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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.251.000
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.577
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.522
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.512
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.502
1pmn984Mitogen-activated protein kinase 102.7.11.240.496
3gxlQIGTGF-beta receptor type-12.7.11.300.496
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.495
3l8p0CEAngiopoietin-1 receptor2.7.10.10.495
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.495
5e8wSTUTGF-beta receptor type-12.7.11.300.494
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.492
4nk92K5Fibroblast growth factor receptor 1/0.492
2pvhP19Casein kinase II subunit alpha2.7.11.10.491
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.489
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.489
5e8xSTUTGF-beta receptor type-12.7.11.300.488
1eh4IC1Casein kinase I homolog 12.7.11.10.485
4yuqKS1Calmodulin-like domain protein kinase/0.485
5dr9SKEAurora kinase A2.7.11.10.485
4f650S9Fibroblast growth factor receptor 1/0.484
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.483
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.482
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.482
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.482
3uyt0CKCasein kinase I isoform delta2.7.11.10.481
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.481
4hnf16WCasein kinase I isoform delta2.7.11.10.481
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.480
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.479
1bygSTUTyrosine-protein kinase CSK/0.478
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.477
4e4m0NHTyrosine-protein kinase JAK2/0.477
4y93746Tyrosine-protein kinase/0.476
2h96893Mitogen-activated protein kinase 82.7.11.240.475
4o0wADNAurora kinase A2.7.11.10.474
4i22IREEpidermal growth factor receptor2.7.10.10.473
4j95ACPFibroblast growth factor receptor 2/0.473
4k33ACPFibroblast growth factor receptor 32.7.10.10.473
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.473
1aq1STUCyclin-dependent kinase 22.7.11.220.472
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.472
3gubGUBDeath-associated protein kinase 12.7.11.10.472
4hvg19QTyrosine-protein kinase JAK32.7.10.20.472
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.472
4nka2K7Fibroblast growth factor receptor 1/0.472
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.471
2dwbANPAurora kinase A2.7.11.10.470
4jia1K3Tyrosine-protein kinase JAK2/0.470
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.469
2itzIREEpidermal growth factor receptor2.7.10.10.469
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.469
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.468
3hmm855TGF-beta receptor type-12.7.11.300.468
4anmWULCasein kinase II subunit alpha2.7.11.10.468
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.467
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
4j97ACPFibroblast growth factor receptor 2/0.467
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.465
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.465
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
4aotGW8Serine/threonine-protein kinase 102.7.11.10.464
4gub0Y4Casein kinase II subunit alpha2.7.11.10.464
2pwlACPFibroblast growth factor receptor 2/0.463
2x1nX1NCyclin-dependent kinase 22.7.11.220.463
3ttjJBIMitogen-activated protein kinase 102.7.11.240.463
4jq8KJ8Epidermal growth factor receptor2.7.10.10.463
5dr6SKEAurora kinase A2.7.11.10.463
1bxoPP7Penicillopepsin-13.4.23.200.462
1dawANPCasein kinase II subunit alpha2.7.11.10.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.462
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.461
3w33W19Epidermal growth factor receptor2.7.10.10.461
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.461
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.460
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.460
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.460
1h1s4SPCyclin-dependent kinase 22.7.11.220.459
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2fgiPD1Fibroblast growth factor receptor 1/0.459
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.459
3zewSTUEphrin type-B receptor 42.7.10.10.459
4hvh19RTyrosine-protein kinase JAK32.7.10.20.459
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.459
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
5e8ySTUTGF-beta receptor type-22.7.11.300.459
1e9hINRCyclin-dependent kinase 22.7.11.220.458
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.457
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.457
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
4hvi19STyrosine-protein kinase JAK32.7.10.20.457
5drdATPAurora kinase A2.7.11.10.457
1u4dDBQActivated CDC42 kinase 1/0.456
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.456
2itqITQEpidermal growth factor receptor2.7.10.10.456
2yn8STUEphrin type-B receptor 42.7.10.10.456
4jqeANPCasein kinase II subunit alpha2.7.11.10.456
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.455
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.454
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.454
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.454
1g5sI17Cyclin-dependent kinase 22.7.11.220.453
1hiiC20Gag-Pol polyprotein/0.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.453
5dpvSKEAurora kinase A2.7.11.10.453
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.452
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.452
3lfnA27Cyclin-dependent kinase 22.7.11.220.452
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
5dt3ATPAurora kinase A2.7.11.10.452
1ol7ADPAurora kinase A2.7.11.10.451
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.451
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.451
2iw84SPCyclin-dependent kinase 22.7.11.220.451
2v7a627Tyrosine-protein kinase ABL12.7.10.20.451
4btkDTQTau-tubulin kinase 12.7.11.10.451
4dgmAGICasein kinase II subunit alpha2.7.11.10.451
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.451
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.450
2py3ACPFibroblast growth factor receptor 2/0.450
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.450
4jajXU1Aurora kinase A2.7.11.10.450
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.450
2ckeIQUDeath-associated protein kinase 2/0.449
2itpAEEEpidermal growth factor receptor2.7.10.10.449
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.449
3mtfA3FActivin receptor type-12.7.11.300.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.449
1idb0DOGag-Pol polyprotein/0.448
1ke6LS2Cyclin-dependent kinase 22.7.11.220.448
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.448
2wecPP5Penicillopepsin-13.4.23.200.448
3w2sW2REpidermal growth factor receptor2.7.10.10.448
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
5dnrATPAurora kinase A2.7.11.10.448
1bxqPP8Penicillopepsin-13.4.23.200.447
2hk51BMTyrosine-protein kinase HCK2.7.10.20.447
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.447
2wotZZGTGF-beta receptor type-12.7.11.300.447
2xneASHAurora kinase A2.7.11.10.447
3gu83GUDeath-associated protein kinase 12.7.11.10.447
3mvl38PMitogen-activated protein kinase 14/0.447
3oroAGSSerine/threonine protein kinase/0.447
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.447
3tqhNDPQuinone oxidoreductase/0.447
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.447
3w2rW2REpidermal growth factor receptor2.7.10.10.447
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.447
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.447
1k6tXN1Gag-Pol polyprotein3.4.23.160.446
1vjy460TGF-beta receptor type-12.7.11.300.446
2in6839Wee1-like protein kinase2.7.10.20.446
2of2547Tyrosine-protein kinase Lck2.7.10.20.446
3och2MXDihydrofolate reductase1.5.1.30.446
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
4j99ACPFibroblast growth factor receptor 2/0.446
4kba1QMCasein kinase I isoform delta2.7.11.10.446
4nks2M2Fibroblast growth factor receptor 1/0.446
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3dogNNNCyclin-dependent kinase 22.7.11.220.445
3le62BZCyclin-dependent kinase 22.7.11.220.445
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.445
4f640S8Fibroblast growth factor receptor 1/0.445
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.445
2pvlP55Casein kinase II subunit alpha2.7.11.10.444
3i60E86Mitogen-activated protein kinase 12.7.11.240.444
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.444
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.444
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.444
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
1di8DTQCyclin-dependent kinase 22.7.11.220.443
1ke7LS3Cyclin-dependent kinase 22.7.11.220.443
1ppm0P1Penicillopepsin-13.4.23.200.443
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.443
2excJNKMitogen-activated protein kinase 102.7.11.240.443
2uzeC95Cyclin-dependent kinase 22.7.11.220.443
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.443
3f46I2C5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.443
3u9eCOALmo1369 protein/0.443
3vs1VSATyrosine-protein kinase HCK2.7.10.20.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4ewhT77Activated CDC42 kinase 1/0.443
1lp4ANPCasein kinase II subunit alpha2.7.11.10.442
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
2np8CC3Aurora kinase A2.7.11.10.442
2pmoHMDProtein kinase 7/0.442
2w05FRTCyclin-dependent kinase 22.7.11.220.442
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.442
2xa4AZ5Tyrosine-protein kinase JAK2/0.442
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.441
2uzlC94Cyclin-dependent kinase 22.7.11.220.441
3icrCOACoenzyme A disulfide reductase/0.441
3lfqA28Cyclin-dependent kinase 22.7.11.220.441
4erwSTUCyclin-dependent kinase 22.7.11.220.441
4o0sADNAurora kinase A2.7.11.10.441
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.441
5dn3ATPAurora kinase A2.7.11.10.441
1m2qMNXCasein kinase II subunit alpha2.7.11.10.440
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.440
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440