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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4biwANPSensor histidine kinase CpxA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4biwANPSensor histidine kinase CpxA/1.000
1i59ANPChemotaxis protein CheA2.7.13.30.557
3dgeADPSensor histidine kinase/0.530
1tilATPAnti-sigma F factor/0.524
3sl2ATPSensor histidine kinase WalK/0.519
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.499
1i5cADPChemotaxis protein CheA2.7.13.30.493
2c2aADPSensor histidine kinase/0.492
4bizADPSensor histidine kinase CpxA/0.491
1i5bANPChemotaxis protein CheA2.7.13.30.485
1nhhANPDNA mismatch repair protein MutL/0.485
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.480
1thnADPAnti-sigma F factor/0.478
1l0oADPAnti-sigma F factor/0.474
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.473
1xddAAYIntegrin alpha-L/0.470
5c93ACPTwo-component system histidine protein kinase/0.467
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.466
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.465
1qiqACCIsopenicillin N synthase1.21.3.10.464
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.464
4q71FADBifunctional protein PutA/0.464
2zdyADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.462
2npiATPmRNA cleavage and polyadenylation factor CLP1/0.461
2zkjADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.461
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.459
2a9y26AAdenosine kinase2.7.1.200.458
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
2bf4FMNNADPH--cytochrome P450 reductase/0.457
1i5aACPChemotaxis protein CheA2.7.13.30.456
1id0ANPSensor protein PhoQ2.7.13.30.455
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.455
4c0bATPmRNA cleavage and polyadenylation factor CLP1/0.454
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.454
4iarERM5-hydroxytryptamine receptor 1B/0.454
1opmIYGPeptidyl-glycine alpha-amidating monooxygenase1.14.17.30.453
3ekuCY9Actin-5C/0.453
3gw9VNILanosterol 14-alpha-demethylase/0.453
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
2g8yNADHydroxycarboxylate dehydrogenase B/0.452
4bixADPSensor histidine kinase CpxA/0.452
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.449
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.448
3gy0NAPNAD(P)-dependent oxidoreductase/0.448
3u9eCOALmo1369 protein/0.448
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4opiFDAConserved Archaeal protein/0.448
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2rqfJH3Hemolymph juvenile hormone binding protein/0.447
3a0tADPSensor histidine kinase/0.447
1b2lNDCAlcohol dehydrogenase1.1.1.10.446
3fr5I4AFatty acid-binding protein, adipocyte/0.446
2e0aANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.445
3w8rACPUridine kinase/0.445
1dliUDXUDP-glucose 6-dehydrogenase/0.444
1gky5GPGuanylate kinase2.7.4.80.444
1oc1ASVIsopenicillin N synthase1.21.3.10.444
1synF89Thymidylate synthase/0.444
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.444
2po7CHDFerrochelatase, mitochondrial4.99.1.10.444
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.444
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.443
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.443
4jauADPSensor histidine kinase/0.443
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.442
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.442
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.442
4uymVOR14-alpha sterol demethylase Cyp51B/0.442
1hfqMOTDihydrofolate reductase1.5.1.30.441
1i59ADPChemotaxis protein CheA2.7.13.30.441
3d3wNAPL-xylulose reductase1.1.1.100.441
3h3r14HCollagen type IV alpha-3-binding protein/0.441
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3otwCOAPhosphopantetheine adenylyltransferase/0.441
3tr05GPGuanylate kinase/0.441
4ips1G4Mycocyclosin synthase1.14.21.90.441
4nieNBHNuclear receptor ROR-gamma/0.441
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.441
1vbiNADMalate/L-lactate dehydrogenase family protein/0.440
2qc8ADPGlutamine synthetase6.3.1.20.440
3qlsNDPDihydrofolate reductase1.5.1.30.440
3slkNDPPolyketide synthase extender module 2/0.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440