 3q9o | NAD | Cholix toxin | 2.4.2.36 | 0.530 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.528 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.528 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.528 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.527 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.527 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.525 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.523 | |
| 1zm4 | TAD | Exotoxin A | 2.4.2.36 | 0.522 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.522 | |
| 4hl5 | 15W | Tankyrase-2 | 2.4.2.30 | 0.521 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.518 | |
| 2zit | NAD | Exotoxin A | 2.4.2.36 | 0.516 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.513 | |
| 1uk1 | FRQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.510 | |
| 3b8h | NAD | Exotoxin A | 2.4.2.36 | 0.509 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.505 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.504 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.504 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.500 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.500 | |
| 3b78 | NAD | Exotoxin A | 2.4.2.36 | 0.499 | |
| 4iue | AJ4 | Tankyrase-2 | 2.4.2.30 | 0.489 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.489 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.482 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 4l0i | 1UW | Tankyrase-2 | 2.4.2.30 | 0.481 | |
| 2x9g | LYA | Pteridine reductase | / | 0.480 | |
| 4buw | F33 | Tankyrase-2 | 2.4.2.30 | 0.479 | |
| 4l32 | 1VF | Tankyrase-2 | 2.4.2.30 | 0.478 | |
| 4l33 | F70 | Tankyrase-2 | 2.4.2.30 | 0.478 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.477 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 4j22 | AJ7 | Tankyrase-2 | 2.4.2.30 | 0.476 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.473 | |
| 4l0t | 1V0 | Tankyrase-2 | 2.4.2.30 | 0.473 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.472 | |
| 4l34 | 1VG | Tankyrase-2 | 2.4.2.30 | 0.472 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.470 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.469 | |
| 4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.469 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.468 | |
| 4buf | F36 | Tankyrase-2 | 2.4.2.30 | 0.468 | |
| 4bux | F35 | Tankyrase-2 | 2.4.2.30 | 0.466 | |
| 4hmh | F94 | Tankyrase-2 | 2.4.2.30 | 0.465 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.464 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.461 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.461 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.461 | |
| 1fml | RTL | Retinol dehydratase | / | 0.460 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.460 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.458 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.458 | |
| 4avw | G18 | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4hlh | 20D | Tankyrase-2 | 2.4.2.30 | 0.457 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4j21 | AJ6 | Tankyrase-2 | 2.4.2.30 | 0.456 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 4bud | 29F | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4kzl | 20D | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.454 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.452 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.450 | |
| 4k37 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.450 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.450 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.449 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.449 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.449 | |
| 2yhu | WHF | Pteridine reductase | / | 0.448 | |
| 3p0p | NNF | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.447 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 3w0t | HPU | Lactoylglutathione lyase | 4.4.1.5 | 0.447 | |
| 4e2y | JHZ | Methyltransferase | / | 0.447 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 4kzu | A73 | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.445 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2vz0 | D64 | Pteridine reductase | / | 0.445 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.445 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1s36 | CEI | Obelin | / | 0.443 | |
| 2gl0 | ADN | Uncharacterized protein | / | 0.443 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.442 | |
| 2vet | UMP | Thymidylate synthase | / | 0.442 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.442 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.441 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.441 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.441 | |
| 4l1x | STR | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.440 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.440 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.440 | |
| 4l0v | 1V1 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4l10 | A63 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 |